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PICROTIN

Product Name
PICROTIN
CAS No.
21416-53-5
Chemical Name
PICROTIN
Synonyms
PICROTIN;Picrotin CRS;(1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-Hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione;3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-;(1aR,8aS,9S)-1aβ,2,2a,6,6aα,8b-Hexahydro-2aα-hydroxy-9-(1-hydroxy-1-methylethyl)-8bα-methyl-3α,6α-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione
CBNumber
CB2383778
Molecular Formula
C15H18O7
Formula Weight
310.3
MOL File
21416-53-5.mol
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PICROTIN Property

Melting point:
256-258°C
alpha 
D -64.7° (c = 2.31 in abs alc)
Boiling point:
595.8±50.0 °C(Predicted)
Density 
1.59
storage temp. 
2-8°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml
pka
13.28±0.60(Predicted)
EPA Substance Registry System
Picrotin (21416-53-5)
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Safety

WGK Germany 
3
RTECS 
TJ8800000
Toxicity
LD50 i.p. in mice: 135 mg/kg (Jarboe)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001508
Product name
Picrotin
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001508
Price
$220
Updated
2024/03/01
Cayman Chemical
Product number
21870
Product name
Picrotin
Purity
≥98%
Packaging
25mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21870
Product name
Picrotin
Purity
≥98%
Packaging
50mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
21870
Product name
Picrotin
Purity
≥98%
Packaging
100mg
Price
$98
Updated
2024/03/01
Cayman Chemical
Product number
21870
Product name
Picrotin
Purity
≥98%
Packaging
250mg
Price
$169
Updated
2024/03/01
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PICROTIN Chemical Properties,Usage,Production

Description

Picrotin is a natural picrotoxane that antagonizes glycine receptors (GlyRs; IC50s = 57 and 117 μM for α1 and α2 homodimeric GlyRs, respectively). It also inhibits α3 homodimeric GlyRs. Picrotin is inactive in inhibiting γ-aminobutyric acid (GABA) type A and type C receptors. Picrotin occurs in the natural plant-derived poison picrotoxin , equimolar with picrotoxinin.

Uses

GABAa receptor antagonist

Definition

ChEBI: Picrotin is an organic heteropentacyclic compound that is picrotoxinin in which the olefinic double bond has undergone addition of water to give the corresponding tertiary alcohol. It is the less toxic component of picrotoxin, lacking GABA activity. It has a role as a plant metabolite. It is an organic heteropentacyclic compound, an epoxide, a tertiary alcohol, a gamma-lactone, a diol and a picrotoxane sesquiterpenoid. It is functionally related to a picrotoxinin.

PICROTIN Preparation Products And Raw materials

Raw materials

Preparation Products

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PICROTIN Suppliers

China 45 France 1 Germany 2 India 1 South Korea 1 Switzerland 1 United Kingdom 7 United States 11 Global 69
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
Country
China
ProdList
925
Advantage
58
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8073
Advantage
58
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7892
Advantage
56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15185
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
7059
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8449
Advantage
60
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27322
Advantage
60

21416-53-5, PICROTINRelated Search:

PICROTIN (R)-5-Hydroxymethyldihydrofuran-2-one ETHYL N-HEPTYLOXYACETATE 3-HEPTYLDIHYDRO-5-METHYL-2(3H)-FURANONE ETHYL TETRAHYDROPYRAN-4-YL-ACETATE cis-4-Hydroxycyclohexanecarboxylic acid Tetrahydropyranyl-4-acetic acid ε-Caprolactone D-(-)-PANTOLACTONE 4-METHOXYCYCLOHEXANECARBOXYLIC ACID TETRAHYDROFURFURYL BUTYRATE Undecanedioic acid DL-Pantolactone Molecular complex (1:1) of picrotin and picrotoxinin,picrotin,compd.withpicrotoxinin(1:1 TRANS-P-MENTHANE-3,8-DIOL METHYL 2-METHYLGLYCIDATE 2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID METHYL ESTER 6-OXABICYCLO[3.2.1]OCTAN-7-ONE

  • PICROTIN
  • (1aR,8aS,9S)-1aβ,2,2a,6,6aα,8b-Hexahydro-2aα-hydroxy-9-(1-hydroxy-1-methylethyl)-8bα-methyl-3α,6α-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione
  • (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-Hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione
  • Picrotin CRS
  • 3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-
  • 21416-53-5
  • C15H18O7
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