Tetrahydropyranyl-4-acetic acid

Product Name: Tetrahydropyranyl-4-acetic acid
CAS No.: 85064-61-5
Chemical Name: Tetrahydropyranyl-4-acetic acid
Synonyms: 2-(oxan-4-yl)acetic acid;Tetrahydropyranyl-4-aceti...;Tetrahydro-4-pyranacetic acid;Tetrahydropyran-4-acetic acid;TETRAHYDROPYRANYL-4-ACETIC ACID;Tetrahydro-2H-pyran-4-acetic acid;2-Tetrahydropyran-4-ylacetic acid;Tetrahydropyran-4-acetic acid ,97%;2-(4-Tetrahydropyranyl)acetic Acid;TETRAHYDRO-2H-PYRAN-4-YLACETIC ACID
CBNumber: CB1340192
Molecular Formula: C7H12O3
Formula Weight: 144.17
MOL File: 85064-61-5.mol

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Tetrahydropyranyl-4-acetic acid Property

Melting point:: 48-50°C
Boiling point:: 285.1±13.0 °C(Predicted)
Density: 1.111±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 4.60±0.10(Predicted)
color: White
CAS DataBase Reference: 85064-61-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-41-37/38
Safety Statements: 26-36/37/39-22-39
RIDADR: 1759
Hazard Note: Irritant/Keep Cold
HazardClass: 8
PackingGroup: Ⅲ
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: T795433
Product name: Tetrahydropyranyl-4-aceticAcid
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Oakwood

Product number: 011896
Product name: Tetrahydropyranyl-4-aceticacid
Packaging: 1g
Price: $19
Updated: 2021/12/16

Matrix Scientific

Product number: 068502
Product name: 2-Tetrahydropyran-4-ylacetic acid
Purity: >95%
Packaging: 1g
Price: $20
Updated: 2021/12/16

Apolloscientific

Product number: OR10586
Product name: Tetrahydro-2H-pyran-4-ylaceticacid
Purity: 97%
Packaging: 1g
Price: $28
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H21-1-Z2
Product name: Tetrahydro-2H-pyran-4-ylaceticacid
Purity: 97.0%
Packaging: 1g
Price: $31
Updated: 2021/12/16

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Tetrahydropyranyl-4-acetic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

Tetrahydropyranyl-4-acetic acid is mainly used as a protecting agent in organic synthesis, especially in the multi-step complex synthesis of organic molecules to protect functional groups such as hydroxyl or amino groups.

Synthesis

103260-44-2

85064-61-5

General procedure for the synthesis of tetrahydropyran-4-acetic acid from ethyl tetrahydropyran-4-yl-acetate: 1. a solution of sodium hydroxide (15.9 g, 44.06 mmol) in water (150 ml) was added dropwise to a methanolic solution of ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate (15 g, 8.81 mmol) at 0 °C or lower. 2. The mixture was stirred at room temperature for 15 hours. 3. The solvent was removed from the reaction mixture by depressurized distillation. 4. The aqueous layer was adjusted to pH 3 by adding 1 M hydrochloric acid and extracted with ethyl acetate. 5. Wash the organic layer with saturated brine and dry with anhydrous sodium sulfate. 6. The filtrate was concentrated under pressure to give tetrahydropyran-4-acetic acid as a colorless solid (12.0 g, 94%). This compound can be used in the next step without further purification. 7. Benzyl bromide (14.3 g, 83.33 mmol) was added dropwise to a suspension of tetrahydropyran-4-acetic acid (10.0 g, 69.44 mmol) and anhydrous potassium carbonate (28.8 g, 208.3 mmol) in acetonitrile (100 ml) at room temperature. 8. The mixture was refluxed for 48 hours. 9. The solvent was removed from the mixture by decompression distillation and the residue was diluted with water and extracted with dichloromethane. 10. The organic layer was dried over anhydrous sodium sulfate. 11. The filtrate was concentrated under pressure and the residue was chromatographed on a silica gel column (hexane: ethyl acetate = 9:1) to afford benzyl tetrahydropyran-4-acetate as an oil (12.0 g, 75% yield). 12. 12. Product characterization data: 1H-NMR (400 MHz, CDCl3): δ (ppm) 7.39-7.34 (m, 5H), 5.12 (s, 2H), 3.95-3.92 (m, 2H), 3.42-3.36 (m, 2H), 2.30 (d, J = 7.2 Hz, 2H), 2.09-1.99 (m, 1H) 1.64-1.61 (m, 2H), 1.39-1.29 (m, 2H); MS (ESI): m/z 234 (M+).

References

[1] Patent: EP2737900, 2014, A1. Location in patent: Paragraph 0114; 0117-0118
[2] Journal of Medicinal Chemistry, 1993, vol. 36, # 16, p. 2300 - 2310
[3] Patent: US5221671, 1993, A
[4] Patent: EP1019398, 2004, B1. Location in patent: Page 51

Tetrahydropyranyl-4-acetic acid Preparation Products And Raw materials

Raw materials

Tetrahydro-2H-pyran-4-carboxylic acid Sodium cyanide Tetrahydrofuran Lithium Aluminum Hydride Phosphorus tribromide

Preparation Products

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Tetrahydropyranyl-4-acetic acid Suppliers

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View Lastest Price from Tetrahydropyranyl-4-acetic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Tetrahydropyranyl-4-aceticacid 85064-61-5
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-27

Shaanxi Dideu New Materials Co. Ltd

Product: Tetrahydropyranyl-4-acetic acid 85064-61-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-01

Dideu Industries Group Limited

Product: Tetrahydropyranyl-4-acetic acid 85064-61-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-29

85064-61-5, Tetrahydropyranyl-4-acetic acidRelated Search:

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Tetrahydropyran-4-yl-acetic acid, 97%

85064-61-5

85064-81-5

Carboxylic acid

Carboxylic Acids

Pyrans, Piperidines & Piperazines

Heterocycles series

Carboxylic Acids

Pyrans, Piperidines &Piperazines

blocks

Carboxes

Heterocycles