(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL

Product Name: (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL
CAS No.: 14774-37-9
Chemical Name: (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL
Synonyms: TETRAHYDROPYRAN-4-METHANOL;oxan-4-ylMethanol;15N]-Ammonium Chloride;Tetrahydropyran-4-Methano;TERTAHYDROPYRAN-4-METHANOL;4-(Hydroxymethyl)tetrahyd...;4-(Hydroxymethyl)tetrahydropyr;Tetrahydropyran-4-methanol?New;4-(Hydroxymethyl)tetrahydropyran;(TETRAHYDRO-PYRAN-4-YL)-METHANOL
CBNumber: CB5780709
Molecular Formula: C6H12O2
Formula Weight: 116.16
MOL File: 14774-37-9.mol

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(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL Property

Boiling point:: 105 °C
Density: 1.000±0.06 g/cm3(Predicted)
Flash point:: 61°(142°F)
refractive index: 1.4600
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
pka: 14.85±0.10(Predicted)
color: Colorless to Light yellow to Light orange
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C6H12O2/c7-5-6-1-3-8-4-2-6/h6-7H,1-5H2
InChIKey: YSNVSVCWTBLLRW-UHFFFAOYSA-N
SMILES: C1OCCC(CO)C1
CAS DataBase Reference: 14774-37-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22-41-37/38
Safety Statements: 26-36/37/39-23-39
HazardClass: IRRITANT
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T2965
Product name: Tetrahydropyran-4-methanol
Purity: >97.0%(GC)
Packaging: 1g
Price: $126
Updated: 2025/07/31

TCI Chemical

Product number: T2965
Product name: Tetrahydropyran-4-methanol
Purity: min. 97.0 %
Packaging: 5G
Price: $378
Updated: 2025/07/31

TRC

Product number: H947675
Product name: 4-(Hydroxymethyl)tetrahydropyran
Packaging: 10g
Price: $385
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0032347
Product name: (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL
Purity: 95.00%
Packaging: 1G
Price: $628.44
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0032347
Product name: (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL
Purity: 95.00%
Packaging: 5G
Price: $948.68
Updated: 2021/12/16

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(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

Used as a reagent in the identification and optimization of pteridinone Toll-like receptor 7 agonists, which can be used for the oral treatment of viral hepatitis. 4-(Hydroxymethyl)tetrahydropyran is also a starting material for [1-[(Tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone which is a drug that acts as CB2 cannabinoid receptor agonist.

Synthesis

96835-17-5

14774-37-9

Ethyl tetrahydro-2H-pyran-4-carboxylate (5.0 g, 34.7 mmol) was slowly added to a stirred suspension of lithium aluminum hydride (LiAlH4, 4.0 g, 104 mmol) in tetrahydrofuran (THF, 100 mL) at 0 °C. The reaction mixture was kept stirred at 0 °C for 1 hour. Subsequently, ethyl acetate (20 mL) was added slowly and dropwise to the reaction mixture to quench the excess LiAlH4, followed by the addition of 10% aqueous sodium hydroxide (NaOH). The resulting mixture was continued to be stirred for 30 minutes. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad to remove insoluble impurities. The filtrate was concentrated under reduced pressure to give the target product (tetrahydro-2H-pyran-4-yl) methanol (9) as a colorless oil. The yield was 3.9 g in 96% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d5): δ 4.46 (broad single peak, 1H), 3.82 (double peak, J=8.0 Hz, 2H), 3.25-3.22 (multiple peaks, 4H), 1.62-1.52 (multiple peaks, 3H), 1.18-1.04 (multiple peaks, 1H).

References

[1] Patent: US2014/275043, 2014, A1. Location in patent: Paragraph 0415; 0416
[2] Justus Liebigs Annalen der Chemie, 1936, vol. 525, p. 292,294
[3] Patent: WO2010/96371, 2010, A2. Location in patent: Page/Page column 156

(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL Preparation Products And Raw materials

Raw materials

Ethanol Potassium hydroxide Acetone Sodium Tetrahydro-2H-pyran-4-carboxylic acid 2,2'-Dichlorodiethyl ether Tetrahydrofuran Lithium Aluminum Hydride Diethyl malonate

Preparation Products

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(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL Suppliers

Austria 1 Belgium 1 China 245 Germany 3 India 10 Japan 1 United Kingdom 3 United States 19 Global 283

ITIC MEDCHEM(SUZHOU) CO.,LTD.

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Energy Chemical

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View Lastest Price from (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Tetrahydropyran-4-methanol 14774-37-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Henan Fengda Chemical Co., Ltd

Product: (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL 14774-37-9
Price: US $31.00-1.50/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-10

PNP Biotech Co. Ltd

Product: Tetrahydropyran-4-methanol 14774-37-9
Price: US $0.00/KG
Min. Order: 25KG
Purity: ≥95%
Supply Ability: Inquiry
Release date: 2022-09-20

14774-37-9, (TETRAHYDRO-2H-PYRAN-4-YL)METHANOLRelated Search:

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(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL

(TETRAHYDRO-PYRAN-4-YL)-METHANOL

TETRAHYDROPYRAN-4-METHANOL

TERTAHYDROPYRAN-4-METHANOL

4-(Hydroxymethyl)tetrahydro-2H-pyran

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(Tetrahydro-pyran-4-yl)-methanol ,97%

oxan-4-ylMethanol

4-(Hydroxymethyl)tetrahydropyran

4-(Hydroxymethyl)tetrahyd...

tetrahydro-2H-pyran-4-ylmethanol(SALTDATA: FREE)

(TETRAHYDRO-2H-PYRAN-4-YL)METHANO

(Tetrahydro-2H-pyran-4-yl)methanol, (Oxan-4-yl)methanol

Tetrahydropyran-4-Methano

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4-(Hydroxymethyl)tetrahydro-2H-pyran98%

15N]-Ammonium Chloride

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(tetrahydrogen-2h-pyran-4-yl) methanol "

Tetrahydro-4-hydroxymethyl-2H-pyran

(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL ISO 9001：2015 REACH

Tetrahydropyran-4-methanol?New

Chemicalbook4-(Hydroxymethyl)tetrahydro-2H-pyran

4-(Hydroxymethyl)tetrahydropyran, 98%

Tetrahydropyran-4-methanol (Tetrahydro-2H-pyran-4-yl)methanol

14774-37-9

Pyrans, Piperidines &Piperazines

Pyrans, Piperidines & Piperazines

Heterocycles series

Hydroxymethyl's

Alcohols and Derivatives

blocks

Heterocycles