Ryanodine

Product Name: Ryanodine
CAS No.: 15662-33-6
Chemical Name: Ryanodine
Synonyms: Ryanex;ryania;RYANADOL;ryanexel;Ryanexcel;Ryanicide;RYANODINE;bonideryatox;ryaniapowder;Ryanodine,99%
CBNumber: CB1480087
Molecular Formula: C25H35NO9
Formula Weight: 493.55
MOL File: 15662-33-6.mol

More

Less

Ryanodine Property

alpha: D25 +26° (methanol)
Boiling point:: 586.95°C (rough estimate)
Density: 1.2805 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: White solid
Melting point:: 219-220 °C
pka: 10.66±0.70(Predicted)
color: white to beige
CAS DataBase Reference: 15662-33-6
EPA Substance Registry System: Ryanodine (15662-33-6)

More

Less

Safety

Hazard Codes: Xn,N
Risk Statements: 21/22-50/53
Safety Statements: 36/37-60-61
RIDADR: UN 3077 9/PG 3
RTECS: VM4025000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 559276
Product name: Ryanodine, High Purity - CAS 15662-33-6 - Calbiochem
Purity: Naturally occurring alkaloid that blocks the release of Ca2+ from the sarcoplasmic reticulum.
Packaging: 500μg
Price: $265
Updated: 2024/03/01

Tocris

Product number: 1329
Product name: Ryanodine
Purity: ≥98%(HPLC)
Packaging: 1
Price: $214
Updated: 2021/12/16

Usbiological

Product number: 256544
Product name: Ryanodine
Packaging: 1mg
Price: $466
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FR30087
Product name: Ryanodine
Packaging: 1mg
Price: $700
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FR30087
Product name: Ryanodine
Packaging: 2mg
Price: $1100
Updated: 2021/12/16

More

Less

Ryanodine Chemical Properties,Usage,Production

Description

Ryania insecticide is the ground stem wood of the tropical tree Ryania speciosa Vahl., and it contains over a dozen of several structurally related alkaloids. Nowadays, this botanical preparation is of minor importance, but one of its major ingredients, ryanodine, is a widely used pharmacological tool in studies of the calcium release channels in sarcoplasmic reticulum membranes of skeletal and cardiac muscle of both insects and mammals (11,12).

Chemical Properties

white to off-white solid

Uses

Ryanodine is a potent inhibitor of Ca2+ release from sarcoplasmic reticulum with potential application towards the treatment of huntingtons disease.

Uses

Insecticide.

Definition

ChEBI: An insecticide alkaloid isolated from South American plant Ryania speciosa.

Biological Activity

Potent inhibitor of Ca 2+ release from sarcoplasmic reticulum (IC 50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).

storage

-20°C (desiccate)

References

Rogers et ai., J. Amer. Chem. Soc., 70, 3086 (1948)
Kelly, Whittingham, Wusner., Chem. Ind., 857 (1952)
Structure:
Wiesner, Valenta, Findlay., Tetrahedron Lett., 221 (1967)
Hollstein, Rapoport.,J. Amer. Chem. Soc., 90,3864 (1968)
Wong, Hollstein, Rapoport., ibid, 90, 3866 (1968)
Wiesner., Collect. Czech. Chem. Commun., 33, 2656 (1968)
Crystal structure:
Srivastava, Przybylska., Can. J. Chem., 46,795 (1968)

Ryanodine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Ryanodine Suppliers

China 72 France 1 Germany 2 India 1 Japan 3 Switzerland 3 United Kingdom 12 United States 19 Global 113

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Ascent Scientific

Tel: 4401179829988
Fax: 4402030 700 369
Email: customerservice@ascentscientific.co.uk
Country: United Kingdom
ProdList: 279
Advantage: 60

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7892
Advantage: 56

Biyu Biotechnology (Shanghai) Co., ltd

Tel: 021-26018599
Country: China
ProdList: 270
Advantage: 56

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9293
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15085
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 55827
Advantage: 58

15662-33-6, RyanodineRelated Search:

CYCLODODECYL FORMATE CYCLODODECANE CYCLOOCTANEMETHANOL 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL Ryanodine 1,4-Cyclohexanedimethanol trans-1,2-Cyclopentanediol CYCLODODECYLMETHYL ETHER CYCLOOCTANOL CIS-1,2-CYCLOOCTANEDIOL (1S)-TRANS-1,2-CYCLOPENTANEDIOL (1R)-TRANS-1,2-CYCLOPENTANEDIOL MONOACETATE (3S,5S)-2,6-Dimethyl-3,5-heptanediol (R,R)-(-)-1,2-CYCLODODECANEDIOL (-)-NEOMENTHOL CIS-P-MENTHANE-3,8-DIOL 3-Deoxyryanodol (S,S)-(+)-1,2-CYCLODODECANEDIOL

Ryanodine, High Purity - CAS 15662-33-6 - Calbiochem

Ryanex

Ryanexcel

Ryanodine,99%

6-(1α,5aβ,8aβ,9-pentahydroxy-7β-isopropyl-2β,5β,8β-trimethylperhydro-8bα,9-epoxy-5,8-ethanocyclopenta[1,2-b]indenyl) pyrrole-2-carboxylate ryania

Ryanodine from Ryania speciosa

Ryanodol 3-(1H-pyrrole-2-carboxylate) from Ryania speciosa

RYANODINE MIXTURE

RYANADOL

RYANADOL 3-(1H-PYRROLE-2-CARBOXYLATE)

Ryania(content>30%)

Ryanicide

RYANODINE

RYANODOL-3-(1H-PYRROLE-2-CARBOXYLATE)

1H-PYRROLE-2-CARBOXYLIC ACID, (3S,4R,4AR,6S,7S,8R,8AS,8BR,9S,9AS)-DODECAHYDRO-4,6,7,8A,8B,9A-HEXAHYDROXY-3,6A,9-TRIMETHYL-7-(1-METHYLETHYL)-6,9-METHANOBENZO[1,2]PENTALENO[1,6-BC]FURAN-8-YL ESTER

3-(1H-PYR-ROLE-2-CARBOXYLATE)

bonideryatox

groundryaniaspecisa(vahl)stemwood(alkoloidryanodine)

ryanexel

1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,6aS,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester

ryania

ryaniapowder

ryaniaspeciosa

ryanodinealkaloid

6-(1alpha,5abeta,8abeta,9-pentahydroxy-7beta-isopropyl-2beta,5beta,8beta-trimethylperhydro-8balpha,9-epoxy-5,8-ethanocyclopenta[1,2-b]indenyl) pyrrole-2-carboxylate

RYANODINE >98% (RYANADOL, 3-(1H-PYRR

RYANODINE FROM RYANIA SPECIOSA MINIMUM &

RYANODINE FROM RYANIA SPECIOSA INHIBITS CALCIUM RELEASE FROM THE SARCOPLASMIC RETICULUM

RYANODINE FROM RYANIA SPECIOSA A MIXTURE OF RYANODINE AND 9,21-DEHYDRORYANODINE (1:1)

RYANODINE HIGH PURITY

1H-Pyrrole-2-carboxylicacid(3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethy]

9,21-DEHYDRO(RG)

15662-33-6

C25H35NO9

Signalling

Alkaloids

InsP3/Ryanodine receptor