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Ryanodine

Product Name
Ryanodine
CAS No.
15662-33-6
Chemical Name
Ryanodine
Synonyms
Ryanex;ryania;RYANADOL;ryanexel;Ryanexcel;Ryanicide;RYANODINE;bonideryatox;ryaniapowder;Ryanodine,99%
CBNumber
CB1480087
Molecular Formula
C25H35NO9
Formula Weight
493.55
MOL File
15662-33-6.mol
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Ryanodine Property

alpha 
D25 +26° (methanol)
Boiling point:
586.95°C (rough estimate)
Density 
1.2805 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
White solid
Melting point:
219-220 °C
pka
10.66±0.70(Predicted)
color 
white to beige
CAS DataBase Reference
15662-33-6
EPA Substance Registry System
Ryanodine (15662-33-6)
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Safety

Hazard Codes 
Xn,N
Risk Statements 
21/22-50/53
Safety Statements 
36/37-60-61
RIDADR 
UN 3077 9/PG 3
RTECS 
VM4025000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
559276
Product name
Ryanodine, High Purity - CAS 15662-33-6 - Calbiochem
Purity
Naturally occurring alkaloid that blocks the release of Ca2+ from the sarcoplasmic reticulum.
Packaging
500μg
Price
$265
Updated
2024/03/01
Tocris
Product number
1329
Product name
Ryanodine
Purity
≥98%(HPLC)
Packaging
1
Price
$214
Updated
2021/12/16
Usbiological
Product number
256544
Product name
Ryanodine
Packaging
1mg
Price
$466
Updated
2021/12/16
ApexBio Technology
Product number
B5092
Product name
Ryanodine
Packaging
1mg
Price
$314
Updated
2021/12/16
Biosynth Carbosynth
Product number
FR30087
Product name
Ryanodine
Packaging
500ug
Price
$450
Updated
2021/12/16
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Ryanodine Chemical Properties,Usage,Production

Description

Ryania insecticide is the ground stem wood of the tropical tree Ryania speciosa Vahl., and it contains over a dozen of several structurally related alkaloids. Nowadays, this botanical preparation is of minor importance, but one of its major ingredients, ryanodine, is a widely used pharmacological tool in studies of the calcium release channels in sarcoplasmic reticulum membranes of skeletal and cardiac muscle of both insects and mammals (11,12).

Chemical Properties

white to off-white solid

Uses

Ryanodine is a potent inhibitor of Ca2+ release from sarcoplasmic reticulum with potential application towards the treatment of huntingtons disease.

Uses

Insecticide.

Definition

ChEBI: An insecticide alkaloid isolated from South American plant Ryania speciosa.

Biological Activity

Potent inhibitor of Ca 2+ release from sarcoplasmic reticulum (IC 50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).

storage

-20°C (desiccate)

References

Rogers et ai., J. Amer. Chem. Soc., 70, 3086 (1948)
Kelly, Whittingham, Wusner., Chem. Ind., 857 (1952)
Structure:
Wiesner, Valenta, Findlay., Tetrahedron Lett., 221 (1967)
Hollstein, Rapoport.,J. Amer. Chem. Soc., 90,3864 (1968)
Wong, Hollstein, Rapoport., ibid, 90, 3866 (1968)
Wiesner., Collect. Czech. Chem. Commun., 33, 2656 (1968)
Crystal structure:
Srivastava, Przybylska., Can. J. Chem., 46,795 (1968)

Ryanodine Preparation Products And Raw materials

Raw materials

Preparation Products

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15662-33-6, RyanodineRelated Search:

CYCLODODECYL FORMATE CYCLODODECANE CYCLOOCTANEMETHANOL 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL Ryanodine 1,4-Cyclohexanedimethanol trans-1,2-Cyclopentanediol CYCLODODECYLMETHYL ETHER CYCLOOCTANOL CIS-1,2-CYCLOOCTANEDIOL (1S)-TRANS-1,2-CYCLOPENTANEDIOL (1R)-TRANS-1,2-CYCLOPENTANEDIOL MONOACETATE (3S,5S)-2,6-Dimethyl-3,5-heptanediol (R,R)-(-)-1,2-CYCLODODECANEDIOL (-)-NEOMENTHOL CIS-P-MENTHANE-3,8-DIOL 3-Deoxyryanodol (S,S)-(+)-1,2-CYCLODODECANEDIOL

  • Ryanodine, High Purity - CAS 15662-33-6 - Calbiochem
  • Ryanex
  • Ryanexcel
  • Ryanodine,99%
  • 6-(1α,5aβ,8aβ,9-pentahydroxy-7β-isopropyl-2β,5β,8β-trimethylperhydro-8bα,9-epoxy-5,8-ethanocyclopenta[1,2-b]indenyl) pyrrole-2-carboxylate ryania
  • Ryanodine from Ryania speciosa
  • Ryanodol 3-(1H-pyrrole-2-carboxylate) from Ryania speciosa
  • RYANODINE MIXTURE
  • RYANADOL
  • RYANADOL 3-(1H-PYRROLE-2-CARBOXYLATE)
  • Ryania(content>30%)
  • Ryanicide
  • RYANODINE
  • RYANODOL-3-(1H-PYRROLE-2-CARBOXYLATE)
  • 1H-PYRROLE-2-CARBOXYLIC ACID, (3S,4R,4AR,6S,7S,8R,8AS,8BR,9S,9AS)-DODECAHYDRO-4,6,7,8A,8B,9A-HEXAHYDROXY-3,6A,9-TRIMETHYL-7-(1-METHYLETHYL)-6,9-METHANOBENZO[1,2]PENTALENO[1,6-BC]FURAN-8-YL ESTER
  • 3-(1H-PYR-ROLE-2-CARBOXYLATE)
  • bonideryatox
  • groundryaniaspecisa(vahl)stemwood(alkoloidryanodine)
  • ryanexel
  • 1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,6aS,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester
  • ryania
  • ryaniapowder
  • ryaniaspeciosa
  • ryanodinealkaloid
  • 6-(1alpha,5abeta,8abeta,9-pentahydroxy-7beta-isopropyl-2beta,5beta,8beta-trimethylperhydro-8balpha,9-epoxy-5,8-ethanocyclopenta[1,2-b]indenyl) pyrrole-2-carboxylate
  • RYANODINE >98% (RYANADOL, 3-(1H-PYRR
  • RYANODINE FROM RYANIA SPECIOSA MINIMUM &
  • RYANODINE FROM RYANIA SPECIOSA INHIBITS CALCIUM RELEASE FROM THE SARCOPLASMIC RETICULUM
  • RYANODINE FROM RYANIA SPECIOSA A MIXTURE OF RYANODINE AND 9,21-DEHYDRORYANODINE (1:1)
  • RYANODINE HIGH PURITY
  • 1H-Pyrrole-2-carboxylicacid(3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethy]
  • 9,21-DEHYDRO(RG)
  • Ryanodine, Ca2+ release modulator
  • 15662-33-6
  • C25H35NO9
  • Signalling
  • Alkaloids
  • InsP3/Ryanodine receptor