ChemicalBook > CAS DataBase List > TETRODOTOXIN CITRATE

TETRODOTOXIN CITRATE

Product Name
TETRODOTOXIN CITRATE
CAS No.
18660-81-6
Chemical Name
TETRODOTOXIN CITRATE
Synonyms
TETRODOTOXIN;TETRODOTOXIN CITRATE;citratodetetrodotoxina;tetrodotoxin,citrate(1:1)(salt);Tetrodotoxin(TTX), with citrate;Citrato de tetrodotoxina [spanish];Tetrodotoxin, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) (9ci);Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentolcitrat;OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE;(5R,6R,7S,9R,11R,12R,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol 2-hydroxypropane-1,2,3-tricarboxylate (1:1) (non-preferred name)
CBNumber
CB2192024
Molecular Formula
C17H25N3O15
Formula Weight
511.39
MOL File
18660-81-6.mol
More
Less

TETRODOTOXIN CITRATE Property

storage temp. 
Desiccate at -20°C
solubility 
Citrate Buffer (pH 4.8): 30 mg/ml (100 mM)
form 
A solid
pka
8.76(at 25℃)
Water Solubility 
Soluble to 100 mM in water
Stability:
Unstable in Acidic solution, Unstable In Acidic Solution
More
Less

Safety

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
22-36/37/39-45
RTECS 
IO1450000
Toxicity
A toxin contained in the ovary and liver of puffer fish, in the eggs of the California newt and in some other animals. It is used as a chemical tool for the study of ion channels. The s.c. LD50 in mice is 10 mg/kg. It is a toxicant of nerve and muscle by blocking sodium channels, this action causing nerve and muscle paralysis. Symptoms include weakening of voluntary muscles, respiratory failure from paralysis of the diaphragm and hypotension. There is no antidote. Therapy involves artificial respiration.
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
14964
Product name
Tetrodotoxin (citrate)
Packaging
1mg
Price
$254
Updated
2024/03/01
Tocris
Product number
1078
Product name
Tetrodotoxin
Packaging
1
Price
$231
Updated
2021/12/16
Tocris
Product number
1069
Product name
Tetrodotoxincitrate
Packaging
1
Price
$242
Updated
2021/12/16
Biosynth Carbosynth
Product number
FT64082
Product name
Tetrodotoxin citrate
Packaging
1mg
Price
$200
Updated
2021/12/16
Biosynth Carbosynth
Product number
FT64082
Product name
Tetrodotoxin citrate
Packaging
2mg
Price
$340
Updated
2021/12/16
More
Less

TETRODOTOXIN CITRATE Chemical Properties,Usage,Production

Description

TTX is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (Nav) channels, blocking nerve and muscle action potentials. It inhibits the Nav current in frog muscle and squid axon with IC50 values of 4.1 and 5.2 nM, respectively, and binds to rat brain membranes with a Kd value of 1.8 nM. TTX was used in Hodgkin and Huxley’s classic experiments to elucidate the physical biology of nerve action potentials and remains an indispensible neuroscience tool to pharmacologically dissect the contribution of the Nav current in excitable neurons and to rationally design compounds for the treatment of neuropathic pain. This citrate-stabilized form of TTX is designed for improved solubility over pure TTX , which is insoluble in water and most organic solvents. This preparation of TTX citrate consists of TTX that has been dissolved in a citrate solution and then lyophilized.

Uses

Tetrodotoxin Citrate is a highly selective, reversible sodium channel blocker.

Biological Activity

Highly selective, reversible sodium channel blocker; citrate salt of tetrodotoxin.

storage

Store at -20°C

TETRODOTOXIN CITRATE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

TETRODOTOXIN CITRATE Suppliers

China 24 China Hong Kong 1 Europe 1 Germany 3 India 1 Japan 1 Switzerland 1 United Kingdom 3 United States 6 Global 41
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8449
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
Country
China
ProdList
55717
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
CHINA
ProdList
52867
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6313
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11289
Advantage
58
TopScience Biochemical
Tel
00852-68527855
Fax
00852-26406298
Email
info@itopbiochem.com
Country
China Hong Kong
ProdList
902
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
Changzhou Xianglong Pharmaceutical Technology Co., LTD
Tel
18661161657
Email
yaoxiangqiu2021@163.com
Country
China
ProdList
10066
Advantage
58

18660-81-6, TETRODOTOXIN CITRATERelated Search:

Ammonium citrate tribasic (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL Ammonium citrate dibasic TETRODOTOXIN CITRATE (TETRAHYDRO-2H-PYRAN-3-YL)METHANAMINE HYDROCHLORIDE 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL 1,4-Cyclohexanedimethanol 2-Amino-2-ethyl-1,3-propanediol TRANS-2-AMINOMETHYL-1-CYCLOHEXANOL 4-(2-AMINOETHYL)TETRAHYDROPYRAN BIS(3-AMINOPROPYL) ETHER ACONITINE TETRODOTOXIN-SENSITIV TETRODOTOXIN 5,5-DIETHOXYPENTAN-1-OL TRANS-4-(METHYLAMINO)CYCLOHEXANOL METHYL-(TETRAHYDRO-PYRAN-3-YLMETHYL)-AMINE N-CYCLOHEXYL-GUANIDINE CIS-2-METHYLAMINO-CYCLOHEXANOL

  • TETRODOTOXIN
  • TETRODOTOXIN CITRATE
  • OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE
  • citratodetetrodotoxina
  • tetrodotoxin,citrate(1:1)(salt)
  • Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentolcitrat
  • Citrato de tetrodotoxina [spanish]
  • Tetrodotoxin, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) (9ci)
  • Tetrodotoxin(TTX), with citrate
  • (5R,6R,7S,9R,11R,12R,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol 2-hydroxypropane-1,2,3-tricarboxylate (1:1) (non-preferred name)
  • 18660-81-6
  • C11H17N3O8C6H8O7
  • C17H25N3O15
  • Sodium channel