TRANS-4-(METHYLAMINO)CYCLOHEXANOL

Product Name: TRANS-4-(METHYLAMINO)CYCLOHEXANOL
CAS No.: 22348-44-3
Chemical Name: TRANS-4-(METHYLAMINO)CYCLOHEXANOL
Synonyms: trans-4-(Methylamino);TRANS-4-(METHYLAMINO)CYCLOHEXANOL;(1r,4r)-4-(MethylaMino)cyclohexanol;trans-4-(Methylamino)cyclohexan-1-ol;Cyclohexanol, 4-(methylamino)-, trans-;rel-(1R,4R)-4-(methylamino)cyclohexan-1-ol
CBNumber: CB82453321
Molecular Formula: C7H15NO
Formula Weight: 129.2
MOL File: 22348-44-3.mol

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TRANS-4-(METHYLAMINO)CYCLOHEXANOL Property

Boiling point:: 211.7±33.0 °C(Predicted)
Density: 0.97±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 15.17±0.40(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2922190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

SynQuest Laboratories

Product number: 4256-1-71
Product name: trans-4-Methylamino-cyclohexanol
Purity: 97.0%
Packaging: 250mg
Price: $115
Updated: 2021/12/16

Matrix Scientific

Product number: 122643
Product name: trans-4-Methylamino-cyclohexanol
Purity: 97.0%
Packaging: 1g
Price: $182
Updated: 2021/12/16

ChemScene

Product number: CS-W019271
Product name: trans-4-(Methylamino)cyclohexanol
Packaging: 5g
Price: $251
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4256-1-71
Product name: trans-4-Methylamino-cyclohexanol
Purity: 97.0%
Packaging: 1g
Price: $290
Updated: 2021/12/16

AK Scientific

Product number: 1297AB
Product name: trans-4-(Methylamino)cyclohexanol
Packaging: 10g
Price: $424
Updated: 2021/12/16

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TRANS-4-(METHYLAMINO)CYCLOHEXANOL Chemical Properties,Usage,Production

Synthesis

111300-06-2

22348-44-3

The general procedure for the synthesis of trans-4-methylaminocyclohexanol from trans-4-BOC-aminocyclohexanol was as follows: lithium aluminum hydride (9 g, 0.23 mol) was suspended in dry tetrahydrofuran (425 mL) under argon protection. Trans-4-(tert-butoxycarbonylamino)cyclohexanol (Intermediate 1, 10 g, 0.046 mol) was slowly added under cooling in an ice bath. After addition, the ice bath was withdrawn and the reaction mixture was heated to reflux and kept at reflux overnight. Upon completion of the reaction, the mixture was cooled to room temperature, followed by careful sequential dropwise addition of 9 mL of water, 9 mL of 4N NaOH solution and 18 mL of water under stirring to quench the reaction. The organic solvent was removed by distillation under reduced pressure and the resulting crude product was dissolved in chloroform and dried with anhydrous magnesium sulfate. After filtration, the filtrate was concentrated to dryness under reduced pressure and finally co-evaporated with hexane to afford trans-4-methylaminocyclohexanol as a white solid in 89% yield. The structure of this intermediate was confirmed by 1H NMR (300 MHz, chloroform-d), δppm 1.04-1.20 (m, 2H), 1.25-1.40 (m, 2H), 1.97 (br.s., 4H), 2.27-2.40 (m, 1H), 3.57-3.70 (m, 1H).

References

[1] Patent: EP2386555, 2011, A1. Location in patent: Paragraph 0074
[2] Patent: EP2592077, 2013, A1. Location in patent: Paragraph 0129
[3] Patent: WO2013/68552, 2013, A1. Location in patent: Page/Page column 39
[4] Patent: US2017/313683, 2017, A1. Location in patent: Paragraph 0356-0358

TRANS-4-(METHYLAMINO)CYCLOHEXANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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TRANS-4-(METHYLAMINO)CYCLOHEXANOL Suppliers

China 58 India 1 United States 8 Global 67

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22348-44-3, TRANS-4-(METHYLAMINO)CYCLOHEXANOLRelated Search:

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TRANS-4-(METHYLAMINO)CYCLOHEXANOL

(1r,4r)-4-(MethylaMino)cyclohexanol

trans-4-(Methylamino)cyclohexan-1-ol

trans-4-(Methylamino)

Cyclohexanol, 4-(methylamino)-, trans-

rel-(1R,4R)-4-(methylamino)cyclohexan-1-ol

22348-44-3