TRANS-4-(METHYLAMINO)CYCLOHEXANOL

TRANS-4-(METHYLAMINO)CYCLOHEXANOL Property

Boiling point:

211.7±33.0 °C(Predicted)

Density 

0.97±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

15.17±0.40(Predicted)

Appearance

White to off-white Solid

Safety

HS Code 

2922190090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

TRANS-4-(METHYLAMINO)CYCLOHEXANOL Chemical Properties,Usage,Production

Synthesis

The general procedure for the synthesis of trans-4-methylaminocyclohexanol from trans-4-BOC-aminocyclohexanol was as follows: lithium aluminum hydride (9 g, 0.23 mol) was suspended in dry tetrahydrofuran (425 mL) under argon protection. Trans-4-(tert-butoxycarbonylamino)cyclohexanol (Intermediate 1, 10 g, 0.046 mol) was slowly added under cooling in an ice bath. After addition, the ice bath was withdrawn and the reaction mixture was heated to reflux and kept at reflux overnight. Upon completion of the reaction, the mixture was cooled to room temperature, followed by careful sequential dropwise addition of 9 mL of water, 9 mL of 4N NaOH solution and 18 mL of water under stirring to quench the reaction. The organic solvent was removed by distillation under reduced pressure and the resulting crude product was dissolved in chloroform and dried with anhydrous magnesium sulfate. After filtration, the filtrate was concentrated to dryness under reduced pressure and finally co-evaporated with hexane to afford trans-4-methylaminocyclohexanol as a white solid in 89% yield. The structure of this intermediate was confirmed by 1H NMR (300 MHz, chloroform-d), δppm 1.04-1.20 (m, 2H), 1.25-1.40 (m, 2H), 1.97 (br.s., 4H), 2.27-2.40 (m, 1H), 3.57-3.70 (m, 1H).

References

[1] Patent: EP2386555, 2011, A1. Location in patent: Paragraph 0074
[2] Patent: EP2592077, 2013, A1. Location in patent: Paragraph 0129
[3] Patent: WO2013/68552, 2013, A1. Location in patent: Page/Page column 39
[4] Patent: US2017/313683, 2017, A1. Location in patent: Paragraph 0356-0358