Tetrahydro-4-pyranol

Product Name: Tetrahydro-4-pyranol
CAS No.: 2081-44-9
Chemical Name: Tetrahydro-4-pyranol
Synonyms: TETRAHYDRO-2H-PYRAN-4-OL;Oxan-4-ol;TETRAHYDRO-4H-PYRAN-4-OL;POH;Tetrahydropyran-4-ol;4-HYDROXYTETRAHYDROPYRAN;2H-Pyran-4-ol;Tetrahydropyranol;4-tetrahydropyranol;Tetrahydro-4-pranol
CBNumber: CB0747105
Molecular Formula: C5H10O2
Formula Weight: 102.13
MOL File: 2081-44-9.mol

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Tetrahydro-4-pyranol Property

Boiling point:: 87 °C/15 mmHg (lit.)
Density: 1.071 g/mL at 25 °C (lit.)
refractive index: n20/D 1.462(lit.)
Flash point:: 190 °F
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, Methanol
form: Oil
pka: 14.61±0.20(Predicted)
color: Clear Colourless
BRN: 102736
InChI: InChI=1S/C5H10O2/c6-5-1-3-7-4-2-5/h5-6H,1-4H2
InChIKey: LMYJGUNNJIDROI-UHFFFAOYSA-N
SMILES: C1OCCC(O)C1
LogP: -0.440 (est)
CAS DataBase Reference: 2081-44-9(CAS DataBase Reference)
NIST Chemistry Reference: Tetrahydro-4H-pyran-4-ol(2081-44-9)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 41-36/37/38-20/22
Safety Statements: 26-39-36/37/39-23
RIDADR: 1993
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 198234
Product name: Tetrahydro-4-pyranol
Purity: 98%
Packaging: 5g
Price: $102.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 198234
Product name: Tetrahydro-4-pyranol
Purity: 98%
Packaging: 1g
Price: $44.4
Updated: 2023/06/20

TCI Chemical

Product number: T2825
Product name: Tetrahydro-4-pyranol
Purity: >97.0%(GC)
Packaging: 1g
Price: $22
Updated: 2025/07/31

TCI Chemical

Product number: T2825
Product name: Tetrahydro-4-pyranol
Purity: >97.0%(GC)
Packaging: 5g
Price: $47
Updated: 2025/07/31

TRC

Product number: T295460
Product name: Tetrahydro-4-pyranol
Packaging: 1g
Price: $110
Updated: 2021/12/16

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Tetrahydro-4-pyranol Chemical Properties,Usage,Production

Chemical Properties

Colorless transparent liquid

Uses

Tetrahydro-4-pyranol (4-Hydroxytetrahydropyran) was used in the quantitative analysis of 3-hydroxytetrahydropyran (3-HTHP).

Uses

Tetrahydro-4-pyranol is a building block of various organic compounds and pharmaceuticals.

Synthesis

29943-42-8

2081-44-9

General procedure for the synthesis of tetrahydropyran-4-ol from tetrahydropyranone: To a tetrahydrofuran (THF, 25 mL) solution of tetrahydropyranone (5.0 g, 50 mmol), which was cooled to 0 °C, a THF (50 mL) suspension of lithium aluminum hydride (LiAlH4, 3.8 g, 0.1 mol) was slowly added. The reaction mixture was stirred at 0 °C for 30 min, followed by sequential addition of water (3.8 mL), 15% aqueous sodium hydroxide (NaOH) solution (3.8 mL) and water (11.4 mL) to quench the reaction. The mixture was filtered and the solid was washed with ethyl acetate (70 mL x 2). The filtrates were combined and evaporated to give tetrahydropyran-4-ol (5.09 g, 99% yield).

References

[1] Patent: WO2008/88881, 2008, A1. Location in patent: Page/Page column 39
[2] Patent: US9301951, 2016, B2. Location in patent: Page/Page column 125
[3] Chemistry - A European Journal, 2018, vol. 24, # 62, p. 16526 - 16531
[4] Patent: US2010/76029, 2010, A1. Location in patent: Page/Page column 35
[5] Patent: US2011/71196, 2011, A1. Location in patent: Page/Page column 18-19

Tetrahydro-4-pyranol Preparation Products And Raw materials

Raw materials

Ethylene Phosphoric acid Sodium phosphate monobasic Aluminum chloride Tetrahydrofuran Diethyl ether Lithium Aluminum Hydride Hydrochloric acid Dichloromethane Sodium hydroxide 3-Chloropropionyl chloride Magnesium sulfate

Preparation Products

4-BROMO-TETRAHYDROPYRAN 1-(Tetrahydro-2H-pyran-4-yl)hydrazine

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Tetrahydro-4-pyranol Suppliers

Austria 1 Belgium 1 Canada 1 China 270 France 1 Germany 3 India 9 Japan 4 Slovakia 1 Switzerland 1 United Kingdom 6 United States 29 USA 1 Global 328

ITIC MEDCHEM(SUZHOU) CO.,LTD.

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Energy Chemical

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View Lastest Price from Tetrahydro-4-pyranol manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Tetrahydro-4-pyranol 2081-44-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 30tons/month
Release date: 2023-02-22

Hebei Chuanghai Biotechnology Co., Ltd

Product: Tetrahydro-4-pyranol 2081-44-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-10

Henan Aochuang Chemical Co.,Ltd.

Product: Tetrahydro-4-pyranol 2081-44-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

2081-44-9, Tetrahydro-4-pyranolRelated Search:

Tetrahydro-4H-pyran-4-one Tetrahydro-2H-pyran-4-carboxylic acid 2H-PYRAN-2-CARBONITRILE, TETRAHYDRO- Pyrrolidine Tetrahydrofuran [(Tetrahydro-2H-pyran-4-yl)methyl]hydrazine dihydrochloride Tetrahydropyran Centchroman 4-Aminotetrahydropyran TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE Oxan-4-yl 4-methylbenzenesulfonate Tetrahydro-2H-pyran-4-carbonyl chloride Hexahydro-3H-pyrrolo[1,2-c]imidazole-1,3-dione TETRAHYDROTHIOPYRAN-4-OL 97 TETRAHYDRO-2H-PYRAN-3-CARBOXYLIC ACID 1,1-Dioxo-hexahydro-1l6-thiopyran-4-carboxylic acid Tetrahydropyranyl-4-acetic acid

2H-PYRAN-4-OL, TETRAHYDRO

4-HYDROXYTETRAHYDROPYRAN

TETRAHYDRO-2H-PYRAN-4-OL

TETRAHYDRO-4H-PYRAN-4-OL

TETRAHYDRO-4-PYRANOL

Tetrahydropyran-4-ol

POH

4-HYDROXYTETRAHYDROPYAN

4-Hydroxytetrahydro-2H-pyran

2H-Pyran-4-ol

Oxan-4-ol

Tetrahydro-2H-pyran-4-ol, 97+%

Tetrahydro-4-pyranol,4-Hydroxytetrahydropyran

4-Hydroxytetrahydro-2H-pyran 97%

3,4,5,6-Tetrahydro-2H-pyran-4-ol

Tetrahydro-2H-pyran-4-ol, 4-Hydroxyoxane

4-tetrahydropyranol

Tetrahydro-4-pranol

Tetrahydro-4-pyranol 98%

Tetrahydro-4-pyranol ISO 9001：2015 REACH

TIANFU CHEM-Tetrahydro-4-pyranol

Tetrahydropyranol

Tetrahydro-4-pyranol,98%

2081-44-9

2081-44-5

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