4-Aminotetrahydropyran
Description- Product Name
- 4-Aminotetrahydropyran
- CAS No.
- 38041-19-9
- Chemical Name
- 4-Aminotetrahydropyran
- Synonyms
- TETRAHYDRO-2H-PYRAN-4-AMINE;oxan-4-amine;TETRAHYDRO-PYRAN-4-YLAMINE;4-Aminotetrahyropyran;4-AMINOTETRAHYDROPYRAN;Tetrahydropyran-4-amine;Noe Marioni, M.D., PLLC;4-Aminotetrahydro-2H-pyran;4-Aminotetrahydropyran?New;2H-PYRAN-4-AMINE, TETRAHYDRO-
- CBNumber
- CB4376785
- Molecular Formula
- C5H11NO
- Formula Weight
- 101.15
- MOL File
- 38041-19-9.mol
4-Aminotetrahydropyran Property
- Boiling point:
- 60 °C
- Density
- 0.977 g/cm3 at 25 °C
- refractive index
- n20/D 1.463
- Flash point:
- 54°C
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- pka
- 9.63±0.20(Predicted)
- form
- liquid
- color
- Colourless
- InChI
- InChI=1S/C5H11NO/c6-5-1-3-7-4-2-5/h5H,1-4,6H2
- InChIKey
- AHVQYHFYQWKUKB-UHFFFAOYSA-N
- SMILES
- C1OCCC(N)C1
- CAS DataBase Reference
- 38041-19-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 10-34-41-22-37/18
- Safety Statements
- 16-26-36/37/39-39
- RIDADR
- 2734
- WGK Germany
- 1
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 29321900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 711357
- Product name
- 4-Aminotetrahydropyran
- Purity
- 97%
- Packaging
- 1g
- Price
- $157
- Updated
- 2025/07/31
- Product number
- A2060
- Product name
- Tetrahydro-2H-pyran-4-amine
- Purity
- min. 95.0 %
- Packaging
- 5G
- Price
- $65
- Updated
- 2025/07/31
- Product number
- A2060
- Product name
- Tetrahydro-2H-pyran-4-amine
- Purity
- min. 95.0 %
- Packaging
- 25G
- Price
- $213
- Updated
- 2025/07/31
- Product number
- A630040
- Product name
- 4-Aminotetrahydropyran
- Packaging
- 5g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 012574
- Product name
- 4-Aminotetrahydropyran
- Purity
- 98%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
4-Aminotetrahydropyran Chemical Properties,Usage,Production
Description
4-Aminotetrahydropyran contains the tetrahydropyran ring, which is the most frequently reported three-dimensional ring system in marketed drugs, and is second only to the phenyl ring when two-dimensional rings are included. It can be used as reactant/reagent in synthesis of aminothiazole compounds for use in treatment of cancer. Its scaffold is very useful in the drug discovery for cancer treatment.
Application
4-Aminotetrahydropyran can be used as reactant/reagent in synthesis of aminothiazole compounds for use in treatment of cancer.
Synthesis
61128-73-2
38041-19-9
General procedure for the synthesis of 4-aminotetrahydropyran from dihydro-2H-pyran-4(3H)-one oxime: Raney Ni (10%) was added to a stirred solution of compound 2.2 (1.0 g, 8.7 mmol) in methanol (50 mL) and the resulting mixture was stirred for 5 hr at room temperature in a hydrogen atmosphere. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the catalyst was removed by filtration and the methanol solvent in the filtrate was concentrated in vacuum to afford the target product 4-aminotetrahydropyran (Compound 2.3, 0.5 g, 57% yield).
References
[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 7, p. 2210 - 2221
[2] Patent: US2009/82423, 2009, A1. Location in patent: Page/Page column 23
[3] Patent: US5707989, 1998, A
[4] Patent: US5821240, 1998, A
[5] Patent: US5977102, 1999, A
4-Aminotetrahydropyran Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Aminotetrahydropyran manufacturers
- Product
- 4-Aminotetrahydropyran 38041-19-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-22
- Product
- 4-Aminotetrahydropyran 38041-19-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-11
- Product
- 4-Aminotetrahydropyran 38041-19-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19