3-Chloropropionyl chloride
- Product Name
- 3-Chloropropionyl chloride
- CAS No.
- 625-36-5
- Chemical Name
- 3-Chloropropionyl chloride
- Synonyms
- 3-Chloropropanoyl chloride;Chloropropionyl chloride;oropropionyL;3-Chloropropionyl ch;3-Chlorpropionylchlorid;-Chloropropanoylchloride;3-Chloropropinyl chloride;3-chloro-propanoylchlorid;3'ChloropropionylChloride;3-CHLOROPROPIONYL CHLORIDE
- CBNumber
- CB8691211
- Molecular Formula
- C3H4Cl2O
- Formula Weight
- 126.97
- MOL File
- 625-36-5.mol
3-Chloropropionyl chloride Property
- Melting point:
- -32 °C
- Boiling point:
- 143-145 °C(lit.)
- Density
- 1.33 g/mL at 25 °C(lit.)
- vapor pressure
- 10.0 hPa
- refractive index
- n20/D 1.457(lit.)
- RTECS
- UC3934000
- Flash point:
- 146 °F
- storage temp.
- Flammables area
- solubility
- Chloroform, Ethyl Acetate
- form
- liquid
- color
- red-brown
- PH
- <7 (H2O)
- explosive limit
- 8.8-20.2%(V)
- Water Solubility
- reacts
- Sensitive
- Moisture Sensitive
- BRN
- 635814
- Stability:
- Moisture Sensitive
- InChIKey
- INUNLMUAPJVRME-UHFFFAOYSA-N
- CAS DataBase Reference
- 625-36-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Propanoyl chloride, 3-chloro-(625-36-5)
- EPA Substance Registry System
- Propanoyl chloride, 3-chloro- (625-36-5)
Safety
- Hazard Codes
- T+
- Risk Statements
- 14-22-26-34-35-10
- Safety Statements
- 23-26-36/37/39-45-38-16-8
- RIDADR
- UN 3390 6.1/PG 1
- WGK Germany
- 1
- F
- 21
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- I
- HS Code
- 29159080
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H330Fatal if inhaled
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C69128
- Product name
- 3-Chloropropionyl chloride
- Purity
- 98%
- Packaging
- 100g
- Price
- $137
- Updated
- 2024/03/01
- Product number
- 147443
- Product name
- 3-Chloropropionyl chloride
- Purity
- technical grade
- Packaging
- 100ml
- Price
- $56.4
- Updated
- 2024/03/01
- Product number
- B25698
- Product name
- 3-Chloropropionyl chloride, 97%
- Packaging
- 100g
- Price
- $78.8
- Updated
- 2024/03/01
- Product number
- C380600
- Product name
- 3-Chloropropionyl chloride
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC71810
- Product name
- 3-Chloropropionyl chloride
- Packaging
- 50g
- Price
- $50
- Updated
- 2021/12/16
3-Chloropropionyl chloride Chemical Properties,Usage,Production
Description
3-Chloropropionyl chloride is an important bifunctional reagent. It is capable of acylation and possesses a 2-chloro-ethyl fragment (CH2CH2Cl), which can be subjected to nucleophilic substitution and serves as a masked vinyl group. It can be used as a starting material in many reactions to construct a variety of (hetero)cyclic compounds.
Chemical Properties
Clear colorless to dark brown liquid. Soluble in ethanol, ether and chloroform. Slightly soluble in water.
Uses
3-Chloropropionyl chloride is a reagent used in the synthesis of Beclamide (B119400), which is a chlorinated benzylpropanamide used as an anticonvulsant drug. It is used in the treatment of tonic-clonic seizyres and has sedative properties.
Preparation
3-Chloropropionyl chloride (1) is commercially available and can be prepared from β-propiolactone (2) and thionyl chloride.1 Other standard methods available for the preparation of acyl chlorides can also be applied: the reaction of acrylic acid (3) or 3-chloropropionic acid (4) with thionyl chloride, phosphoryl chloride, phosgene, or phosphorus trichloride.
Reactions
(1) The Friedel¨CCrafts acylation of tert-butylbenzene (5) with 3-chloropropionyl chloride (1) followed by cyclization provid- ed indanone 6, which was further transformed into urea derivative 7, a potent TRPV1 antagonist.
(2) A novel high-yielding one-pot microwave-assisted synthesis of condensed 5-substituted pyranoisoquinoline-1,6-diones 9 from 2-substituted isoquinoline-1,3-diones 8 and 3-chloropropionyl chloride (1) was reported.
(3) Acylation of 2-aminophenol (12) with 3-chloropropionyl chloride (1), followed by cyclization in the presence of polyphosphoric acid (PPA), gave benzoxazole 13, which was further reacted with 4-chlorophenyl-1-piperazine to yield the target benzo[d]oxazole analogue 14, a selective dopamine D4 receptor ligand.
Flammability and Explosibility
Non flammable
Synthesis
3-Chloropropionyl chloride is produced by reaction of acrylic acid with hydrogen chloride and phosgene in the presence of, for example,dimethylformamide as catalyst, or by reaction of propiolactone with thionyl chloride.
3-Chloropropionyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Chloropropionyl chloride manufacturers
- Product
- 3-Chloropropionyl chloride 625-36-5
- Price
- US $85.00-25.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-23
- Product
- 3-Chloropropionyl chloride 625-36-5
- Price
- US $9.10/KG
- Min. Order
- 1KG
- Purity
- 99.%
- Supply Ability
- 10 ton
- Release date
- 2024-08-23
- Product
- 3-Chloropropionyl chloride 625-36-5
- Price
- US $8.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-22