ChemicalBook > CAS DataBase List > 3-Chloropropionyl chloride

3-Chloropropionyl chloride

Product Name: 3-Chloropropionyl chloride
CAS No.: 625-36-5
Chemical Name: 3-Chloropropionyl chloride
Synonyms: 3-Chloropropanoyl chloride;Chloropropionyl chloride;oropropionyL;3-Chloropropionyl ch;3-Chlorpropionylchlorid;-Chloropropanoylchloride;3-Chloropropinyl chloride;3-chloro-propanoylchlorid;3'ChloropropionylChloride;3-CHLOROPROPIONYL CHLORIDE
CBNumber: CB8691211
Molecular Formula: C3H4Cl2O
Formula Weight: 126.97
MOL File: 625-36-5.mol

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3-Chloropropionyl chloride Property

Melting point:: -32 °C
Boiling point:: 143-145 °C(lit.)
Density: 1.33 g/mL at 25 °C(lit.)
vapor pressure: 10.0 hPa
RTECS: UC3934000
refractive index: n20/D 1.457(lit.)
Flash point:: 146 °F
storage temp.: Flammables area
solubility: Chloroform, Ethyl Acetate
form: liquid
color: red-brown
PH: <7 (H2O)
explosive limit: 8.8-20.2%(V)
Water Solubility: reacts
Sensitive: Moisture Sensitive
BRN: 635814
Stability:: Moisture Sensitive
InChIKey: INUNLMUAPJVRME-UHFFFAOYSA-N
CAS DataBase Reference: 625-36-5(CAS DataBase Reference)
NIST Chemistry Reference: Propanoyl chloride, 3-chloro-(625-36-5)
EPA Substance Registry System: Propanoyl chloride, 3-chloro- (625-36-5)

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Safety

Hazard Codes: T+
Risk Statements: 14-22-26-34-35-10
Safety Statements: 23-26-36/37/39-45-38-16-8
RIDADR: UN 3390 6.1/PG 1
WGK Germany: 1
F: 21
Autoignition Temperature: 460°C
TSCA: Yes
HazardClass: 6.1
PackingGroup: I
HS Code: 29159080

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C69128
Product name: 3-Chloropropionyl chloride
Purity: 98%
Packaging: 100g
Price: $141
Updated: 2025/07/31

Sigma-Aldrich

Product number: 147443
Product name: 3-Chloropropionyl chloride
Purity: technical grade
Packaging: 100ml
Price: $58.1
Updated: 2025/07/31

TRC

Product number: C380600
Product name: 3-Chloropropionyl chloride
Packaging: 5g
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC71810
Product name: 3-Chloropropionyl chloride
Packaging: 50g
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC71810
Product name: 3-Chloropropionyl chloride
Packaging: 100g
Price: $90
Updated: 2021/12/16

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3-Chloropropionyl chloride Chemical Properties,Usage,Production

Description

3-Chloropropionyl chloride is an important bifunctional reagent. It is capable of acylation and possesses a 2-chloro-ethyl fragment (CH2CH2Cl), which can be subjected to nucleophilic substitution and serves as a masked vinyl group. It can be used as a starting material in many reactions to construct a variety of (hetero)cyclic compounds.

Chemical Properties

Clear colorless to dark brown liquid. Soluble in ethanol, ether and chloroform. Slightly soluble in water.

Uses

3-Chloropropionyl chloride is a reagent used in the synthesis of Beclamide (B119400), which is a chlorinated benzylpropanamide used as an anticonvulsant drug. It is used in the treatment of tonic-clonic seizyres and has sedative properties.

Preparation

3-Chloropropionyl chloride (1) is commercially available and can be prepared from β-propiolactone (2) and thionyl chloride.1 Other standard methods available for the preparation of acyl chlorides can also be applied: the reaction of acrylic acid (3) or 3-chloropropionic acid (4) with thionyl chloride, phosphoryl chloride, phosgene, or phosphorus trichloride.

Reactions

(1) The Friedel¨CCrafts acylation of tert-butylbenzene (5) with 3-chloropropionyl chloride (1) followed by cyclization provid- ed indanone 6, which was further transformed into urea derivative 7, a potent TRPV1 antagonist.

(2) A novel high-yielding one-pot microwave-assisted synthesis of condensed 5-substituted pyranoisoquinoline-1,6-diones 9 from 2-substituted isoquinoline-1,3-diones 8 and 3-chloropropionyl chloride (1) was reported.

(3) Acylation of 2-aminophenol (12) with 3-chloropropionyl chloride (1), followed by cyclization in the presence of polyphosphoric acid (PPA), gave benzoxazole 13, which was further reacted with 4-chlorophenyl-1-piperazine to yield the target benzo[d]oxazole analogue 14, a selective dopamine D4 receptor ligand.

Flammability and Explosibility

Non flammable

Synthesis

3-Chloropropionyl chloride is produced by reaction of acrylic acid with hydrogen chloride and phosgene in the presence of, for example,dimethylformamide as catalyst, or by reaction of propiolactone with thionyl chloride.

References

[1] Patent: WO2005/92842, 2005, A1. Location in patent: Page/Page column 18-19
[2] Angewandte Chemie, 1960, vol. 72, # 22, p. 836 - 845
[3] Patent: US2013/317248, 2013, A1. Location in patent: Paragraph 0061; 0062
[4] Patent: US2013/317252, 2013, A1. Location in patent: Paragraph 0091

3-Chloropropionyl chloride Preparation Products And Raw materials

Raw materials

Benzoyl peroxide Propionyl chloride 3-Chloropropionic acid 2-Chloropropionyl chloride Carbon tetrachloride Sulfuryl chloride Thionyl chloride

Preparation Products

Tetrahydro-4-pyranol 5,6-DIHYDRO-4-METHOXY-2H-PYRAN Tetrahydro-4H-pyran-4-one Moricizine

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View Lastest Price from 3-Chloropropionyl chloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 3-Chloropropionyl chloride 625-36-5
Price: US $85.00-25.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-23

Shaanxi Didu New Materials Co. Ltd

Product: 3-Chloropropionyl chloride 625-36-5
Price: US $14.20/kg
Min. Order: 1kg
Purity: 99.0% Min
Supply Ability: 100 Tons
Release date: 2025-03-27

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Chloropropionyl chloride 625-36-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-05

625-36-5, 3-Chloropropionyl chlorideRelated Search:

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3-CHLOROPROPIONYL CHLORIDE FOR SYNTHESIS

3 - chlorine propionyl chloride

-Chloropropanoylchloride

Chloropropionyl chloride

Propionyl chloride, 3-chloro-

BETA-CHLOROPROPIONYL CHLORIDE

3-Chloropropionyl chlorode

3-CHLOROPROPIONYL CHLORIDE, TECH.

3-ChloropropionylChloride,~97%

3-CHLOROPROPIONYL CHLORIDE

3-CHLOROPROPIONIC ACID CHLORIDE

Propanoyl chloride, 3-chloro-

3-CHLOROPROPIONYL CHLORIDE:SS-CHLOROPROPIONLY CHLORIDE

3-Chloropropionoic acid chloranhydride

b-Chloropropanoyl chloride

3-Chloropropinyl chloride

3-Chlorpropionylchlorid

3-CHLOROPROPIONYL CHLORIDE 99%

3-Chloropropanoyl chloride

3-chloro-propanoylchlorid

beta-Chloropropanoyl chloride

beta-Chloropropionic acid chloride

beta-Chloropropionoyl chloride

3-Chloropropionyl ch

3-Chloropropionyl chloride, 98% 100ML

3-Chloropropionyl chloride,98%

β-Chloropropionly chloride

oropropionyL

3-Chloropropionyl Chloride &gt

3-Chloropropionyl chloride 625-36-5

3-Chloropropionyl chloride625-36-5 CAS NO.625-36-5 CAS NO.625-36-5

6. 3-Chloropropionyl Chloride

3'ChloropropionylChloride

625-36-5

C3H4OCl2

C3H4CI2O

ClCH2CH2COCl

ACID CHLORIDE

Building Blocks

Carbonyl Compounds

Acid Halides

Organic Building Blocks

Halogen compounds

API Intermediate

Pyridines ,Halogenated Heterocycles

Acid Halides

Carbonyl Compounds

Organic Building Blocks