3-Chloropropionyl chloride
- Product Name
- 3-Chloropropionyl chloride
- CAS No.
- 625-36-5
- Chemical Name
- 3-Chloropropionyl chloride
- Synonyms
- 3-Chloropropanoyl chloride;Chloropropionyl chloride;oropropionyL;3-Chloropropionyl ch;3-Chlorpropionylchlorid;-Chloropropanoylchloride;3-Chloropropinyl chloride;3-chloro-propanoylchlorid;3-CHLOROPROPIONYL CHLORIDE;3-Chloropropionyl chlorode
- CBNumber
- CB8691211
- Molecular Formula
- C3H4Cl2O
- Formula Weight
- 126.97
- MOL File
- 625-36-5.mol
3-Chloropropionyl chloride Property
- Melting point:
- -32 °C
- Boiling point:
- 143-145 °C(lit.)
- Density
- 1.33 g/mL at 25 °C(lit.)
- vapor pressure
- 10.0 hPa
- refractive index
- n20/D 1.457(lit.)
- RTECS
- UC3934000
- Flash point:
- 146 °F
- storage temp.
- Flammables area
- solubility
- Chloroform, Ethyl Acetate
- form
- liquid
- color
- red-brown
- PH
- <7 (H2O)
- explosive limit
- 8.8-20.2%(V)
- Water Solubility
- reacts
- Sensitive
- Moisture Sensitive
- BRN
- 635814
- Stability:
- Moisture Sensitive
- InChIKey
- INUNLMUAPJVRME-UHFFFAOYSA-N
- CAS DataBase Reference
- 625-36-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Propanoyl chloride, 3-chloro-(625-36-5)
- EPA Substance Registry System
- Propanoyl chloride, 3-chloro- (625-36-5)
Safety
- Hazard Codes
- T+
- Risk Statements
- 14-22-26-34-35-10
- Safety Statements
- 23-26-36/37/39-45-38-16-8
- RIDADR
- UN 3390 6.1/PG 1
- WGK Germany
- 1
- F
- 21
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- I
- HS Code
- 29159080
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H330Fatal if inhaled
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C69128
- Product name
- 3-Chloropropionyl chloride
- Purity
- 98%
- Packaging
- 100g
- Price
- $137
- Updated
- 2024/03/01
- Product number
- 147443
- Product name
- 3-Chloropropionyl chloride
- Purity
- technical grade
- Packaging
- 100ml
- Price
- $56.4
- Updated
- 2024/03/01
- Product number
- B25698
- Product name
- 3-Chloropropionyl chloride, 97%
- Packaging
- 100g
- Price
- $78.8
- Updated
- 2024/03/01
- Product number
- C380600
- Product name
- 3-Chloropropionyl chloride
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC71810
- Product name
- 3-Chloropropionyl chloride
- Packaging
- 50g
- Price
- $50
- Updated
- 2021/12/16
3-Chloropropionyl chloride Chemical Properties,Usage,Production
Description
3-Chloropropionyl chloride is an important bifunctional reagent. It is capable of acylation and possesses a 2-chloro-ethyl fragment (CH2CH2Cl), which can be subjected to nucleophilic substitution and serves as a masked vinyl group. It can be used as a starting material in many reactions to construct a variety of (hetero)cyclic compounds.
Chemical Properties
Clear colorless to dark brown liquid. Soluble in ethanol, ether and chloroform. Slightly soluble in water.
Uses
3-Chloropropionyl chloride is a reagent used in the synthesis of Beclamide (B119400), which is a chlorinated benzylpropanamide used as an anticonvulsant drug. It is used in the treatment of tonic-clonic seizyres and has sedative properties.
Preparation
3-Chloropropionyl chloride (1) is commercially available and can be prepared from β-propiolactone (2) and thionyl chloride.1 Other standard methods available for the preparation of acyl chlorides can also be applied: the reaction of acrylic acid (3) or 3-chloropropionic acid (4) with thionyl chloride, phosphoryl chloride, phosgene, or phosphorus trichloride.
Reactions
(1) The Friedel¨CCrafts acylation of tert-butylbenzene (5) with 3-chloropropionyl chloride (1) followed by cyclization provid- ed indanone 6, which was further transformed into urea derivative 7, a potent TRPV1 antagonist.
(2) A novel high-yielding one-pot microwave-assisted synthesis of condensed 5-substituted pyranoisoquinoline-1,6-diones 9 from 2-substituted isoquinoline-1,3-diones 8 and 3-chloropropionyl chloride (1) was reported.
(3) Acylation of 2-aminophenol (12) with 3-chloropropionyl chloride (1), followed by cyclization in the presence of polyphosphoric acid (PPA), gave benzoxazole 13, which was further reacted with 4-chlorophenyl-1-piperazine to yield the target benzo[d]oxazole analogue 14, a selective dopamine D4 receptor ligand.
Flammability and Explosibility
Non flammable
Synthesis
3-Chloropropionyl chloride is produced by reaction of acrylic acid with hydrogen chloride and phosgene in the presence of, for example,dimethylformamide as catalyst, or by reaction of propiolactone with thionyl chloride.
Synthesis
3-Chloropropionyl chloride is produced by reaction of acrylic acid with hydrogen chloride and phosgene in the presence of, for example, dimethylformamide as catalyst, or by reaction of propiolactone with thionyl chloride.
3-Chloropropionyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Chloropropionyl chloride manufacturers
- Product
- 3-Chloropropionyl chloride 625-36-5
- Price
- US $8.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-22
- Product
- 3-Chloropropionyl Chloride 625-36-5
- Price
- US $140.00/Kg
- Min. Order
- 1Kg
- Purity
- 99 %
- Supply Ability
- 500 Kg
- Release date
- 2024-03-02
- Product
- Allylbenzene 625-36-5
- Price
- US $9.10/KG
- Min. Order
- 1KG
- Purity
- 99.%
- Supply Ability
- 10 ton
- Release date
- 2021-08-18