D-(-)-PANTOLACTONE

Product Name: D-(-)-PANTOLACTONE
CAS No.: 599-04-2
Chemical Name: D-(-)-PANTOLACTONE
Synonyms: PANTOLACTONE;D-PANTOLACTONE;(R)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one;Pantoyl lactone;Pantoyllactone;(R)-(-)-PANTOLACTONE;Dexpanthenol Lactone IMpurity;(3R)-3-hydroxy-4,4-dimethyloxolan-2-one;2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (R)-;Pantolacton
CBNumber: CB3748921
Molecular Formula: C6H10O3
Formula Weight: 130.14
MOL File: 599-04-2.mol

More

Less

D-(-)-PANTOLACTONE Property

Melting point:: 91 °C(lit.)
Boiling point:: 120-122 °C15 mm Hg(lit.)
Density: 1.1066 (rough estimate)
vapor pressure: 0.3-3.28Pa at 15-35℃
refractive index: -50.8 ° (C=2, H2O)
Flash point:: 120-122°C/15mm
storage temp.: 2-8°C
solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Sparingly)
pka: 13.12±0.40(Predicted)
form: Crystals or Crystalline Powder
color: White
Odor: cotton candy
optical activity: [α]25/D 49.8°, c = 2 in H2O
Water Solubility: almost transparency
Sensitive: Hygroscopic
Merck: 14,7013
BRN: 80957
InChIKey: SERHXTVXHNVDKA-BYPYZUCNSA-N
LogP: -0.973--0.46 at 22.5-25℃ and pH7.1
CAS DataBase Reference: 599-04-2(CAS DataBase Reference)
EPA Substance Registry System: Pantolactone (599-04-2)

More

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 1
F: 3-10
TSCA: Yes
HS Code: 29322090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 237817
Product name: D-(?)-Pantolactone
Purity: 99%
Packaging: 5g
Price: $19.98
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1494807
Product name: Pantolactone
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $1310
Updated: 2024/03/01

TCI Chemical

Product number: P0011
Product name: D-(-)-Pantolactone
Purity: >98.0%(T)
Packaging: 25g
Price: $52
Updated: 2021/12/16

TCI Chemical

Product number: P0011
Product name: D-(-)-Pantolactone
Purity: >98.0%(T)
Packaging: 500g
Price: $469
Updated: 2022/04/27

Alfa Aesar

Product number: L15983
Product name: D-(-)-Pantolactone, 99%
Packaging: 5g
Price: $23.65
Updated: 2024/03/01

More

Less

D-(-)-PANTOLACTONE Chemical Properties,Usage,Production

Chemical Properties

WHITE CRYSTALLINE POWDER OR CRYSTALS

Uses

D-(-)-Pantolactone is a chiral auxiliary used in many asymmetric synthesis reactions.
It can be used as a chiral starting material to synthesize:

An insect sex pheromone named 1S,2S,3R-1-acetoxymethyl-2,3,4,4-tetrameth-ylcyclopentane.
(-)-Enantiomer of (R)-8-hydroxy-4,7,7-trimethyl-7,8-dihydrocyclopenta[e]isoindole-1,3(2H,6H)-dione, a norsesquiterpene alkaloid.
A bicyclic diterpene named isofregenedadiol.

Uses

D-(-)-PANTOLACTONE is an important intermediate in the synthesis of pantothenic acid as well as a degradation product of pantothneic acid in the liver. Causes disorientation and hypothermia, and prevents phenamine-induced hyperthermia.

Definition

ChEBI: (R)-pantolactone is a butan-4-olide that is dihydrofuran-2(3H)-one substituted by a hydroxy group at position 3 and two methyl groups at position 4 (the R-stereoisomer). It has a role as a Saccharomyces cerevisiae metabolite. It is functionally related to a (R)-pantoic acid.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Purification Methods

Recrystallise the lactone from Et2O/pet ether, diisopropyl ether or *C6H6/pet ether and sublime it at 25o/0.0001mm. It hydrolyses readily to the hydroxy-acid and racemises when heated above 145o. The Brucine salt has m 211-212o (from EtOH). [Kuhn & Wieland Chem Ber 73 1134 1940, and Stiller et al. J Am Chem Soc 62 1779 1940, Bental & Tishler J Am Chem Soc 68 1463 1946, Beilstein 18/1 V 22.]

D-(-)-PANTOLACTONE Preparation Products And Raw materials

Raw materials

Formaldehyde Sodium cyanide HYDROGEN CYANIDE Methanol Isobutyraldehyde Sulfuric acid

Preparation Products

More

Less

D-(-)-PANTOLACTONE Suppliers

Americas 1 Belgium 3 Canada 2 China 238 Europe 3 France 1 Germany 5 India 8 Japan 4 Poland 1 Switzerland 2 The Netherlands 2 Ukraine 1 United Kingdom 12 United States 42 Global 325

HuBei ShengBaoLai Biological Technology Co., Ltd

Tel: 027-027-59105235 13007105135
Fax: 027-59105235
Email: sbl1120@163.com
Country: China
ProdList: 107
Advantage: 55

Shanghai Linchen Pharmaceutical Technology co.,LTD

Tel: 021-31606595 13761181955
Email: info@linchenpharm.com
Country: China
ProdList: 147
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2210
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11660
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696;
Email: info@hanhongsci.com
Country: China
ProdList: 42982
Advantage: 64

More

Less

View Lastest Price from D-(-)-PANTOLACTONE manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: D-(-)-PANTOLACTONE 599-04-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2023-09-13

XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD

Product: D-(-)-PANTOLACTONE 599-04-2
Price: US $25.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 5000KG/MONTH
Release date: 2022-01-20

Hebei Guanlang Biotechnology Co,.LTD

Product: D-(-)-Pantolactone 599-04-2
Price: US $15.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 1 ton
Release date: 2021-06-23

599-04-2, D-(-)-PANTOLACTONERelated Search:

H-BETA-ALA-BETA-ALA-OH (2S)-2,4-Dihydroxy-3,3-dimethylbutanoic acid (R)-Methyl 3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate Vitamin B5 Impurity 1 3,3-BIS(N,N-DIPROPANOIC ACID) DL-Pantolactone PICROTOXIN L-Pantolactone, (S)-(+)-β,β-Dimethyl-α-hydroxy-γ-butyrolactone,(S)-(+)-PANTOLACTONE,L-PANTOLACTONE ALPHA-HYDROXY-GAMMA-BUTYROLACTONE Bilobalide GINKGOLIDEM Ginkgolide A Ginkgolide J PICROTOXININ Ginkgolide B Ginkgolide C PICROTIN Gamma Butyrolactone

(R)-()-β,β-Dimethyl-α-hydroxy-γ-butyrolactone

(R)-(-)-DIHYDRO-3-HYDROXY-4,4-DIMETHYL-2(3H)-FURANONE

(R)-DIHYDRO-3-HYDROXY-4,4-DIMETHYL-2(3H)-FURANONE

(R)-(-)-BETA,BETA-DIMETHYL-ALPHA-HYDROXY-GAMMA-BUTYROLACTONE

(R)-(-)-PANTOLACTONE

(R)-(-)-ALPHA-HYDROXY-BETA,BETA-DIMETHYL-GAMMA-BUTYROLACTONE

R(-)-3,3-DIMETHYL-2-HYDROXY-GAMMA-BUTYROLACTONE

R(-)-2-HYDROXY-3,3-DIMETHYL-GAMMA-BUTYROLACTONE

PANTOIC ACID GAMMA-LACTONE

PANTOLACTONE

PANTOLACTONE-D

2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (R)-

2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, D-(-)-

4-dimethyl-dihydro-3-hydroxy-(theta)-2(3h)-furanon

D-(-)-Pantoic acid lactone

D-(-)-Pantolyl lactone

dihydro-3-hydroxy-4,4-dimethyl-,(R)-2(3H)-Furanone

Dihydro-4,4-dimethyl-3-hydroxy-2(3H)-furanone

-Hydroxy-,-dimethyl-butyrolactone

Pantoiclactone

Pantolyl lactone

Pantothenic lactone

Pantoyl lactone

Pantoyllactone

Pentoyl lactone

Pentoyl lactone clene

D-()-Pantolactone,(R)-()-α-Hydroxy-β,β-dimethyl-γ-butyrolactone, (R)-()-β,β-Dimethyl-α-hydroxy-γ-butyrolactone, (R)-()-Pantolactone, Pantoic acid γ-lactone

Pan-acid lactone

(-)-2-Hydroxy-3,3-diMethyl-γ-butyrolactone

(3R)-Dihydro-3-hydroxy-4,4-diMethyl-2(3H)-furanone

(3R)-Tetrahydro-3-hydroxy-4,4-diMethylfuran-2-one

(R)-(-)-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone D-(-)-2-Hydroxy-3,3-dimethyl-gamma-butyrolactone D-(-)-Pantoyl Lactone

Dexpanthenol Lactone IMpurity

Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone

D-(-)-Pantolactone 99%

(R)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one

(R)-Pantolacton

Dexpanthenol Impurity 1

(3R)-3-hydroxy-4,4-dimethyloxolan-2-one

2,4-DIHYDROXY-3,3-DIMETHYLBUTYRIC ACID GAMMA-LACTONE

ALPHA-HYDROXY-BETA,BETA-DIMETHYL-GAMMA-BUTYROLACTONE

D-(-)-PANTOYL LACTONE

D-PANTOYL LACTONE

D-PANTOIC ACID G-LACTONE

(-)-D-PANTOLACTONE

D-(-)-PANTOLACTONE

D-PANTOLACTONE

D-ALPHA-HYDROXY-BETA,BETA-DIMETHYL-GAMMA-BUTYROLACTONE

D-1-HYDROXY-2,2-DIMETHYL-3-BUTYROLACTONE

D-(-)-2-HYDROXY-3,3-DIMETHYL-GAMMA-BUTYROLACTONE

D-(-)-DIHYDRO-3-HYDROXY-4,4-DIMETHYL-2(3H)-FURANONE

(R)-N-Pantolactone

(R)-Pantoyl lactone

alpha-Hydroxy-beta,beta-dimethyl-alpha-butyrolactone

D-MINUS-PANTOYLLACTONE

D-(-)-PANTOYL LACTONE 98+%

D-(-)-Pantanolactone

D-(-)-Pantolactone,99%