Bilobalide
- Product Name
- Bilobalide
- CAS No.
- 33570-04-6
- Chemical Name
- Bilobalide
- Synonyms
- BILOBALID;BILOBALIDE;VITEXICARPIM;Bilobalide A;Ginkgolactone;(-)-BILOBALIDE;BILOBALIDE(SH);Bilobalide >BILOBALIDE(AHP);Bilobalide USP/EP/BP
- CBNumber
- CB1688713
- Molecular Formula
- C15H18O8
- Formula Weight
- 326.3
- MOL File
- 33570-04-6.mol
Bilobalide Property
- Melting point:
- >300°
- alpha
- 57820 -64.3° (c = 2 in acetone)
- Boiling point:
- 651.7±55.0 °C(Predicted)
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Acetone (Slightly), Methanol (Slightly)
- pka
- 11.74±0.40(Predicted)
- color
- White to Off-White
- Merck
- 14,1220
- Stability:
- Hygroscopic
- LogP
- -0.450 (est)
- CAS DataBase Reference
- 33570-04-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B9031
- Product name
- (?)-Bilobalide from Ginkgo biloba leaves
- Purity
- ≥93% (HPLC)
- Packaging
- 10mg
- Price
- $89.6
- Updated
- 2024/03/01
- Product number
- PHL89167
- Product name
- (-)-Bilobalide
- Purity
- phyproof? Reference Substance
- Packaging
- 10MG
- Price
- $430
- Updated
- 2024/03/01
- Product number
- 79593
- Product name
- (?)-Bilobalide
- Purity
- analytical standard
- Packaging
- 10mg
- Price
- $405
- Updated
- 2024/03/01
- Product number
- 00760595
- Product name
- Bilobalide
- Purity
- primary reference standard
- Packaging
- 10mg
- Price
- $471
- Updated
- 2023/01/07
- Product number
- B4388
- Product name
- Bilobalide
- Purity
- >95.0%(GC)
- Packaging
- 10mg
- Price
- $143
- Updated
- 2024/03/01
Bilobalide Chemical Properties,Usage,Production
Description
Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba. It has been shown to protect against cerebral edema, decrease cortical infarct volume, and reduce cerebral ischemic damage. Bilobalide, at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions. It also activates the rat constitutive androstane receptor at 100 μM and increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes.
Uses
Reference Standard in the analysis of herbal medicinal products
Uses
Bilobalide provides protection against learning and memory impairment by reducing free radical injury and inhibiting neuronal apoptosis in the brain cortex and hippocampal CA1 region in induced vascular dementia rats.
Definition
ChEBI: A terpenoid trilactone found in extracts of Ginkgo biloba.
General Description
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.
Enzyme inhibitor
This plant natural product (FW = 326.30 g/mol; CAS 33570-04-6) from the gingko tree (Ginkgo biloba) is a terpene trilactone that exhibits anticonvulsant properties. Bilobalide has multiple mechanisms of action (e.g., acting as a GABAA receptor antagonist (/1), preserving mitochondrial ATP synthesis, inhibiting staurosporine-induced apoptotic damage, suppressing hypoxia-induced membrane deterioration in the brain, and increasing the expression the mitochondrial DNA-encoded COX III subunit of cytochrome c oxidase and the ND1 subunit of NADH dehydrogenase). Bilobalide was later synthesized in E. J. Corey’s laboratory in the late 1980s.
Bilobalide Preparation Products And Raw materials
Raw materials
Preparation Products
Bilobalide Suppliers
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View Lastest Price from Bilobalide manufacturers
- Product
- 2,4,6-Trihydroxybenzoic acid 33570-04-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000ton
- Release date
- 2023-08-21
- Product
- Bilobalide 33570-04-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000ton
- Release date
- 2023-12-05
- Product
- Bilobalide 33570-04-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 50000kg
- Release date
- 2023-08-03