Bilobalide

ChemicalBook > CAS DataBase List > Bilobalide

Product Name: Bilobalide
CAS No.: 33570-04-6
Chemical Name: Bilobalide
Synonyms: BILOBALID;BILOBALIDE;VITEXICARPIM;Bilobalide A;Ginkgolactone;(-)-BILOBALIDE;BILOBALIDE(SH);Bilobalide >BILOBALIDE(AHP);Bilobalide USP/EP/BP
CBNumber: CB1688713
Molecular Formula: C15H18O8
Formula Weight: 326.3
MOL File: 33570-04-6.mol

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Bilobalide Property

Melting point:: >300°
alpha: 57820 -64.3° (c = 2 in acetone)
Boiling point:: 651.7±55.0 °C(Predicted)
Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: Acetone (Slightly), Methanol (Slightly)
pka: 11.74±0.40(Predicted)
color: White to Off-White
Merck: 14,1220
Stability:: Hygroscopic
LogP: -0.450 (est)
CAS DataBase Reference: 33570-04-6(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
RTECS: LV1665000
F: 10
HS Code: 29322090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B9031
Product name: (?)-Bilobalide from Ginkgo biloba leaves
Purity: ≥93% (HPLC)
Packaging: 10mg
Price: $89.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL89167
Product name: (-)-Bilobalide
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $430
Updated: 2024/03/01

Sigma-Aldrich

Product number: 79593
Product name: (?)-Bilobalide
Purity: analytical standard
Packaging: 10mg
Price: $405
Updated: 2024/03/01

Sigma-Aldrich

Product number: 00760595
Product name: Bilobalide
Purity: primary reference standard
Packaging: 10mg
Price: $471
Updated: 2023/01/07

TCI Chemical

Product number: B4388
Product name: Bilobalide
Purity: >95.0%(GC)
Packaging: 10mg
Price: $143
Updated: 2024/03/01

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Bilobalide Chemical Properties,Usage,Production

Description

Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba. It has been shown to protect against cerebral edema, decrease cortical infarct volume, and reduce cerebral ischemic damage. Bilobalide, at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions. It also activates the rat constitutive androstane receptor at 100 μM and increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes.

Uses

Reference Standard in the analysis of herbal medicinal products

Uses

Bilobalide provides protection against learning and memory impairment by reducing free radical injury and inhibiting neuronal apoptosis in the brain cortex and hippocampal CA1 region in induced vascular dementia rats.

Definition

ChEBI: A terpenoid trilactone found in extracts of Ginkgo biloba.

General Description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Enzyme inhibitor

This plant natural product (FW = 326.30 g/mol; CAS 33570-04-6) from the gingko tree (Ginkgo biloba) is a terpene trilactone that exhibits anticonvulsant properties. Bilobalide has multiple mechanisms of action (e.g., acting as a GABAA receptor antagonist (/1), preserving mitochondrial ATP synthesis, inhibiting staurosporine-induced apoptotic damage, suppressing hypoxia-induced membrane deterioration in the brain, and increasing the expression the mitochondrial DNA-encoded COX III subunit of cytochrome c oxidase and the ND1 subunit of NADH dehydrogenase). Bilobalide was later synthesized in E. J. Corey’s laboratory in the late 1980s.

Bilobalide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Bilobalide manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: 2,4,6-Trihydroxybenzoic acid 33570-04-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000ton
Release date: 2023-08-21

Shaanxi Haibo Biotechnology Co., Ltd

Product: Bilobalide 33570-04-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000ton
Release date: 2023-12-05

Hebei Kingfiner Technology Development Co.Ltd

Product: Bilobalide 33570-04-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 50000kg
Release date: 2023-08-03

33570-04-6, BilobalideRelated Search:

2,2-Dimethylglutaric acid Ethylidene diacetate ALPHA,ALPHA-DIMETHYL-GAMMA-BUTYROLACTONE Whiskey lactone Bilobalide 3-ETHYL-3-METHYLGLUTARIC ACID D-(-)-PANTOLACTONE (+)-3-METHYLHEXANEDIOIC ACID (TETRAHYDRO-FURAN-3-YL)-ACETIC ACID TETRAHYDRO-3-FUROIC ACID METHYL TUBERATE 3,3-Dimethylglutaric acid DL-LEUCIC ACID DL-Pantolactone Azelaic acid 3-Methyladipic acid (+)-METHYL (S)-3-HYDROXYPENTANOATE 2,2-Dimethylsuccinic acid

BILOBALID

4H,5aH,9H-Furo[2,3-b]furo[3',2':2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione, 9-(1,1-dimethylethyl)-10,10a-dihydro-8,9-dihydroxy-, (3aS,5aR,8R,8aS,9R,10aS)-

(5AR- (3AS*,5AΑ,8B,8AS*,9A,10AΑ))- 9-(1,1-DIMETHYLETHYL)- 10,10A-DIHYDRO- 8,9-DIHYDROXY- 4H,5AH,9H-FURO[2,3-B]FURO[3',2':2,3]CYCLOPENTA[1,2-C]FURAN- 2,4,7(3H,8H)-TRIONE

(-)-Bilobalide, 98%, from Ginkgo biloba L.

Bilobalide 33570-04-6

(-)-BILOBALIDE

BILOBALIDE

5,3'-DIHYDROXY-3,6,7,4'-TETRAMETHOXYFLAVONE

4H,5AH,9H-FURO[2,3-B]FURO[3',2':2,3]CYCLOPENTA[1,2-C]FURAN-2,4,7(3H,8H)-TRIONE,9-(1,1-DIMETHYLETHYL)-10,10A-DIHYDRO-8,9-DIHYDROXY-, [5AR-(3AS*,5A,8,8AS*,9,10A)]-

3',5-DIHYDROXY-3,4',6,7-TETRAMETHOXY FLAVONE

VITEXICARPIM

BILOBALIDE(SH)

4H,5aH,9H-Furo[2,3-b]furo[3',2':2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione,9-(1,1-dimethylethyl)-10,10a-dihydro-8,9-dihydroxy-,[5aR-(3aS*,5aα,8β,8aS*,9α,10aα)]-

(-)-bilobalidefromginkgoleaves

BILOBALIDE: 4H,5AH,9H-FURO[2,3-B]FURO[3',2':2,3]CYCLOPENTA[1,2-C]FURAN-2,4,7(3H,8H)-TRIONE,9-(1,1-DIMETHYLETHYL)-10,10A-DIHYDRO-8,9-DIHYDROXY-, [5AR-(3AS*,5A,8,8AS*,9,10A)]-,

(-)-bilobalide from ginkgo biloba leaves

BILOBALIDE(AHP)

Bilobalide A

(-)-Bilobalide, froM Ginkgo biloba

Bilobalide &gt

Bilobalide USP/EP/BP

(-)-Bilobalide from Ginkgo biloba leaves

(-)-bilobalide from ginkgo leaves

-Amino-2-methyl-40H-tetrazole

Ginkgolactone

(?)-Bilobalide from Ginkgo biloba leaves

33570-04-6

C15H18O9

C15H18O8

Inhibitors

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Heterocycles

Biochemicals Found in Plants

Isoprenoid/terpenoid

Nutrition Research