PICROTIN
- Product Name
- PICROTIN
- CAS No.
- 21416-53-5
- Chemical Name
- PICROTIN
- Synonyms
- PICROTIN;Picrotin CRS;(1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-Hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione;3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-;(1aR,8aS,9S)-1aβ,2,2a,6,6aα,8b-Hexahydro-2aα-hydroxy-9-(1-hydroxy-1-methylethyl)-8bα-methyl-3α,6α-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione
- CBNumber
- CB2383778
- Molecular Formula
- C15H18O7
- Formula Weight
- 310.3
- MOL File
- 21416-53-5.mol
PICROTIN Property
- Melting point:
- 256-258°C
- alpha
- D -64.7° (c = 2.31 in abs alc)
- Boiling point:
- 595.8±50.0 °C(Predicted)
- Density
- 1.59
- storage temp.
- 2-8°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml
- pka
- 13.28±0.60(Predicted)
- EPA Substance Registry System
- Picrotin (21416-53-5)
Safety
- WGK Germany
- 3
- RTECS
- TJ8800000
- Toxicity
- LD50 i.p. in mice: 135 mg/kg (Jarboe)
N-Bromosuccinimide Price
- Product number
- Y0001508
- Product name
- Picrotin
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001508
- Price
- $220
- Updated
- 2024/03/01
- Product number
- 21870
- Product name
- Picrotin
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21870
- Product name
- Picrotin
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 21870
- Product name
- Picrotin
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $98
- Updated
- 2024/03/01
- Product number
- 21870
- Product name
- Picrotin
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $169
- Updated
- 2024/03/01
PICROTIN Chemical Properties,Usage,Production
Description
Picrotin is a natural picrotoxane that antagonizes glycine receptors (GlyRs; IC50s = 57 and 117 μM for α1 and α2 homodimeric GlyRs, respectively). It also inhibits α3 homodimeric GlyRs. Picrotin is inactive in inhibiting γ-aminobutyric acid (GABA) type A and type C receptors. Picrotin occurs in the natural plant-derived poison picrotoxin , equimolar with picrotoxinin.
Uses
GABAa receptor antagonist
Definition
ChEBI: Picrotin is an organic heteropentacyclic compound that is picrotoxinin in which the olefinic double bond has undergone addition of water to give the corresponding tertiary alcohol. It is the less toxic component of picrotoxin, lacking GABA activity. It has a role as a plant metabolite. It is an organic heteropentacyclic compound, an epoxide, a tertiary alcohol, a gamma-lactone, a diol and a picrotoxane sesquiterpenoid. It is functionally related to a picrotoxinin.