Spirapril

Product Name: Spirapril
CAS No.: 83647-97-6
Chemical Name: Spirapril
Synonyms: SPIRAPRIL;Sandopfil;Sch-33844;Espirapril;Brn 4277924;Spiraprilum;Spiraprilic acid;Spiraprilum [latin];Spirapril [inn:ban];Spirapril USP/EP/BP
CBNumber: CB5285875
Molecular Formula: C22H30N2O5S2
Formula Weight: 466.61
MOL File: 83647-97-6.mol

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Spirapril Property

Boiling point:: 697.8±55.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 2.99±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0004227
Product name: SPIRAPRIL
Purity: 95.00%
Packaging: 100MG
Price: $624.57
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0004227
Product name: SPIRAPRIL
Purity: 95.00%
Packaging: 250MG
Price: $697.34
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0004227
Product name: SPIRAPRIL
Purity: 95.00%
Packaging: 1G
Price: $1904.7
Updated: 2021/12/16

AHH

Product number: MT-58707
Product name: Spirapril
Purity: 98%
Packaging: 5g
Price: $830
Updated: 2021/12/16

Chemenu

Product number: CM139337
Product name: (S)-7-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylicacid
Purity: 95%
Packaging: 1g
Price: $1122
Updated: 2021/12/16

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Spirapril Chemical Properties,Usage,Production

Chemical Properties

Hemihydrate: white foamy substance. [α]D26-29.5° (C=0.2, ethanol). Spirapril Hydrochloride (Spirapril Hydrochloride): C22 H3ON2O5S2?HCl.[94841-17-5]. White solid, melting point 192-194°C (decomposition). [α]D26-11.2° (C=0.4, ethanol). Spiraprilat (Spiraprilat): C20H26N2O5S2.[83602-05-5]. Diacid for spirapril. Semihydrate, melting point 163～165°C. [α]D26+4.1° (C=0.4, ethanol).

Uses

Spirapril is an Angiotensin-converting enzyme inhibitor and used to treat high blood pressure.

Definition

ChEBI: Spirapril is a dipeptide, a dithioketal, an azaspiro compound, a dicarboxylic acid monoester, an ethyl ester, a tertiary carboxamide, a secondary amino compound and a pyrrolidinecarboxylic acid. It has a role as a prodrug, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and an antihypertensive agent. It is functionally related to a spiraprilat.

in vivo

Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice^[2].
Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice^[2].
Spirapril can crosses the blood-brain barrier and suppresses the transgene effect in the experiments^[2].
Spirapril prevents left ventricular hypertrophy, decreases myocardial damage and promotes angiogenesis in spontaneously hypertensive rats^[3].

Spirapril Preparation Products And Raw materials

Raw materials

p-Toluenesulfonic acid Ethyl 2-oxo-4-phenylbutyrate 1,2-Ethanedithiol

Preparation Products

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Spirapril Suppliers

Canada 1 China 22 Europe 2 Germany 1 India 1 United Kingdom 4 United States 8 USA 1 Global 40

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 8025
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

SIMAGCHEM CORP

Tel: +86-5922680277 +86-13806087780
Email: sale@simagchem.com
Country: China
ProdList: 17346
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Wuhan pengyin Pharmaceutical Co., Ltd

Tel: 13163333255
Email: 1939328613@qq.com
Country: China
ProdList: 395
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Sinoway Industrial co., ltd.

Tel: +86-0592-5800732 +86-13806035118
Fax: 0592-5854960
Email: xie@china-sinoway.com
Country: China
ProdList: 1275
Advantage: 58

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View Lastest Price from Spirapril manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Spirapril 83647-97-6
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-09

83647-97-6, SpiraprilRelated Search:

Betaine Glycine Lisinopril ALTRENOGEST Enalapril maleate Ramipril 3,4'-DIAMINODIPHENYLMETHANE Lithium diisopropylamide Enalapril 1,1'-Carbonyldiimidazole Carbonyl iron powder NICKEL CARBONYL L-ETHIONINE L-Homophenylalanine ethyl ester hydrochloride 2,2'-(ETHYLENEDIIMINO)-DIBUTYRIC ACID Enalapril Maleate Tablets Spirapril hydrochloride N-Acetyl-DL-ethionine

(8S-(7(R*(R*)),8R*))-7-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid

SPIRAPRIL

SPIRAPRIL FOR SYSTEM SUITABILITY EPY

SPIRAPRIL FOR SYSTEM SUITABILITY EPY(CRM STANDARD)

1,4-Dithia-7-azaspiro(4,4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, (8S-(7(R*(R*)),8R*))-

Brn 4277924

Espirapril

Espirapril [spanish]

Spirapril [inn:ban]

Spiraprilum

Spiraprilum [latin]

Sandopfil

Sch-33844

Spiraprilic acid

Spirapril USP/EP/BP

1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, 7-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-, (8S)-

83647-97-6

C22H30N2O5S2