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Enalapril

Product Name
Enalapril
CAS No.
75847-73-3
Chemical Name
Enalapril
Synonyms
Vasotec;Renitec;G1ioten;Hipoartd;ENALAPRIL;Enalapril hydrate;Enalapril (MK-421);ELAPRILAT DIHYDRAT;Enalapril USP/EP/BP;Enalapril AldrichCPR
CBNumber
CB1295108
Molecular Formula
C20H28N2O5
Formula Weight
376.45
MOL File
75847-73-3.mol
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Enalapril Property

Melting point:
142-147℃
Boiling point:
582.4±50.0 °C(Predicted)
Density 
1.204±0.06 g/cm3(Predicted)
RTECS 
TW3665500
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in DMSO
form 
Powder
pka
pKa 2.97 (H2O t=25.0)(Approximate);5.35(H2O t=25.0)(Approximate)
color 
White to off-white
optical activity
-58.8066°(C=0.7659g/100ml DMF)
Water Solubility 
Soluble in water at 25mg/ml
BCS Class
3
InChIKey
GBXSMTUPTTWBMN-XIRDDKMYSA-N
SMILES
C(O)(=O)[C@@H]1CCCN1C(=O)[C@H](C)N[C@H](C(OCC)=O)CCC1=CC=CC=C1
CAS DataBase Reference
75847-73-3(CAS DataBase Reference)
EPA Substance Registry System
L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl- (75847-73-3)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
Hazardous Substances Data
75847-73-3(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16041
Product name
Enalapril
Purity
≥98%
Packaging
5g
Price
$165
Updated
2021/12/16
Cayman Chemical
Product number
16041
Product name
Enalapril
Purity
≥98%
Packaging
1g
Price
$48
Updated
2021/12/16
Cayman Chemical
Product number
16041
Product name
Enalapril
Purity
≥98%
Packaging
10g
Price
$270
Updated
2021/12/16
Cayman Chemical
Product number
16041
Product name
Enalapril
Purity
≥98%
Packaging
500mg
Price
$30
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
D33952
Product name
Enalapril-d5Maleate
Packaging
5mg
Price
$1500
Updated
2021/12/16
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Enalapril Chemical Properties,Usage,Production

Uses

It is used for hypertension and chronic cardiac insufficiency.

Uses

Enalapril is used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. It has been proven to protect the function of the kidneys in hypertension, heart failure, and diabetes, and may be used in the absence of hypertension for its kidney protective effects. It is widely used in chronic kidney failure.

Uses

angiotensin converting enzyme inhibitor

Definition

ChEBI: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).

Mechanism of action

Like captopril, enalapril selectively suppresses the rennin–angiotensin–aldosterone system, inhibits angiotensin-converting enzyme, and prevents conversion of angiotensin I into angiotensin II.

Synthesis

Enalapril, (S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline (22.7.12), is synthesized by reacting the benzyl ester of L-alanyl-L-proline with the ethyl ester of 3-benzoylacrylic acid, which forms the product 22.7.11, the reduction of which with hydrogen using a Raney nickel catalyst removes the protective benzyl group, giving the desired enalapril (22.7.12) [24]. Alternative methods of syntheses have also been proposed.

in vivo

Enalapril (intraperitoneal injection, 0.03 mg/kg, once, 1 hour) reduces infarct volume due to middle cerebral artery occlusion and lower or higher doses are ineffective in Male NMRI mice[4].

Animal Model:Male NMRI mice 20-40 g[4]
Dosage:0.03 mg/kg
Administration:Intraperitoneal injection; once
Result:Reduced the area of middle cerebral artery infarction in mice at 0.03 mg/kg.

Enalapril Preparation Products And Raw materials

Raw materials

N-Hydroxysuccinimide Enalapril maleate Palladium carbon fine chemical catalyzer Benzyl ester Ethyl 2-oxo-4-phenylbutyrate Maleic acid Maleic anhydride PROPYLENE dipeptide L-Alanyl-L-proline Water L-Proline Bromobenzene Concentrated sulfuric acid Benzene Ethyl acetate D-Alanine Acetic acid Ethyl acrylate DOWEX(R) 50WX4 HYDROGEN FORM Sodium cyanoborohydride Dicyclohexylcarbodiimide Formamide

Preparation Products

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Enalapril Suppliers

Bangladesh 1 Belgium 1 Brazil 1 Canada 2 China 131 Europe 1 France 2 Germany 7 India 16 South Korea 2 Switzerland 1 The Netherlands 1 United Kingdom 11 United States 33 Global 210
Indis NV
Tel
--
Fax
--
Email
info@indis.be
Country
Belgium
ProdList
465
Advantage
58
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View Lastest Price from Enalapril manufacturers

Sinoway Industrial co., ltd.
Product
Enalapril 75847-73-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-04-28
Zhuozhou Wenxi import and Export Co., Ltd
Product
Enalapril 75847-73-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Enalapril 75847-73-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

75847-73-3, EnalaprilRelated Search:

cis-4-Hydroxy-L-proline Ethyl acrylate L-PROLINE-(4-3H(N)) Ethylbenzene Ethylparaben D-Proline Tris(trimethylsilyl)phosphate Ethanol Ethyl acetate ENALAPRILAT-D5 ENALAPRILAT-D5, SODIUM SALT Trandolapril Indolapril N2-1[(1S)-Ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysyl-L-proline Spirapril Enalapril Maleate Tablets Enalapril maleate Enalapril-D5 tert-Butyl Ester

  • ENALAPRIL
  • (s)-1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-proline
  • 1-(n-((s)-1-carboxy-3-phenylpropyl)-l-alanyl)-l-proline 1'-ethyl ester
  • 1-[2-(1-ETHOXYCARBONYL-3-PHENYL-PROPYL)AMINOPROPANOYL]PYRROLIDINE-2-CARBOXYLIC ACID
  • N-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline
  • Renitec
  • Vasotec
  • Enalapril Maleate USP24
  • L-Proline, 1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-, (S)-
  • L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-
  • (-)-1-[N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
  • 1-[N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
  • N-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro-OH
  • N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro-OH
  • (S)-1-((S)-2-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)aMino)propanoyl)pyrrolidine-2-carboxylic acid
  • Enalapril AldrichCPR
  • (S)-1-[N-[1-(Ethoxyearbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
  • G1ioten
  • Hipoartd
  • (2S)-1-[(2S)-2-[[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid
  • (S)-N-[1-Ethoxycarbonyl)-3-phenylpropyl]-Ala-Pro
  • Enalapril hydrate
  • Enalapril USP/EP/BP
  • Enalaprilat dihydrat
  • EnalaprilQ: What is Enalapril Q: What is the CAS Number of Enalapril Q: What is the storage condition of Enalapril Q: What are the applications of Enalapril
  • Enalapril (MK-421)
  • ELAPRILAT DIHYDRAT
  • 75847-73-3
  • C20H28N2O5
  • Angiotensin