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4-Methylmorpholine

Product Name
4-Methylmorpholine
CAS No.
109-02-4
Chemical Name
4-Methylmorpholine
Synonyms
NMM;N-METHYLMORPHOLINE;Methylmorpholine;N-Methyl morphofine;1-Methylmorpholine;Morpholine,4-methyl-;AKOS 89985;Texacat NMM;Lupragen N105;N-Methylmorphol
CBNumber
CB1170931
Molecular Formula
C5H11NO
Formula Weight
101.15
MOL File
109-02-4.mol
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4-Methylmorpholine Property

Melting point:
−66 °C(lit.)
Boiling point:
115-116 °C750 mm Hg(lit.)
Density 
0.92 g/mL at 25 °C(lit.)
vapor density 
>1 (vs air)
vapor pressure 
18 mm Hg ( 20 °C)
refractive index 
n20/D 1.435(lit.)
Flash point:
75 °F
storage temp. 
Store below +30°C.
solubility 
Chloroform (Soluble), Ethyl Acetate, Methanol (Slightly)
form 
Liquid
pka
7.38(at 25℃)
color 
Clear
Specific Gravity
0.920 (20/4℃)
PH
10.6 (50g/l, H2O, 20℃)
explosive limit
2.1%(V)
Water Solubility 
>500 g/L (20 ºC)
Merck 
14,6277
BRN 
102719
Stability:
Volatile
InChIKey
SJRJJKPEHAURKC-UHFFFAOYSA-N
LogP
-0.32 at 25℃
CAS DataBase Reference
109-02-4(CAS DataBase Reference)
NIST Chemistry Reference
Morpholine, 4-methyl-(109-02-4)
EPA Substance Registry System
4-Methylmorpholine (109-02-4)
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Safety

Hazard Codes 
F,C
Risk Statements 
11-20/21/22-34-10-22
Safety Statements 
16-26-36/37/39-45-25
RIDADR 
UN 2535 3/PG 2
WGK Germany 
1
RTECS 
QE5775000
10-23
Autoignition Temperature
165 °C DIN 51794
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29349990
Toxicity
LD50 orally in Rabbit: 1960 mg/kg LD50 dermal Rabbit 1240 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.05894
Product name
4-Methylmorpholine
Purity
for synthesis
Packaging
5ml
Price
$25.1
Updated
2024/03/01
Sigma-Aldrich
Product number
8.05894
Product name
4-Methylmorpholine
Purity
for synthesis
Packaging
250ML
Price
$33.3
Updated
2024/03/01
Sigma-Aldrich
Product number
8.05894
Product name
4-Methylmorpholine
Purity
for synthesis
Packaging
1L
Price
$129
Updated
2024/03/01
Sigma-Aldrich
Product number
8.05894
Product name
4-Methylmorpholine
Purity
for synthesis
Packaging
2.5L
Price
$240
Updated
2024/03/01
Sigma-Aldrich
Product number
8.05894
Product name
4-Methylmorpholine
Purity
for synthesis
Packaging
25kg
Price
$913
Updated
2024/03/01
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4-Methylmorpholine Chemical Properties,Usage,Production

Chemical Properties

colorless and transparent liquid. with characteristic odor. soluble in organic solvents, miscible with water and ethanol.

Uses

4-Methylmorpholine is an excellent solvent, emulsifier, corrosion inhibitor, Catalyst in polyurethane foamsextraction solvent, stabilizing agent for chlorinated hydrocarbons, and also can be used as pesticide intermediates. 4-Methylmorpholine is widely used in the synthesis of pesticide compounds such as insecticide, fungicide, plant growth regulator, etc. It is also used in the synthesis of fine chemicals such as surfactant, lubricant coolant, metal antirust agent, fiber treatment agent, etc.

Preparation

4-Methylmorpholine preparation method is to slowly add formaldehyde in morpholine drop by drop, under stirring add formic acid reaction, automatic reflux, and release carbon dioxide. After adding formic acid, heating reflux 4 ~ 5h, cooling and adding sodium hydroxide immediately distillation, collect all the fraction before the boiling point of 99 ℃, and then add sodium hydroxide in the fraction to saturation, cooling the oil layer, drying, fractional distillation, to obtain N-methylmorpholine.

Synthesis Reference(s)

Tetrahedron Letters, 36, p. 4881, 1995 DOI: 10.1016/0040-4039(95)00875-D

General Description

4-Methylmorpholine is a water-white liquid with an ammonia-like odor. Less dense than water and insoluble in water. Flash point 75°F. May be moderately toxic by ingestion, inhalation and skin absorption. Very irritating to skin, eyes, and mucous membranes. Used as a solvent and to make pharmaceuticals.

Air & Water Reactions

Highly flammable. Insoluble in water.

Reactivity Profile

Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Flammable

Purification Methods

Dry it by refluxing with BaO or sodium, then fractionally distil it through a helices-packed column. The picrate has m 227o, the thiocyanate salt has m 103o (from butanone). [Hall J Phys Chem 60 63 1956, Beilstein 27 I 203, 27 III/IV 22.]

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4-Methylmorpholine Suppliers

SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.
Tel
021-69106960 13701823733
Fax
021-69106780
Email
13701823733@163.com
Country
China
ProdList
4767
Advantage
60
Jiangsu lianrun chemical co. LTD
Tel
0517-85322222 17625179812
Email
sales@lianrunchem.com
Country
China
ProdList
8
Advantage
58
Sichuan Hongpeng New Materials Co., Ltd
Tel
13219866111
Email
13219866111@163.com
Country
China
ProdList
9
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Wohua Chemical Co., Ltd.
Tel
021-57681602-802 17302146015
Fax
57683062-808
Email
2851602437@qq.com
Country
China
ProdList
289
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
551-65418679 15837135945
Fax
0551-65418697
Email
info@tnjchem.com
Country
China
ProdList
1889
Advantage
62
Ningbo Hua Tuo Chemical Co., Ltd.
Tel
+86-0574-88237971 +86-15267895909
Fax
0574-88237323
Email
mia@sinotopchem.com
Country
China
ProdList
60
Advantage
58
Tianjinshi Haydn Science &Technology Development Co.,Ltd
Tel
022-88294560 13642153692
Email
313878807@qq.com
Country
China
ProdList
22
Advantage
58
Nanjing Haochuang Jiarong New Material Co., Ltd
Tel
133-57705004 13813022170
Email
591345372@qq.com
Country
China
ProdList
58
Advantage
58
Yixing Wencheng Chemical Co., Ltd
Tel
13961572207
Email
David@un-wencheng.com
Country
China
ProdList
131
Advantage
58
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View Lastest Price from 4-Methylmorpholine manufacturers

Yancheng Green Chemicals Co.,Ltd
Product
4-Methylmorpholine 109-02-4
Price
US $1.00/kg
Min. Order
1000kg
Purity
99
Supply Ability
10000
Release date
2022-12-13
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Methylmorpho line 109-02-4
Price
US $9.10/KG
Min. Order
1KG
Purity
99.%
Supply Ability
10000
Release date
2024-08-23
Hebei Weibang Biotechnology Co., Ltd
Product
4-Methylmorpholine 109-02-4
Price
US $25.00/KG
Min. Order
100ASSAYS
Purity
99.5%
Supply Ability
100 mt
Release date
2021-08-04

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