4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride

Product Name: 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride
CAS No.: 3945-69-5
Chemical Name: 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride
Synonyms: DMTMM;4-(4,6-DIMETHOXY-1,3,5-TRIAZIN-2-YL)-4-METHYLMORPHOLINIUM CHLORIDE;DMMTMM;DMTMM Cl;4-(4,6-Dime;4-(4,6-Dimethoxy-1,3;Rivaroxaban Impurity 235;KUNISHIMA COUPLING REAGENT;4-4-methylmorpholinium chloride;4,6-DIMETHOXY-1.3.5-TRIAZIN-2-YL
CBNumber: CB5695021
Molecular Formula: C10H19ClN4O4
Formula Weight: 294.74
MOL File: 3945-69-5.mol

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4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride Property

Melting point:: 110-114 °C
Flash point:: 92.5 °C
storage temp.: -20°C
solubility: DMSO (Slightly), Methanol (Sparingly), Water (Slightly)
form: Powder or Chunks
color: White
Water Solubility: Soluble in water, Methanol.
BRN: 8026872
Stability:: Hygroscopic
InChI: InChI=1S/C10H17N4O3.ClH.H2O/c1-14(4-6-17-7-5-14)8-11-9(15-2)13-10(12-8)16-3;;/h4-7H2,1-3H3;1H;1H2/q+1;;/p-1
InChIKey: BMTZEAOGFDXDAD-UHFFFAOYSA-M
SMILES: [N+]1(C)(CCOCC1)C1=NC(=NC(OC)=N1)OC.O.[Cl-]
CAS DataBase Reference: 3945-69-5(CAS DataBase Reference)

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Safety

Hazard Codes: C
Risk Statements: 22-34-40-20/21/22
Safety Statements: 26-36/37/39-45
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
F: 10-21
HazardClass: 8
PackingGroup: III
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 74104
Product name: 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride
Purity: ≥96.0% (calc. on dry substance, AT)
Packaging: 1g
Price: $98.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 74104
Product name: 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride
Purity: ≥96.0% (calc. on dry substance, AT)
Packaging: 5G
Price: $214
Updated: 2025/07/31

TCI Chemical

Product number: R0294
Product name: Reagents for Condensation Reactions (DMT-MM) (HPMC encapsulated)
Packaging: 10EACH
Price: $60
Updated: 2025/07/31

TCI Chemical

Product number: D2919
Product name: 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium Chloride
Purity: >98.0%(N)
Packaging: 5g
Price: $98
Updated: 2025/07/31

TCI Chemical

Product number: D2919
Product name: 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium Chloride
Purity: >98.0%(N)
Packaging: 25g
Price: $280
Updated: 2025/07/31

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4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride Chemical Properties,Usage,Production

Chemical Properties

White powder or chunks

Uses

DMTMM, a conjugating agent that efficiently conjugat PnPS to Luminex microspheres without affecting the antigenicity of a broad set of PnPS.

Uses

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride hydrate is used as a pharmaceutical intermediate. It is used as a reagent for activating carboxylic acids in solution and solid phase peptide synthesis.

Uses

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride can be used as a condensing agent for the following transformations:

Condensation of carboxylic acids and amines to the corresponding amides in tetrahydrofuran.
Esterification of carboxylic acids with alcohols to the corresponding esters.
Conversion of carboxylic acids to the corresponding Weinreb amides in protic solvents.

reaction suitability

reaction type: Coupling Reactions

Synthesis

109-02-4

3140-73-6

3945-69-5

GENERAL METHODS: N-methylmorpholine (NMM, 6.0 mmol) was slowly added dropwise to a stirred solution of 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT, 1.5 mmol) in anhydrous dichloromethane (CH2Cl2, 15 mL) under anhydrous conditions with continuous stirring for 10 min. Subsequently, Schiff base (1.0 mmol) and carboxylic acid (1.5 mmol) were added to the resulting white suspension of 4-(4,6-dimethoxytriazin-2-yl)-4-methylmorpholine hydrochloride (DMTMM salt) and the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was washed sequentially with saturated sodium bicarbonate solution (NaHCO3, 15 mL) and brine (15 mL), dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure. The product was purified by silica gel short column chromatography (with ethyl acetate (EtOAc) as eluent) or by crystallization from 2-azetidinone (3l-m) to give the pure product 2-azetidinone (3a-k, 3n-o).

References

[1] Tetrahedron Letters, 1999, vol. 40, # 29, p. 5327 - 5330
[2] Tetrahedron, 1999, vol. 55, # 46, p. 13159 - 13170
[3] Tetrahedron Letters, 2010, vol. 51, # 1, p. 20 - 22
[4] Letters in Organic Chemistry, 2015, vol. 12, # 1, p. 44 - 49
[5] Tetrahedron Letters, 2002, vol. 43, # 18, p. 3323 - 3326

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride Preparation Products And Raw materials

Raw materials

4-Methylmorpholine Tetrahydrofuran Sodium bicarbonate Methanol PETROLEUM ETHER Cyanuric chloride

Preparation Products

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4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride Suppliers

Americas 1 Belgium 1 Canada 1 China 275 Europe 3 Germany 2 Hungary 1 India 7 Israel 1 Italy 2 Japan 5 South Korea 1 Switzerland 3 United Kingdom 7 United States 29 Global 339

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View Lastest Price from 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride 3945-69-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-15

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride 3945-69-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-30

Anhui Royal Chemical Co., Ltd.

Product: (4,6-DIMETHOXY-1.3.5-TRIAZIN-2-YL)-4-METHYL MORPHOLINIUM CHLORIDE 3945-69-5
Price: US $174.00/kg
Min. Order: 20kg
Purity: 97%
Supply Ability: 500 kg
Release date: 2024-06-17

3945-69-5, 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chlorideRelated Search:

2,2'-Dithiodipyridine MORPHOLINIUM CHLORIDE 2-AMINO-4,6-DIMETHOXY-1,3,5-TRIAZINE 4,4-dimethylmorpholinium chloride AMMELIDE 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride

4(-4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinumChloriden-Hydrate

4-(4,6-DiMethoxy-1,3,5-triazin-2-yl)-4-MethylMorpholiniuM chloride hydrate, 97+%

4-(4,6-Dimethoxy-1,3

4-(4,6-Dimethoxy-s-triazin-2-yl)-4-methyl-morpholinium Chloride

4-(4,6-DiMethoxy-1,3,5-triazin-2-yl)-4-MethylMorpholin-4-iuM chloride/DMTMM

MorpholiniuM,4-(4,6-diMethoxy-1,3,5-triazin-2-yl)-4-Methyl-, chloride (1:1)

4-(4,6-DiMethoxy-1,3,5-triazin-2-yl)-4-MethylMorpholiniuM chloride >=96.0% (calc. on dry substance, AT)

4-(4,6-Dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholinium chloride≥ 97% (HPLC)

DMTMM

KUNISHIMA COUPLING REAGENT

4-(4,6-DIMETHOXY-1,3,5-TRIAZIN-2-YL)-4-METHYLMORPHOLINIUM CHLORIDE

4-(4,6-DIMETHOXY[1.3.5]TRIAZIN-2-YL)-4-METHYLMORPHOLINIUM CHLORIDE HYDRATE

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride, 97.5%

4-(4,6-Dime

4-(4,6-DIMETHOXY-1,3,5-TRIAZIN-2-YL)-4-METHYLMORPHOLINIUM CHLORIDE N-HYDRATE

4-(4,6-DIMETHOXY-[1,3,5]TRIAZIN-2-YL)-4-METHYL-MORPHOLIN-4-IUM, CHLORIDE

4-(4,6-DIMETHOXY-1,3,5-TRIAZINE-2-YL)-4-METHYL MORPHOLINIUM CHLORIDE

4-(4,6-DIMETHOXY-1,3,5-TRIAZINE-2-YL)-4-METHYL MORPHOLINIUM CHLORIDE (DMT-MM)

DMTMM 4-(4,6-DIMETHOXY-1,3,5-TRIAZIN-2-YL)-4-METHYLMORPHOLINIUM CHLORIDE

4-(4,6-DIMETHOXY-1,3,5-TRIAZIN-2-YL)-4-MEMORPHOLINIUM CL

4-(4,6-Dimethoxy-1,3,5-Triazin-2-Yl)-4-MethylmorpholiniumChloride(Dmt-Mm)

4-(4,6-Dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate, 99+%

4-(4,6-DIMETHOXY-1,3,5-TRIAZIN-2-YL)-4-METHYL MORP

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-morpholinium chloride

DMTMM Cl

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride, 98+%

4-4-methylmorpholinium chloride

DMTMM 4-(4,6-DIMETHOXY[1.3.5]TRIAZIN-2-YL)-4-METHYLMORPHOLINIUM CHLORIDE HYDRATE

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride ,99%

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride hydrate, 98+%

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholiniumChloride&gt

DMTMM 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride,98%

4-(4,6-Dimethoxy-1,3,5-triazin-2-yL

4-(4,6-Dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium ch...

TIANFUCHEM--3945-69-5--4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride factory price

(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride

Rivaroxaban Impurity 235

4-(4, 6-dimethoxy-triazine-2-yl) -4-methylmorpholine hydrochloride

Cyclohexanone,3-[(1R)-1-hydroxy-1-phenyl-3-(1-pyrrolidinyl)propyl]-,(3R)-rel-

4- (4,6-Dimethoxytriazin-2-yl) -4-methylmorpholine hydrochloride

DMMTMM

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium Chloride, ≥ 98.0%

4-4-Methylmorpholinium Chloride Hydrate

4,6-DIMETHOXY-1.3.5-TRIAZIN-2-YL

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinehydrochloride

3945-69-5

C10H19ClN4O4

C10H17ClN4O3xH2O

C10H17N4O3Cl

C10H17ClN4O3

C10H17CIN4O3

Coupling

Others

Synthetic Reagents

API intermediates

Biochemistry

Condensation & Active Esterification

Coupling Reactions (Peptide Synthesis)