2,2'-Dithiodipyridine
- Product Name
- 2,2'-Dithiodipyridine
- CAS No.
- 2127-03-9
- Chemical Name
- 2,2'-Dithiodipyridine
- Synonyms
- 1,2-Di(pyridin-2-yl)disulfane;Aldrithiol;2-Aldrithiol;2-PDS;Dithiodipyridine;ALDRITHIOL-2;Dipyridyldisulfide;2-Pyridyl disulfide;1,2-Bis(2-pyridinyl) Disulfide;2PDS
- CBNumber
- CB5200205
- Molecular Formula
- C10H8N2S2
- Formula Weight
- 220.31
- MOL File
- 2127-03-9.mol
2,2'-Dithiodipyridine Property
- Melting point:
- 56-58 °C(lit.)
- Boiling point:
- 356.1±17.0 °C(Predicted)
- Density
- 1.3078 (rough estimate)
- refractive index
- 1.5500 (estimate)
- Flash point:
- 210 °C
- storage temp.
- 2-8°C
- solubility
- methanol: soluble50mg/mL, clear to very slightly hazy, colorless to faintly brownish-yellow
- form
- powder
- pka
- 1.52±0.19(Predicted)
- color
- Clear colorless to yellow to tan
- Water Solubility
- 5 g/L (20 ºC)
- BRN
- 154629
- InChI
- 1S/C10H8N2S2/c1-3-7-11-9(5-1)13-14-10-6-2-4-8-12-10/h1-8H
- InChIKey
- HAXFWIACAGNFHA-UHFFFAOYSA-N
- SMILES
- S(Sc1ccccn1)c2ccccn2
- LogP
- 2.530 (est)
- CAS DataBase Reference
- 2127-03-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Pyridine, 2,2'-dithiobis-(2127-03-9)
- EPA Substance Registry System
- Pyridine, 2,2'-dithiobis- (2127-03-9)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-37-20/22
- Safety Statements
- 36/37/39-37/39-25-22-36-26
- RIDADR
- UN 3335
- WGK Germany
- 3
- F
- 10-23
- Autoignition Temperature
- 340 °C
- Hazard Note
- Irritant
- TSCA
- TSCA listed
- HS Code
- 29333990
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 143049
- Product name
- Aldrithiol?-2
- Purity
- 98%
- Packaging
- 1g
- Price
- $29.6
- Updated
- 2025/07/31
- Product number
- 8.41109
- Product name
- 2,2′-Dipyridyl disulfide
- Purity
- for synthesis
- Packaging
- 5G
- Price
- $132
- Updated
- 2025/07/31
- Product number
- 143049
- Product name
- Aldrithiol?-2
- Purity
- 98%
- Packaging
- 5g
- Price
- $132
- Updated
- 2025/07/31
- Product number
- D1114
- Product name
- 2,2'-Dipyridyl Disulfide [for Peptide Synthesis]
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $54
- Updated
- 2025/07/31
- Product number
- D1114
- Product name
- 2,2'-Dipyridyl Disulfide [for Peptide Synthesis]
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $162
- Updated
- 2025/07/31
2,2'-Dithiodipyridine Chemical Properties,Usage,Production
Chemical Properties
white to yellowish crystalline powder
Uses
2,2'-Dipyridyl disulfide is a useful reagent for determination of sulfhydryl groups, preparation of amino acid active esters and the thio esters of phosphoric acid. It acts as a peptide coupling reagent and as an oxidizing agent. It is also used for the activation of glycosides.
Uses
2,2'-Dipyridyldisulfide, sometimes known as DPS, is used for preparing thiols and activating or protecting carboxylic acid with triphenylphosphine.
Uses
2,2'-Dithiodipyridine was used in the synthesis of adenosine-5′-phosphoimidazolide. It was employed with PPh3 as a condensing agent in the amidation of carboxylic acid enantiomers for HPLC separation.
Definition
ChEBI: Aldrithiol is a member of the class of pyridines that is pyridine which is substituted by a pyridin-2-yldisulfanediyl group at position 2. It is a reagent used in molecular biology as an oxidizing agent. Also used in peptide synthesis and for detecting thiols. It has a role as an oxidising agent. It is an organic disulfide and a member of pyridines.
General Description
2,2'-Dithiodipyridine is a nucleocapsid zinc finger targeting compound and can abrogate the infectivity of human immunodeficiency virus type-1 virions. It is a thiol reagent.
Biochem/physiol Actions
2,2′-Dithiodipyridine mediates inter-unit disulfide cross-linking. It interacts with carbon nucleophiles to yield thiopyridyl derivatives.
Purification Methods
Recrystallise the disulfide H2O from *C6H6/pet ether (6:7), ligroin or *C6H6. The picrate has m 119o (from EtOH). [Walter et al. Justus Liebigs Ann Chem 695 7785 1966, Marckwald et al. Chem Ber 33 1556 1900, Brocklehurst & Little Biochem J 133 67,78 1973, Beilstein 21 III/IV 48.] It has been used as a 1mM solution in EtOH for the spectrophotometric estimation of thiols. Essentially the thiol displaces half the disulfide molecule liberating the 2-mercaptopyridine anion, thereby shifting the from 340nm (of the disulfide) to 268nm (of the anion) at pH 9, or 278nm in H2O. (Compare
2,2'-Dithiodipyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,2'-Dithiodipyridine manufacturers
- Product
- 2,2'-Dithiodipyridine 2127-03-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 20tons
- Release date
- 2025-04-24
- Product
- 2,2'-Dithiodipyridine 2127-03-9
- Price
- US $0.00/G/KG
- Min. Order
- 1G/KG
- Purity
- 99%
- Supply Ability
- 100000000KG
- Release date
- 2025-04-23
- Product
- Vonoprazan Impurity 103 2127-03-9
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 95%+
- Supply Ability
- 1000000
- Release date
- 2024-12-31