ChemicalBook > CAS DataBase List > 2,2'-Dithiodipyridine

2,2'-Dithiodipyridine

Product Name: 2,2'-Dithiodipyridine
CAS No.: 2127-03-9
Chemical Name: 2,2'-Dithiodipyridine
Synonyms: 1,2-Di(pyridin-2-yl)disulfane;Aldrithiol;2-Aldrithiol;2-PDS;Dithiodipyridine;ALDRITHIOL-2;Dipyridyldisulfide;2-Pyridyl disulfide;1,2-Bis(2-pyridinyl) Disulfide;2PDS
CBNumber: CB5200205
Molecular Formula: C10H8N2S2
Formula Weight: 220.31
MOL File: 2127-03-9.mol

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2,2'-Dithiodipyridine Property

Melting point:: 56-58 °C(lit.)
Boiling point:: 356.1±17.0 °C(Predicted)
Density: 1.3078 (rough estimate)
refractive index: 1.5500 (estimate)
Flash point:: 210 °C
storage temp.: 2-8°C
solubility: methanol: soluble50mg/mL, clear to very slightly hazy, colorless to faintly brownish-yellow
form: powder
pka: 1.52±0.19(Predicted)
color: Clear colorless to yellow to tan
Water Solubility: 5 g/L (20 ºC)
BRN: 154629
InChIKey: HAXFWIACAGNFHA-UHFFFAOYSA-N
LogP: 2.530 (est)
CAS DataBase Reference: 2127-03-9(CAS DataBase Reference)
NIST Chemistry Reference: Pyridine, 2,2'-dithiobis-(2127-03-9)
EPA Substance Registry System: Pyridine, 2,2'-dithiobis- (2127-03-9)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-37-20/22
Safety Statements: 36/37/39-37/39-25-22-36-26
RIDADR: UN 3335
WGK Germany: 3
F: 10-23
Autoignition Temperature: 340 °C
Hazard Note: Irritant
TSCA: Yes
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 143049
Product name: Aldrithiol?-2
Purity: 98%
Packaging: 1g
Price: $29.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.41109
Product name: 2,2′-Dipyridyl disulfide
Purity: for synthesis
Packaging: 5G
Price: $132
Updated: 2025/07/31

Sigma-Aldrich

Product number: 143049
Product name: Aldrithiol?-2
Purity: 98%
Packaging: 5g
Price: $132
Updated: 2025/07/31

TCI Chemical

Product number: D1114
Product name: 2,2'-Dipyridyl Disulfide [for Peptide Synthesis]
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $54
Updated: 2025/07/31

TCI Chemical

Product number: D1114
Product name: 2,2'-Dipyridyl Disulfide [for Peptide Synthesis]
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $162
Updated: 2025/07/31

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2,2'-Dithiodipyridine Chemical Properties,Usage,Production

Chemical Properties

white to yellowish crystalline powder

Uses

2,2'-Dipyridyl disulfide is a useful reagent for determination of sulfhydryl groups, preparation of amino acid active esters and the thio esters of phosphoric acid. It acts as a peptide coupling reagent and as an oxidizing agent. It is also used for the activation of glycosides.

Uses

2,2'-Dipyridyldisulfide, sometimes known as DPS, is used for preparing thiols and activating or protecting carboxylic acid with triphenylphosphine.

Uses

2,2'-Dithiodipyridine was used in the synthesis of adenosine-5′-phosphoimidazolide. It was employed with PPh₃ as a condensing agent in the amidation of carboxylic acid enantiomers for HPLC separation.

Definition

ChEBI: Aldrithiol is a member of the class of pyridines that is pyridine which is substituted by a pyridin-2-yldisulfanediyl group at position 2. It is a reagent used in molecular biology as an oxidizing agent. Also used in peptide synthesis and for detecting thiols. It has a role as an oxidising agent. It is an organic disulfide and a member of pyridines.

General Description

2,2'-Dithiodipyridine is a nucleocapsid zinc finger targeting compound and can abrogate the infectivity of human immunodeficiency virus type-1 virions. It is a thiol reagent.

Biochem/physiol Actions

2,2′-Dithiodipyridine mediates inter-unit disulfide cross-linking. It interacts with carbon nucleophiles to yield thiopyridyl derivatives.

Purification Methods

Recrystallise the disulfide H2O from *C6H6/pet ether (6:7), ligroin or *C6H6. The picrate has m 119o (from EtOH). [Walter et al. Justus Liebigs Ann Chem 695 7785 1966, Marckwald et al. Chem Ber 33 1556 1900, Brocklehurst & Little Biochem J 133 67,78 1973, Beilstein 21 III/IV 48.] It has been used as a 1mM solution in EtOH for the spectrophotometric estimation of thiols. Essentially the thiol displaces half the disulfide molecule liberating the 2-mercaptopyridine anion, thereby shifting the from 340nm (of the disulfide) to 268nm (of the anion) at pH 9, or 278nm in H2O. (Compare

2,2'-Dithiodipyridine Preparation Products And Raw materials

Raw materials

Preparation Products

Finasteride

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View Lastest Price from 2,2'-Dithiodipyridine manufacturers

Chongqing Chemdad Co., Ltd

Product: 2,2'-Dithiodipyridine 2127-03-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 20tons
Release date: 2025-04-24

Anhuyan (Hainan) Biotechnology Co., LTD

Product: 2,2'-Dithiodipyridine 2127-03-9
Price: US $0.00/G/KG
Min. Order: 1G/KG
Purity: 99%
Supply Ability: 100000000KG
Release date: 2025-04-23

Moxin Chemicals

Product: Vonoprazan Impurity 103 2127-03-9
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 1000000
Release date: 2024-12-31

2127-03-9, 2,2'-Dithiodipyridine Related Search:

2,5-PYRIDINEDICARBOXYLIC ACID Diallyldisulfide Dimethyl disulfide THIODIGLYCOLIC ACID 2,2'-Bipyridine Pyridine Dibenzyl disulfide 2,6-Lutidine Allicin Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 2,2'-DITHIOBIS(5-NITROPYRIDINE) 6,6'-DITHIODINICOTINIC ACID Bispyrithione 4,4'-DITHIODIPYRIDINE,4,4Dipyridyldisulfide-(4,4dithiodipyridine) GGKPDLRPCHPPCHYIPRPKPR 2,2'-Dithiodipyridine 4,4'-DIPYRIDYL DISULPHIDE, (4,4'-DITHIODIPYRIDINE) DI[5-(TRIFLUOROMETHYL)-2-PYRIDYL] DISULFIDE

NSC 94055

1,2-Di(pyridin-2-yl)disulfane

2,2'-Disulphanediyldipyridine, 2,2'-Dithiodipyridine

Di(pyridin-2-yl) disulphide

Aldrithiol(TM)-2 98%

1,2-Di(pyridin-2-yl)disulfide

2-(2-Pyridinyldisulfanyl)pyridine

2,2'-Dipyridinyl disulfide

2,2'-Dithiobis(pyridine)

2,2'-Dithiopyridine

2-Dipyridyl disulfide

2PDS

2-Pyridyl disulfide

Aldrithol-2

2,2'-Dithiodipyridine, >=99%

Bis(pyridin-2-yl) disulfide

Aldrithiol

2,2μ-Dipyridyl disulfide, 2,2μ-Dithiodipyridine

Aldritiol

Di(2-pyridyl) persulfide

Dithiodipyridine

2,2'-Dithiodipyridine,98%

2,2'-Dithiodipyridin

Bis(pyridin-2-yl) disulphide

2,2'- Dipyridil disulfide

2-(pyridin-2-yldisulfanyl)pyridine

1,2-Bis(2-pyridinyl) Disulfide

2,2'-Bipyridyldisulfide

2-Aldrithiol

1,2-Di(pyridin-2-yl

Bis(2-pyridinyl) disulfide

Bis(2-pyridyl) disulfide

Di-2-Pyridyl disulfide

Nsc 677438

Pyridine, 2,2'-dithiodi-

ALDRITHIOL-2

ALDRITHIOL(TM)-2

2,2'-DIPYRIDYL DISULPHIDE

2-(PYRIDIN-2-YLDITHIO)PYRIDINE

2-PYRIDINYL DISULFIDE

2-PDS

2,2'-Dipyridyl Disulfide [for Peptide Synthesis]

Dipyridyldisulfide

Pyridine, 2,2-dithiobis-

2,2''-DIPYRIDYL DISULFIDE 98+%

Di(pyridin-2-yl) disulfide

2,2'-Dipyridyl disulfide, 98%, for synthesis

2,2'-DipyridylDisulfide[forPeptideSynthesis]&gt

2,2'-DIPYRIDYL DISULFIDE FOR SYNTHESIS

2,2'-Dithiodipyridine ISO 9001：2015 REACH

2-(2-Pyridyldisulfanyl)pyridine

9-[(3aS,6aR)-6-(hydroxymethyl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-3H-purin-6-one

2,2'-Dithiodipyridine

2,2'-Dipyridyl disulfide

2,2'-Dipyridyl disulfide|||OPSS|||Aldrithiol 2|||Orthopyridyl disulfide

2,2''-Dithiodipyridine

2,2'-Dithiodipyridin

Aldrithiol<sup>?</sup>-2