Cefdinir
Brand Name(s) in US- Product Name
- Cefdinir
- CAS No.
- 91832-40-5
- Chemical Name
- Cefdinir
- Synonyms
- Omnicef;Cefzon;CFDN;Omnice;FK-482;CI 983;Novacef;cefdinyl;bmy28488;CEFDINIR
- CBNumber
- CB7483101
- Molecular Formula
- C14H13N5O5S2
- Formula Weight
- 395.41
- MOL File
- 91832-40-5.mol
Cefdinir Property
- Melting point:
- >180°C dec.
- Density
- 1.89±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- dilute HCl: slightly soluble
- pka
- 9.70(at 25℃)
- form
- solid
- color
- Pale Yellow to Light Yellow
- Water Solubility
- Soluble in water
- λmax
- 295nm(DMSO)(lit.)
- Merck
- 14,1920
- BCS Class
- 4
- InChI
- InChI=1S/C14H13N5O5S2/c1-2-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24)6-4-26-14(15)16-6/h2,4,8,12,24H,1,3H2,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/s1
- InChIKey
- RTXOFQZKPXMALH-GHXIOONMSA-N
- SMILES
- N12[C@@]([H])([C@H](NC(/C(/C3=CSC(N)=N3)=N\O)=O)C1=O)SCC(C=C)=C2C(O)=O
- CAS DataBase Reference
- 91832-40-5(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- RTECS
- XI0367250
- HS Code
- 2941906000
- Toxicity
- LD50 orl-rat: >5600 mg/kg IYKEDH 23,93,1992
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C7118
- Product name
- Cefdinir
- Purity
- ≥95% (HPLC)
- Packaging
- 1g
- Price
- $160
- Updated
- 2023/06/20
- Product number
- C3111
- Product name
- Cefdinir
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $105
- Updated
- 2024/03/01
- Product number
- C3111
- Product name
- Cefdinir
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $263
- Updated
- 2024/03/01
- Product number
- J66447
- Product name
- Cefdinir, 95%
- Packaging
- 1g
- Price
- $136
- Updated
- 2024/03/01
- Product number
- J66447
- Product name
- Cefdinir, 95%
- Packaging
- 5g
- Price
- $415.65
- Updated
- 2024/03/01
Cefdinir Chemical Properties,Usage,Production
Brand Name(s) in US
Omnicef
Description
Cefdinir is a cephalosporin antibiotic. It is active against numerous Gram-positive and Gram-negative bacteria, including β-lactamase-producing E. coli, K. oxytoca, K. pneumoniae, and P. aeruginosa clinical isolates (MICs = 0.25-16 μg/ml). Cefdinir is protective against sepsis induced by strains of S. aureus or H. influenzae in mice with 50% protective dose (PD50) values of 2.7-35 and 3.1-5.8 mg/kg, respectively. Formulations containing cefdinir have been used in the treatment of Gram-positive and Gram-negative infections.
Description
Cefdinir is an orally active, beta-lactamase stable cephalosporin with a broad spectrum of activity. Compared to other oral cephalosporins, cefdinir is more potent against Gram-positive bacteria, especially Staphylococci. Its activity against Gram-negative bacteria such as E.coli,K. pneumoniae and P.mirabilis is similar to cefixime, but superior to cefaclor and cephalexin.
Chemical Properties
Pale Yellow Solid
Originator
Fujisawa (Japan)
Uses
A Cephalosporin antibiotic structurally similar to Cefixime
Uses
antihypertensive, ACE inhibitor
Uses
A broad spectrum antibiotic targeting both Gram-positive and Gram-negative pathogens
Definition
ChEBI: A cephalosporin compound having 7beta-2-(2-amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino- and 3-vinyl side groups.
Manufacturing Process
By interaction of 7-amino-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-
2-carboxylic acid 4-methoxyphenyl ester with 4-bromoacetyl bromide was
prepared 7-(4-bromo-3-oxo-butyrylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo
(4.2.0)oct-2-ene-2-carboxylic acid 4-methoxyphenyl ester. The active
methylene group in that product was then nitrosated with sodium nitrite. The
initial product spontaneously tautomerizes to afford 7-(4-bromo-2-
hydroxyimino-3-oxo-butyrylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)
oct-2-ene-2-carboxylic acid 4-methoxyphenyl ester. By the reaction of that
compound with thiourea and then with trifluoroacetic acid was obtained
(6R,7R)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-8-oxo-3-vinyl-5-thia-1-
azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sodium nitrite, (Z)-oxime
(Cefdinir sodium nitrile).
In practice it is usually used as free acid.
Synthesis of 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trytiloxyimino)acetamido]-3-
vinyl-3-cephem-4-carboxylic acid x p-toluenesulfonic acid x 2 N,N-dimethylacetamide (the precursor of Cefdinir) was described in Patent US
6,093,814.
brand name
Cefzon
Therapeutic Function
Antibiotic
Antimicrobial activity
An oral cephalosporin similar in structure to cefixime, but
with a slightly modified side chain at the 7-amino position.
Activity is similar to that of cefixime, but it is more active,
especially against staphylococci. It is not hydrolyzed
by staphylococcal or the common plasmid-mediated
enterobacterial β-lactamases. An enhancing effect on phagocytosis
has been demonstrated in vitro.
Oral absorption is about 35%. A 200 mg oral dose achieves
a plasma concentration of 1 mg/L after c. 3 h. Absorption is
reduced after a fatty meal. Concentrations equal to or higher
than corresponding plasma levels were present in blister fluid
6–12 h after administration of an oral dose. The plasma halflife
is 1.5 h. Protein binding is 60–70%. A total of 12–20%
of the dose was excreted in the urine within 12 h, the renal
elimination declining with increasing dose. The elimination
half-life and peak plasma concentration are increased in renal
failure. About 60% of the drug is removed by hemodialysis.
Side effects and uses are those common to oral
cephalosporins.
Safety Profile
Moderately toxic by ingestion andintravenous routes. Low toxicity by intraperitoneal andsubcutaneous routes. Experimental reproductive effects.When heated to decomposition it emits toxic vapors ofNOx and SOx.
Cefdinir Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cefdinir manufacturers
- Product
- Cefdinir 91832-40-5
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- More than 99%
- Supply Ability
- 2000KG/MONTH
- Release date
- 2024-04-24
- Product
- Cefdinir 91832-40-5
- Price
- US $0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2024-04-09
- Product
- Cefdinir 91832-40-5
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000000
- Release date
- 2023-12-27