Doxazosin

ChemicalBook > CAS DataBase List > Doxazosin

Product Name: Doxazosin
CAS No.: 74191-85-8
Chemical Name: Doxazosin
Synonyms: UK 33274;UK 33,274;DOXAZOSIN;Doxazosin base;DOXAZOSINMESYTL;DOXAZOSIN(CARDULAR);Doxazosin USP/EP/BP;Doxazosin (UK 33274);Doxazosin Mesylate USP;DOXAZOSIN(SUBJECTTOPATENTFREE)
CBNumber: CB7216507
Molecular Formula: C23H25N5O5
Formula Weight: 451.48
MOL File: 74191-85-8.mol

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Doxazosin Property

Melting point:: 289-290°C
Boiling point:: 718.0±70.0 °C(Predicted)
Density: 1.371±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 6.52±0.50(Predicted)
CAS DataBase Reference: 74191-85-8(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H373May cause damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B1209
Product name: Doxazosin
Packaging: 100mg
Price: $142
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002486
Product name: DOXAZOSIN
Purity: 95.00%
Packaging: 100MG
Price: $205.8
Updated: 2021/12/16

ApexBio Technology

Product number: B1209
Product name: Doxazosin
Packaging: 500mg
Price: $434
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002486
Product name: DOXAZOSIN
Purity: 95.00%
Packaging: 1G
Price: $721.57
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002486
Product name: DOXAZOSIN
Purity: 95.00%
Packaging: 2.5G
Price: $983.88
Updated: 2021/12/16

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Doxazosin Chemical Properties,Usage,Production

Description

Doxazosin mesylate is a selective alpha, blocker indicated for the treatment of hypertension, reportedly of special benefit as a first-line agent in the most hypertonic patient population. Another advantage of doxazosin is its favorable effect on blood lipids; it significantly increases the HDL/total cholesterol ratio and decreases the total cholesterol as well as triglycerides levels.

Originator

Pfizer (United Kingdom)

Uses

ACIPHEX therapeutic Erosive or Ulcerative Gastroesophageal Reflux Disease

Definition

ChEBI: A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl roup at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.

brand name

Cardura (Pfizer);Carduran.

General Description

Doxazosin, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazine(Cardura), is a quinazoline compound that selectively inhibitsthe α1-subtype of α-adrenergic receptors. This agentis very useful in the management of hypertension associatedwith pheochromocytoma.

Clinical Use

Alpha-adrenoceptor blocker:
Hypertension
Benign prostatic hyperplasia (BPH)

Drug interactions

Potentially hazardous interactions with other drugs
Antidepressants: enhanced hypotensive effect with MAOIs.
Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect, avoid with tadalafil, start the others at the lowest possible dose.
Beta-blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Calcium-channel blockers: enhanced hypotensive effect, increased risk of first dose hypotensive effect.
Diuretics: enhanced hypotensive effect, increased risk of first dose hypotensive effect.
Moxisylyte: possibly severe postural hypotension when used in combination.

Metabolism

Doxazosin is extensively metabolised in the liver, and excreted in faeces as inactive metabolites (6-hydroxydoxazosin) and a small amount of unchanged drug

Doxazosin Preparation Products And Raw materials

Raw materials

2-(5-methyl-2-propan-2-yl-phenoxy)ethanamine 2-(1-Piperazinyl)pyrimidine ETHYLENE OXIDE Quinazoline

Preparation Products

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View Lastest Price from Doxazosin manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: Doxazosin 74191-85-8
Price: US $1.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-07

Zhuozhou Wenxi import and Export Co., Ltd

Product: Doxazosin 74191-85-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Doxazosin 74191-85-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

74191-85-8, DoxazosinRelated Search:

Prazosin Prazosin hydrochloride Tamsulosin Doxazosin mesylate Terazosin Azoazine intermediate Quinazoline Benzene 1,4-Benzodioxan DOXAZOSIN-D8 (PIPERAZINE-D8) 6'-HYDROXY DOXAZOSIN DOXAZOSIN MALEATE Doxazosin

[4-(4-amino-6,7-dimethoxy-quinazolin-2- yl)piperazin-1-yl]-(2,5-dioxabi cyclo[4.4.0]deca-6,8,10-trien-4-yl)methanone

DOXAZOSIN

DoxazosinMesylate77883-43-3/Base

DOXAZOSIN(SUBJECTTOPATENTFREE)

[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methanone

Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-

UK 33,274

UK 33274

4-Amino-2-[4-(1，4-benzodioxan-2-carbonyl)piperazin-1-y1]-6，7-dimethoxy quinazoline

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine

1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine

6,7-Dimethoxy-2-[4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-1-piperazinyl]quinazoline-4-amine

DOXAZOSINMESYTL

1-(4-aMino-6,7-diMethoxy-quinazolin-2-yl)-4-(2,3-dihydro-benzo[1,4]dioxine-2-carbonyl)-piperazine

DOXAZOSIN(CARDULAR)

(4-(4-aMino-6,7-diMethoxyquinazolin-2-yl)piperazin-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)Methanone

Doxazosin Mesylate USP

Methanone,[4-(4-aMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl](2,3-dihydro-1,4-benzodioxin-2-yl)-

Doxazosin USP/EP/BP

Doxazosin base

Doxazosin (UK 33274)

DoxazosinQ: What is Doxazosin Q: What is the CAS Number of Doxazosin Q: What is the storage condition of Doxazosin

COc5cc4nc(N3CCN(C(=O)C2COc1ccccc1O2)CC3)nc(N)c4cc5OC

74191-85-8

74191-85-5

C23H25N5O5

API

API, Trade Name: Cardura & Carduran

Doxazosin

Pharmaceutical