Methyl 3-aminocrotonate

Product Name: Methyl 3-aminocrotonate
CAS No.: 14205-39-1
Chemical Name: Methyl 3-aminocrotonate
Synonyms: Methyl (Z)-3-Aminobut-2-enoate;3-Aminocrotonate;(Z)-Methyl 3-aMinobut-2-enoate;methyl (E)-3-aminobut-2-enoate;3-Amino-but-2-enoic acid methyl ester;PALO-012;Nifedipine-4;Methyl 3-aminocroton;Nifedipine Impurity 5;Methyl 3-aminocrotote
CBNumber: CB2222855
Molecular Formula: C5H9NO2
Formula Weight: 115.13
MOL File: 14205-39-1.mol

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Methyl 3-aminocrotonate Property

Melting point:: 81-83 °C(lit.)
Boiling point:: 112°C 42mm
Density: 1.1808 (rough estimate)
vapor pressure: 2.79-2.853hPa at 25℃
refractive index: 1.4538 (estimate)
Flash point:: 91 °C
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: 18g/l
form: Crystalline Powder
pka: 5.27±0.70(Predicted)
color: White to slightly yellow
PH: 8-9 (18g/l, H2O, 20℃)
Water Solubility: insoluble
Sensitive: Hygroscopic
BRN: 956592
InChIKey: XKORCTIIRYKLLG-ONEGZZNKSA-N
LogP: -0.27 at 25℃
CAS DataBase Reference: 14205-39-1(CAS DataBase Reference)
EPA Substance Registry System: 2-Butenoic acid, 3-amino-, methyl ester (14205-39-1)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 37/39-26-24/25
WGK Germany: 3
RTECS: EM9092500
TSCA: Yes
HS Code: 29224995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 129712
Product name: Methyl 3-aminocrotonate
Purity: 97%
Packaging: 100g
Price: $54.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 129712
Product name: Methyl 3-aminocrotonate
Purity: 97%
Packaging: 500g
Price: $54.8
Updated: 2024/03/01

TCI Chemical

Product number: A1001
Product name: Methyl 3-Aminocrotonate
Purity: >98.0%(T)
Packaging: 25g
Price: $16
Updated: 2024/03/01

TCI Chemical

Product number: A1001
Product name: Methyl 3-Aminocrotonate
Purity: >98.0%(T)
Packaging: 500g
Price: $90
Updated: 2024/03/01

Alfa Aesar

Product number: B24953
Product name: Methyl 3-aminocrotonate, 97%
Packaging: 500g
Price: $95.3
Updated: 2024/03/01

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Methyl 3-aminocrotonate Chemical Properties,Usage,Production

Chemical Properties

Crystals, yellowish-white

Uses

Methyl 3-aminocrotonate is used as intermediate for the syntheses of pharmaceuticals (e.g. 1,4-dihydropyridine derivatives) as well as for the manufacture of stabilizers and plastics. Product Data Sheet

Uses

Methyl 3-aminocrotonate (Methyl 3-amino-2-butenoate) was used to synthesize 4-aryl-1,4-dihydropyridines possessing potential calcium channel blocking activity.

Uses

Nitrendipine (N490150) metabolite. The pharmacokinetics of Nitrendipine was studied in the rat and 6 major metabolites were identified.

Preparation

3-Aminocrotonate Esters, e.g., methyl 3- aminocrotonate [14205-39-1] (3-amino-2-butenoic acid, methyl ester) can be prepared by treatment of acetoacetates with aqueous ammonia. They are mainly used in the production of a series of the dihydropyridine-type calcium antagonists.

General Description

Methyl 3-aminocrotonate undergoes waste-free solid-state cascade reaction with crystalline ninhydrin.

Flammability and Explosibility

Not classified

Methyl 3-aminocrotonate Preparation Products And Raw materials

Raw materials

Preparation Products

Benidipine Cilnidipine Isradipine Nitrendipine Felodipine Manidipine Nisoldipine Amlodipine

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Methyl 3-aminocrotonate Suppliers

Americas 1 Belgium 2 Canada 2 China 383 Europe 4 Germany 7 India 83 Italy 1 Japan 6 Slovakia 1 South Korea 2 Switzerland 6 United Kingdom 14 United States 56 Global 568

XI'AN VEDA CHEMICAL CO.,LTD

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Energy Chemical

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View Lastest Price from Methyl 3-aminocrotonate manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Methyl 3-aminocrotonate 14205-39-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-04-15

Hebei Mojin Biotechnology Co., Ltd

Product: Methyl 3-aminocrotonate 14205-39-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-04

Hebei Guanlang Biotechnology Co., Ltd.

Product: Methyl 3-aminocrotonate 14205-39-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-08-18

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14205-39-1

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Aromatic Amino Acids

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Carbonyl Compounds

Building Blocks