ChemicalBook > CAS DataBase List > Manidipine

Manidipine

Product Name
Manidipine
CAS No.
89226-50-6
Chemical Name
Manidipine
Synonyms
Artedil;Iperten;Manidipine;Franidipine;Manidipine 6300;Manidipine（base）;Manidipine(CV-4093);Manidipine (Manyper);Manidipine Impurity1254;Manidipine (10mM in DMSO)
CBNumber
CB4506757
Molecular Formula
C35H38N4O6
Formula Weight
610.7
MOL File
89226-50-6.mol
More
Less

Manidipine Property

Melting point:
125-128°C
Boiling point:
722.0±60.0 °C(Predicted)
Density 
1.232±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
Soluble in DMSO > 10 mM
form 
Powder
pka
6.12±0.10(Predicted)
color 
Light yellow to yellow
LogP
4.135
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
23614
Product name
Manidipine
Purity
≥98%
Packaging
10mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
23614
Product name
Manidipine
Purity
≥98%
Packaging
25mg
Price
$206
Updated
2024/03/01
Cayman Chemical
Product number
23614
Product name
Manidipine
Purity
≥98%
Packaging
50mg
Price
$352
Updated
2024/03/01
TRC
Product number
M164000
Product name
Manidipine
Packaging
1g
Price
$725
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
11462
Product name
Manidipine
Packaging
100mg
Price
$425
Updated
2021/12/16
More
Less

Manidipine Chemical Properties,Usage,Production

Description

Manidipine is a dihydropyridine L- and T-type calcium channel blocker. It blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; ) in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively). In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol when administered at a dose of 3 mg/kg. Formulations containing manidipine have been used in the treatment of hypertension.

Chemical Properties

Light Yellow Crystalline Solid

Uses

A dihydropyridine calcium channel blocker. Antihypertensive.

Uses

Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. It causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. It

Definition

ChEBI: Manidipine is a diarylmethane.

Synthesis

89226-75-5

89226-50-6

Synthesis of 3-(2-(4-diphenylmethylpiperazin-1-yl)ethyl)-5-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride as 3-(2-(4-diphenylmethylpiperazin-1-yl)ethyl)-5-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3 ,5-dicarboxylate in the following general steps: 1. 12 g of sodium hydroxide was weighed and 18 mL of water was added to prepare a 40% aqueous sodium hydroxide solution and cooled in an ice bath. 2. add manidipine hydrochloride (20.5 g) to a 500 mL three-necked flask pre-cooled in an ice bath with 100 mL of water. 3. With stirring on, slowly add the pre-prepared ice-cold 40% sodium hydroxide solution dropwise to the three-necked flask. 4. During the dropwise addition, 90mL of ethyl acetate was added. 5. After all bases are added, stop stirring and let stand for stratification. 6. After determining the pH of the aqueous phase to be 11-12, the liquid phase was separated. 7. The aqueous phase was extracted twice with ethyl acetate (30mL x 2) and the organic phases were combined. 8. The combined organic phases were washed once with water (50mL) and once with saturated sodium chloride solution (50mL). 9. The organic phase was dried with anhydrous sodium sulfate (15 g) for 2 hours. 10. After filtration, about 35 parts of the solvent were removed by evaporation under reduced pressure to give a yellow solid manidipine free base in 98% yield.

References

[1] Patent: CN105439942, 2016, A. Location in patent: Paragraph 0040; 0041; 0042

Manidipine Preparation Products And Raw materials

Raw materials

Manidipine Acetyl ketene Methyl 3-aminocrotonate Manidipine hydrochloride 1-(2-Hydroxyethyl)piperazine Diisopropyl ether Magnesium sulfate

Preparation Products

More
Less

Manidipine Suppliers

Canada 1 China 124 Germany 1 India 2 United Kingdom 1 United States 20 Global 149
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
More
Less

View Lastest Price from Manidipine manufacturers

Moxin Chemicals
Product
Manidipine Impurity 89226-50-6
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98
Supply Ability
10000000
Release date
2025-02-22
Zhuozhou Wenxi import and Export Co., Ltd
Product
Manidipine 89226-50-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Manidipine 89226-50-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

89226-50-6, ManidipineRelated Search:

Dimethyl sulfide N,N-Dimethylformamide Manidipine hydrochloride Nifedipine Dichlorodiphenylsilane Nimodipine 1,5-Diphenylcarbazide 1,3-Diphenyl-2-thiourea Amlodipine 3,4'-DIAMINODIPHENYLMETHANE Dimethyl fumarate Dimethyl ether Chlorodiphenylphosphine Dimethyl sulfoxide Dimethyl phthalate Diphenyldimethoxysilane ETHANE Methyl

  • Manidipine(CV-4093)
  • MANIDIPINE;CV-4093;FRANIDIPINE;(±)-MANIDIPINE
  • 2-(4-Diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(diphenylmethyl)-1-piperazinyl)ethyl methyl ester
  • 89226-75-5 (Di-hydrochloride)
  • 1-diphenylmethyl-4-(2-hydroxyethyl)piperazine
  • 3-{2-[4-(diphenylMethyl)piperazin-1-yl]ethyl} 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Manidipine (Manyper)
  • 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester
  • MANIDIPINE: MANIDIPINE DIHYDROCHLORIDE
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester (9CI)
  • Franidipine
  • Manidipine 6300
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] ester
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 5-methyl 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] ester
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-[2-[4-(diphenylmethyl)piperazin-1-yl]ethyl]5-methyl ester
  • 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridi
  • 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester
  • Manidipine（base）
  • 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl]5-methyl ester
  • Manidipine
  • 2-(4-(Diphenylmethyl)-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Artedil
  • Iperten
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester
  • Manidipine (10mM in DMSO)
  • Manidipine Impurity1254
  • Calcium Channel,Manidipine,Inhibitor,inhibit,Ca channels,Ca2+ channels
  • 89226-50-6
  • 120096-68-4
  • Inhibitors
  • Artedil, Iperten
  • Dihydropyridine
  • Dihydropyridine Class Chemicals
  • Intermediates & Fine Chemicals
  • Pharmaceuticals