ChemicalBook > CAS DataBase List > Manidipine

Manidipine

Product Name
Manidipine
CAS No.
89226-50-6
Chemical Name
Manidipine
Synonyms
Artedil;Iperten;Manidipine;Franidipine;Manidipine 6300;Manidipine（base）;Manidipine(CV-4093);Manidipine (Manyper);Manidipine Impurity1254;Manidipine (10mM in DMSO)
CBNumber
CB4506757
Molecular Formula
C35H38N4O6
Formula Weight
610.7
MOL File
89226-50-6.mol
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Manidipine Property

Melting point:
125-128°C
Boiling point:
722.0±60.0 °C(Predicted)
Density 
1.232±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
Soluble in DMSO > 10 mM
form 
Powder
pka
6.12±0.10(Predicted)
LogP
4.135
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23614
Product name
Manidipine
Purity
≥98%
Packaging
10mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
23614
Product name
Manidipine
Purity
≥98%
Packaging
25mg
Price
$206
Updated
2024/03/01
Cayman Chemical
Product number
23614
Product name
Manidipine
Purity
≥98%
Packaging
50mg
Price
$352
Updated
2024/03/01
TRC
Product number
M164000
Product name
Manidipine
Packaging
1g
Price
$725
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
11462
Product name
Manidipine
Packaging
100mg
Price
$425
Updated
2021/12/16
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Manidipine Chemical Properties,Usage,Production

Description

Manidipine is a dihydropyridine L- and T-type calcium channel blocker. It blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; ) in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively). In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol when administered at a dose of 3 mg/kg. Formulations containing manidipine have been used in the treatment of hypertension.

Chemical Properties

Light Yellow Crystalline Solid

Uses

A dihydropyridine calcium channel blocker. Antihypertensive.

Uses

Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. It causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. It

Definition

ChEBI: Manidipine is a diarylmethane.

Manidipine Preparation Products And Raw materials

Raw materials

Manidipine Acetyl ketene Methyl 3-aminocrotonate Manidipine hydrochloride 1-(2-Hydroxyethyl)piperazine Diisopropyl ether Magnesium sulfate

Preparation Products

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Manidipine Suppliers

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View Lastest Price from Manidipine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Manidipine 89226-50-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Manidipine 89226-50-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
Manidipine 89226-50-6
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-23

89226-50-6, ManidipineRelated Search:

Dimethyl sulfide N,N-Dimethylformamide Manidipine hydrochloride Nifedipine Dichlorodiphenylsilane Nimodipine 1,5-Diphenylcarbazide 1,3-Diphenyl-2-thiourea Amlodipine 3,4'-DIAMINODIPHENYLMETHANE Dimethyl fumarate Dimethyl ether Chlorodiphenylphosphine Dimethyl sulfoxide Dimethyl phthalate Diphenyldimethoxysilane ETHANE Methyl

  • Manidipine(CV-4093)
  • MANIDIPINE;CV-4093;FRANIDIPINE;(±)-MANIDIPINE
  • 2-(4-Diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(diphenylmethyl)-1-piperazinyl)ethyl methyl ester
  • 89226-75-5 (Di-hydrochloride)
  • 1-diphenylmethyl-4-(2-hydroxyethyl)piperazine
  • 3-{2-[4-(diphenylMethyl)piperazin-1-yl]ethyl} 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Manidipine (Manyper)
  • 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester
  • MANIDIPINE: MANIDIPINE DIHYDROCHLORIDE
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester (9CI)
  • Franidipine
  • Manidipine 6300
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] ester
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 5-methyl 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] ester
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-[2-[4-(diphenylmethyl)piperazin-1-yl]ethyl]5-methyl ester
  • 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridi
  • 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester
  • Manidipine（base）
  • 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl]5-methyl ester
  • Manidipine
  • 2-(4-(Diphenylmethyl)-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Artedil
  • Iperten
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester
  • Manidipine (10mM in DMSO)
  • Manidipine Impurity1254
  • Calcium Channel,Manidipine,Inhibitor,inhibit,Ca channels,Ca2+ channels
  • 89226-50-6
  • 120096-68-4
  • Inhibitors
  • Artedil, Iperten
  • Dihydropyridine
  • Dihydropyridine Class Chemicals
  • Intermediates & Fine Chemicals
  • Pharmaceuticals