Methyl 3-aminocrotonate
- Product Name
- Methyl 3-aminocrotonate
- CAS No.
- 14205-39-1
- Chemical Name
- Methyl 3-aminocrotonate
- Synonyms
- Methyl (Z)-3-Aminobut-2-enoate;3-Aminocrotonate;(Z)-Methyl 3-aMinobut-2-enoate;methyl (E)-3-aminobut-2-enoate;3-Amino-but-2-enoic acid methyl ester;PALO-012;Nifedipine-4;Methyl 3-aminocroton;Nifedipine Impurity 5;Methyl 3-aminocrotote
- CBNumber
- CB2222855
- Molecular Formula
- C5H9NO2
- Formula Weight
- 115.13
- MOL File
- 14205-39-1.mol
Methyl 3-aminocrotonate Property
- Melting point:
- 81-83 °C(lit.)
- Boiling point:
- 112°C 42mm
- Density
- 1.1808 (rough estimate)
- vapor pressure
- 2.79-2.853hPa at 25℃
- refractive index
- 1.4538 (estimate)
- Flash point:
- 91 °C
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- 18g/l
- form
- Crystalline Powder
- pka
- 5.27±0.70(Predicted)
- color
- White to slightly yellow
- PH
- 8-9 (18g/l, H2O, 20℃)
- Water Solubility
- insoluble
- Sensitive
- Hygroscopic
- BRN
- 956592
- InChIKey
- XKORCTIIRYKLLG-ONEGZZNKSA-N
- LogP
- -0.27 at 25℃
- CAS DataBase Reference
- 14205-39-1(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Butenoic acid, 3-amino-, methyl ester (14205-39-1)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 37/39-26-24/25
- WGK Germany
- 3
- RTECS
- EM9092500
- TSCA
- Yes
- HS Code
- 29224995
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 129712
- Product name
- Methyl 3-aminocrotonate
- Purity
- 97%
- Packaging
- 100g
- Price
- $54.6
- Updated
- 2024/03/01
- Product number
- 129712
- Product name
- Methyl 3-aminocrotonate
- Purity
- 97%
- Packaging
- 500g
- Price
- $54.8
- Updated
- 2024/03/01
- Product number
- A1001
- Product name
- Methyl 3-Aminocrotonate
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $16
- Updated
- 2024/03/01
- Product number
- A1001
- Product name
- Methyl 3-Aminocrotonate
- Purity
- >98.0%(T)
- Packaging
- 500g
- Price
- $90
- Updated
- 2024/03/01
- Product number
- B24953
- Product name
- Methyl 3-aminocrotonate, 97%
- Packaging
- 500g
- Price
- $95.3
- Updated
- 2024/03/01
Methyl 3-aminocrotonate Chemical Properties,Usage,Production
Chemical Properties
Crystals, yellowish-white
Uses
Methyl 3-aminocrotonate is used as intermediate for the syntheses of pharmaceuticals (e.g. 1,4-dihydropyridine derivatives) as well as for the manufacture of stabilizers and plastics. Product Data Sheet
Uses
Methyl 3-aminocrotonate (Methyl 3-amino-2-butenoate) was used to synthesize 4-aryl-1,4-dihydropyridines possessing potential calcium channel blocking activity.
Uses
Nitrendipine (N490150) metabolite. The pharmacokinetics of Nitrendipine was studied in the rat and 6 major metabolites were identified.
Application
Methyl 3-aminocrotonate reacts with benzene to form the corresponding E-2-phenyliodonio tosylate in good yield. This new alkenyl iodonium salt upon reaction with various nucleophiles offers an easy access to substituted enamine derivatives of crotonic acid. The reaction can be also extended to N-substituted crotonates[1].
Preparation
3-Aminocrotonate Esters, e.g., methyl 3- aminocrotonate [14205-39-1] (3-amino-2-butenoic acid, methyl ester) can be prepared by treatment of acetoacetates with aqueous ammonia. They are mainly used in the production of a series of the dihydropyridine-type calcium antagonists.
General Description
Methyl 3-aminocrotonate undergoes waste-free solid-state cascade reaction with crystalline ninhydrin.
Flammability and Explosibility
Not classified
References
[1] IOANNIS PAPOUTSIS; Anastasios V ?; Spyros Spyroudis ?. Reactivity of a new alkenyl phenyliodonium tosylate derived from methyl 3-aminocrotonate[J]. Tetrahedron, 1998. DOI:10.1016/S0040-4020(97)10354-4.
Methyl 3-aminocrotonate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 3-aminocrotonate Suppliers
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View Lastest Price from Methyl 3-aminocrotonate manufacturers
- Product
- Methyl 3-aminocrotonate 14205-39-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-27
- Product
- Methyl 3-aminocrotonate 14205-39-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2 ton
- Release date
- 2024-09-05
- Product
- Methyl 3-aminocrotonate 14205-39-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-04-15