ChemicalBook > CAS DataBase List > Methyl 3-aminocrotonate

Methyl 3-aminocrotonate

Product Name
Methyl 3-aminocrotonate
CAS No.
14205-39-1
Chemical Name
Methyl 3-aminocrotonate
Synonyms
Methyl (Z)-3-Aminobut-2-enoate;3-Aminocrotonate;(Z)-Methyl 3-aMinobut-2-enoate;methyl (E)-3-aminobut-2-enoate;3-Amino-but-2-enoic acid methyl ester;PALO-012;Nifedipine-4;Methyl 3-aminocroton;Nifedipine Impurity 5;Methyl 3-aminocrotote
CBNumber
CB2222855
Molecular Formula
C5H9NO2
Formula Weight
115.13
MOL File
14205-39-1.mol
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Methyl 3-aminocrotonate Property

Melting point:
81-83 °C(lit.)
Boiling point:
112°C 42mm
Density 
1.1808 (rough estimate)
vapor pressure 
2.79-2.853hPa at 25℃
refractive index 
1.4538 (estimate)
Flash point:
91 °C
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
18g/l
form 
Crystalline Powder
pka
5.27±0.70(Predicted)
color 
White to slightly yellow
PH
8-9 (18g/l, H2O, 20℃)
Water Solubility 
insoluble
Sensitive 
Hygroscopic
BRN 
956592
InChIKey
XKORCTIIRYKLLG-ONEGZZNKSA-N
LogP
-0.27 at 25℃
CAS DataBase Reference
14205-39-1(CAS DataBase Reference)
EPA Substance Registry System
2-Butenoic acid, 3-amino-, methyl ester (14205-39-1)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
37/39-26-24/25
WGK Germany 
3
RTECS 
EM9092500
TSCA 
Yes
HS Code 
29224995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
129712
Product name
Methyl 3-aminocrotonate
Purity
97%
Packaging
100g
Price
$54.6
Updated
2024/03/01
Sigma-Aldrich
Product number
129712
Product name
Methyl 3-aminocrotonate
Purity
97%
Packaging
500g
Price
$54.8
Updated
2024/03/01
TCI Chemical
Product number
A1001
Product name
Methyl 3-Aminocrotonate
Purity
>98.0%(T)
Packaging
25g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
A1001
Product name
Methyl 3-Aminocrotonate
Purity
>98.0%(T)
Packaging
500g
Price
$90
Updated
2024/03/01
Alfa Aesar
Product number
B24953
Product name
Methyl 3-aminocrotonate, 97%
Packaging
500g
Price
$95.3
Updated
2024/03/01
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Methyl 3-aminocrotonate Chemical Properties,Usage,Production

Chemical Properties

Crystals, yellowish-white

Uses

Methyl 3-aminocrotonate is used as intermediate for the syntheses of pharmaceuticals (e.g. 1,4-dihydropyridine derivatives) as well as for the manufacture of stabilizers and plastics. Product Data Sheet

Uses

Methyl 3-aminocrotonate (Methyl 3-amino-2-butenoate) was used to synthesize 4-aryl-1,4-dihydropyridines possessing potential calcium channel blocking activity.

Uses

Nitrendipine (N490150) metabolite. The pharmacokinetics of Nitrendipine was studied in the rat and 6 major metabolites were identified.

Preparation

3-Aminocrotonate Esters, e.g., methyl 3- aminocrotonate [14205-39-1] (3-amino-2-butenoic acid, methyl ester) can be prepared by treatment of acetoacetates with aqueous ammonia. They are mainly used in the production of a series of the dihydropyridine-type calcium antagonists.

General Description

Methyl 3-aminocrotonate undergoes waste-free solid-state cascade reaction with crystalline ninhydrin.

Flammability and Explosibility

Not classified

Methyl 3-aminocrotonate Preparation Products And Raw materials

Raw materials

Preparation Products

Benidipine Cilnidipine Isradipine Nitrendipine Felodipine Manidipine Nisoldipine Amlodipine
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Methyl 3-aminocrotonate Suppliers

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View Lastest Price from Methyl 3-aminocrotonate manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Methyl 3-aminocrotonate 14205-39-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000kg
Release date
2024-04-15
Hebei Mojin Biotechnology Co., Ltd
Product
Methyl 3-aminocrotonate 14205-39-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-04
Hebei Guanlang Biotechnology Co., Ltd.
Product
Methyl 3-aminocrotonate 14205-39-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-08-18

14205-39-1, Methyl 3-aminocrotonateRelated Search:

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