Isradipine

Product Name: Isradipine
CAS No.: 75695-93-1
Chemical Name: Isradipine
Synonyms: Iomir;Lomir;Presca;CS-139;Prescal;Esradin;Rebfiden;Clivoten;DynaCirc;Dynacrine
CBNumber: CB2268682
Molecular Formula: C19H21N3O5
Formula Weight: 371.39
MOL File: 75695-93-1.mol

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Isradipine Property

Melting point:: 166-1680C
Boiling point:: 501.9±60.0 °C(Predicted)
Density: 1.249±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ~26 mg/mL
form: solid
pka: 2.56±0.70(Predicted)
color: yellow
Merck: 14,5240
BCS Class: 2/4
Stability:: Stable for 2 years from date of purchsae as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey: HMJIYCCIJYRONP-UHFFFAOYSA-N
CAS DataBase Reference: 75695-93-1(CAS DataBase Reference)
NIST Chemistry Reference: Isradipine(75695-93-1)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2934990002

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H413May cause long lasting harmful effects to aquatic life
Precautionary statements: P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I6658
Product name: Isradipine
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $212
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.08507
Product name: Isradipine - CAS 75695-93-1 - Calbiochem
Purity: A voltage gated calcium channel gating inhibitor of the dihydropyridine class.
Packaging: 10MG
Price: $142
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1354207
Product name: Isradipine
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $375
Updated: 2024/03/01

TCI Chemical

Product number: I0876
Product name: Isradipine
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $157
Updated: 2024/03/01

Alfa Aesar

Product number: J63920
Product name: Isradipine, 98+%
Packaging: 10mg
Price: $117.65
Updated: 2024/03/01

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Isradipine Chemical Properties,Usage,Production

Description

Isradipine is a long-acting calcium blocker effective in the treatment of essential hypertension. The advantages of isradipine as compared with other dihydropyridine calcium antagonists include a "gentle" onset and fewer contraindications. It can be taken by patients with diabetes mellitus, chronic obstructive airway diseases, gout, congestive heart failure or ischemic heart disease.

Chemical Properties

Yellow Solid

Originator

Sandoz (Switzerland)

Uses

Isradipine is a L-type calcium channel blocker, Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.

Uses

nonsedating H1-antihistamine

Uses

Dihydropyridine calcium channel blocker. Antihypertensive; antianginal

Definition

ChEBI: Isradipine is an isopropyl ester, a methyl ester, a dihydropyridine and a benzoxadiazole.

brand name

Dynacirc (Reliant);Prescal.

General Description

Isradipine, 4-(4-benzofuranazyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester (DynaCirc), is another second-generationdihydropyridine-type channel blocker. This drug, like theother second-generation analogs, is more selective for vascularsmooth muscle than for myocardial tissue. It is effectivein the treatment of stable angina, reducing the frequencyof anginal attacks and the need to use nitroglycerin.

Biological Activity

Potent and selective L-type voltage-gated Ca 2+ channel blocker. EC 50 and pA 2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca 2+ -induced contractions of rabbit aorta respectively; EC 25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo , exerting primary effects on vascular tissue with secondary negative chronotropic action.

Biochem/physiol Actions

L-type calcium channel blocker (also referred to as dihydropyridine-type calcium channel blocker); antihypertensive.

storage

Room temperature

References

1) Bracht et al. (2001), Isradipine improves endothelium-dependent vasodilation in normotensive coronary artery disease patients with hypercholesterolemia; J. Hyperten., 19 899 2) Chandra et al. (1999), Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia ; Pharmacology, 58 292 3) Merck 14:5240

Isradipine Preparation Products And Raw materials

Raw materials

Isopropyl acetoacetate Benzofuroxan Methyl 3-aminocrotonate

Preparation Products

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Isradipine Suppliers

Americas 1 Canada 5 China 164 Europe 3 France 4 Germany 2 India 24 Italy 2 Japan 1 Malaysia 1 Mexico 1 Nepal 1 Poland 1 South Korea 1 Spain 1 Sweden 2 Switzerland 2 United Kingdom 13 United States 44 Global 273

Shanghai Junye chemical Co., Ltd

Tel: 021-021-50318666 18516602538
Fax: +86-21-61924293
Email: shlip@163.com
Country: China
ProdList: 58
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

Ascent Scientific

Tel: 4401179829988
Fax: 4402030 700 369
Email: customerservice@ascentscientific.co.uk
Country: United Kingdom
ProdList: 279
Advantage: 60

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10194
Advantage: 62

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

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View Lastest Price from Isradipine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Isradipine 75695-93-1
Price: US $0.00/G
Min. Order: 1G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-08

Baoji Guokang Healthchem co.,ltd

Product: Isradipine 75695-93-1
Price: US $158.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 1000kg
Release date: 2021-06-08

Dideu Industries Group Limited

Product: Isradipine 75695-93-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-06

75695-93-1, IsradipineRelated Search:

N,N-Dimethylformamide Dimethyl ether Dimethyl fumarate Dimethyl phthalate Dimethyl sebacate Dimethyl sulfoxide Dihydromyrcenol Dimethyl carbonate ETHANE Pranidipine Ebselen Bendamustine Lercanidipine Oxiracetam Elacridar Isradipine Impurity 2（Isradipine EP Impurity B） Benzofuroxan 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID

PN-200-110

Presca

Prescal

4-(4-Benzofurazanyl)-2，6-dimethyl-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl 1-methylethyl ester

4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic [chemical name] acid methyl 1-methylethyl ester

Dynacrine

Iomir

Rebfiden

3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester

4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-isopropyl ester

PN-200-100

[R,(-)]-4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester

Isradipine

CS-139

(4R)-4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-propan-2-yl ester

Dynacirc CR

PN 200-110;DYNACIRC; LOMIR; PRESCAL; DYNACIRC CR;

Isradipin

Clivoten

DynaCirc

Esradin

Isrodipine

Lomir

Isradipine Solution, 100ppm

4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylicacidmethyl1-methylethylester

Isradipine (200 mg)

3-Methyl 5-propan-2-yl (4R)-4-(2,1,3-benzoxadiazol-4-yl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate

Isradipine(Dynacirc)

Isradipine API

4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester

Isradipine, >=99%

3-Isopropyl 5-methyl 4-(benzo[c][1,2,5]oxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-di

4-(4-BENZOFURAZANYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 1-METHYLETHYL ESTER

4-(2,1,3-BENZOXADIAZOL-4-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINECARBOXYLIC ACID METHYL 1-METHYLETHYL ESTER

Isradipine&gt

Isradipine CRS

3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3-methyl 5-(1-methylethyl) ester

4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Isopropyl Methyl Ester

Isopropyl Methyl 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimet

Isopropyl Methyl 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

Isradipine USP/EP/BP

Isradipine (PN 200-110)

IsradipineQ: What is Isradipine Q: What is the CAS Number of Isradipine Q: What is the storage condition of Isradipine Q: What are the applications of Isradipine

4-(4-BChemicalbookenzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic[chemicalname]acidmethyl1-methylethylester

Isradipine (1354207)

Isopropyl methyl(±)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

75695-93-1

75696-93-1

75695-63-1

C19H15N3O5D6

ALLEGRA

Ion Channels

Calcium channel

Intermediates & Fine Chemicals

Pharmaceuticals

API