Isradipine
- Product Name
- Isradipine
- CAS No.
- 75695-93-1
- Chemical Name
- Isradipine
- Synonyms
- Iomir;Lomir;Presca;CS-139;Prescal;Esradin;Rebfiden;Clivoten;DynaCirc;Dynacrine
- CBNumber
- CB2268682
- Molecular Formula
- C19H21N3O5
- Formula Weight
- 371.39
- MOL File
- 75695-93-1.mol
Isradipine Property
- Melting point:
- 166-1680C
- Boiling point:
- 501.9±60.0 °C(Predicted)
- Density
- 1.249±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ~26 mg/mL
- form
- solid
- pka
- 2.56±0.70(Predicted)
- color
- yellow
- Merck
- 14,5240
- BCS Class
- 2/4
- Stability:
- Stable for 2 years from date of purchsae as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChIKey
- HMJIYCCIJYRONP-UHFFFAOYSA-N
- CAS DataBase Reference
- 75695-93-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Isradipine(75695-93-1)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 2934990002
N-Bromosuccinimide Price
- Product number
- I6658
- Product name
- Isradipine
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $212
- Updated
- 2024/03/01
- Product number
- 5.08507
- Product name
- Isradipine - CAS 75695-93-1 - Calbiochem
- Purity
- A voltage gated calcium channel gating inhibitor of the dihydropyridine class.
- Packaging
- 10MG
- Price
- $142
- Updated
- 2024/03/01
- Product number
- 1354207
- Product name
- Isradipine
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $375
- Updated
- 2024/03/01
- Product number
- I0876
- Product name
- Isradipine
- Purity
- >98.0%(HPLC)
- Packaging
- 25mg
- Price
- $157
- Updated
- 2024/03/01
- Product number
- J63920
- Product name
- Isradipine, 98+%
- Packaging
- 10mg
- Price
- $117.65
- Updated
- 2024/03/01
Isradipine Chemical Properties,Usage,Production
Description
Isradipine is a long-acting calcium blocker effective in the treatment of essential hypertension. The advantages of isradipine as compared with other dihydropyridine calcium antagonists include a "gentle" onset and fewer contraindications. It can be taken by patients with diabetes mellitus, chronic obstructive airway diseases, gout, congestive heart failure or ischemic heart disease.
Chemical Properties
Yellow Solid
Originator
Sandoz (Switzerland)
Uses
Isradipine is a L-type calcium channel blocker, Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.
Uses
nonsedating H1-antihistamine
Uses
Dihydropyridine calcium channel blocker. Antihypertensive; antianginal
Definition
ChEBI: Isradipine is an isopropyl ester, a methyl ester, a dihydropyridine and a benzoxadiazole.
brand name
Dynacirc (Reliant);Prescal.
General Description
Isradipine, 4-(4-benzofuranazyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester (DynaCirc), is another second-generationdihydropyridine-type channel blocker. This drug, like theother second-generation analogs, is more selective for vascularsmooth muscle than for myocardial tissue. It is effectivein the treatment of stable angina, reducing the frequencyof anginal attacks and the need to use nitroglycerin.
Biological Activity
Potent and selective L-type voltage-gated Ca 2+ channel blocker. EC 50 and pA 2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca 2+ -induced contractions of rabbit aorta respectively; EC 25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo , exerting primary effects on vascular tissue with secondary negative chronotropic action.
Biochem/physiol Actions
L-type calcium channel blocker (also referred to as dihydropyridine-type calcium channel blocker); antihypertensive.
storage
Room temperature
References
1) Bracht et al. (2001), Isradipine improves endothelium-dependent vasodilation in normotensive coronary artery disease patients with hypercholesterolemia; J. Hyperten., 19 899 2) Chandra et al. (1999), Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia ; Pharmacology, 58 292 3) Merck 14:5240
Isradipine Preparation Products And Raw materials
Raw materials
Preparation Products
Isradipine Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23680
- Advantage
- 75
View Lastest Price from Isradipine manufacturers
- Product
- Isradipine 75695-93-1
- Price
- US $0.00/G
- Min. Order
- 1G
- Purity
- 98%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-08
- Product
- Isradipine 75695-93-1
- Price
- US $158.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2021-06-08
- Product
- Isradipine 75695-93-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09