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Lercanidipine

Product Name
Lercanidipine
CAS No.
100427-26-7
Chemical Name
Lercanidipine
Synonyms
Rec-15-2375;Masnidipine;LERCANIDIPINE;Lercanadipine;Lercanidipine 13C-d3;LercanidipineC36H41N306;Lercanidipine USP/EP/BP;LERCANIDIPINE(FORR&DONLY);methyl [2-(3,3-diphenylpropyl-methyl-amino)-1,1-dimethyl-ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;LercanidipineQ: What is Lercanidipine Q: What is the CAS Number of Lercanidipine Q: What is the storage condition of Lercanidipine
CBNumber
CB4133658
Molecular Formula
C36H41N3O6
Formula Weight
611.73
MOL File
100427-26-7.mol
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Lercanidipine Property

Melting point:
118-120°C
Boiling point:
712.5±60.0 °C(Predicted)
Density 
1.177±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
8.66±0.50(Predicted)
color 
Light yellow to yellow
CAS DataBase Reference
100427-26-7(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B3483
Product name
Lercanidipine
Packaging
10mg
Price
$87
Updated
2021/12/16
AK Scientific
Product number
M617
Product name
Lercanidipine
Packaging
25mg
Price
$98
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003147
Product name
LERCANIDIPINE
Purity
95.00%
Packaging
25MG
Price
$252
Updated
2021/12/16
AK Scientific
Product number
M617
Product name
Lercanidipine
Packaging
100mg
Price
$279
Updated
2021/12/16
ApexBio Technology
Product number
B3483
Product name
Lercanidipine
Packaging
50mg
Price
$308
Updated
2021/12/16
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Lercanidipine Chemical Properties,Usage,Production

Description

Lerdip was launched in the Netherlands for hypertension. It is prepared in four steps, the last of which is a Hantsch reaction of 1-[(3,3-diphenyl)-N-methylpropylamino]- 2-methyl-2-propyl-2-(3-nitrobenzylidene)acetoacetate with methyl 3-aminocrotonate. This compound was designed to be very lipophilic which imparts the drug with a gradual onset and a long duration of action as a result of prolonged exposure to receptors by partitioning into membranes. It is an antagonist of L-type calcium channels with no activity in smooth muscle cells, is tissue selective, lacks any myocardial contractility impairment, has no neuroendocrine activation, and has negligible affinity for neurotransmitter receptors such as α1- and α2-adrenergic receptors. While sold as a racemate, the calcium channel activity is found in the (S)- isomer with the (R)-isomer being 2-orders of magnitude less active. It has an increased cardiac contractility index which is much more than Nitrendipine or nifedipine. The good selectivity causes a reduction in blood pressure with no negative inotropic effects.

Originator

Recordati (Italy)

Uses

Antihypertensive compound; calcium channel blocker.

Definition

ChEBI: Lercanidipine is a diarylmethane.

brand name

Cardiovasc (Recor dati, Italy); Carmen (Recordati, Italy); Corifeo (Recordati, Italy); Lercadip (Recordati, Italy); Lercan (Recordati, Italy); Lercapin (Recordati, Italy); Lercaton (Recordati, Italy); Lerkamen (Recordati, Italy); Lerzam (Recordati, Italy); Renovia (Recordati, Italy); Vasodip (Recordati, Italy); Zandip (Recordati, Italy); Zanicor (Recordati, Italy).

Lercanidipine Preparation Products And Raw materials

Raw materials

Preparation Products

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Lercanidipine Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8844
Advantage
52
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Shanghai Sphchem Co., Ltd.
Tel
21-21-56491756 13512199871
Fax
021-5649-1756
Email
sales@panhongchem.com
Country
China
ProdList
3999
Advantage
55
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
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View Lastest Price from Lercanidipine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Lercanidipine 100427-26-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Lercanidipine 100427-26-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Shaanxi Dideu Medichem Co. Ltd
Product
Lercanidipine 100427-26-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-11

100427-26-7, LercanidipineRelated Search:


  • LERCANIDIPINE
  • 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITTROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-[(3,3-DIPHENYLPROPYL)METHYLAMINO]-1,1-DIMETHYLETHYL METHYL ESTER
  • methyl [2-(3,3-diphenylpropyl-methyl-amino)-1,1-dimethyl-ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • 5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • LercanidipineC36H41N306
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl]5-methyl ester
  • 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-[1,1-dimethyl-2-[methyl(3,3-diphenylpropyl)amino]ethyl] ester
  • Masnidipine
  • Rec-15-2375
  • LERCANIDIPINE(FORR&DONLY)
  • Lercanidipine 13C-d3
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester
  • Lercanadipine
  • Lercanidipine USP/EP/BP
  • LercanidipineQ: What is Lercanidipine Q: What is the CAS Number of Lercanidipine Q: What is the storage condition of Lercanidipine
  • 100427-26-7
  • 100472-26-7
  • 132566-11-6
  • C36H41N3O6
  • Inhibitors
  • inhibitor