Lercanidipine
- Product Name
- Lercanidipine
- CAS No.
- 100427-26-7
- Chemical Name
- Lercanidipine
- Synonyms
- Rec-15-2375;Masnidipine;LERCANIDIPINE;Lercanadipine;Lercanidipine 13C-d3;LercanidipineC36H41N306;Lercanidipine USP/EP/BP;LERCANIDIPINE(FORR&DONLY);methyl [2-(3,3-diphenylpropyl-methyl-amino)-1,1-dimethyl-ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;LercanidipineQ: What is Lercanidipine Q: What is the CAS Number of Lercanidipine Q: What is the storage condition of Lercanidipine
- CBNumber
- CB4133658
- Molecular Formula
- C36H41N3O6
- Formula Weight
- 611.73
- MOL File
- 100427-26-7.mol
Lercanidipine Property
- Melting point:
- 118-120°C
- Boiling point:
- 712.5±60.0 °C(Predicted)
- Density
- 1.177±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 8.66±0.50(Predicted)
- CAS DataBase Reference
- 100427-26-7(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- B3483
- Product name
- Lercanidipine
- Packaging
- 10mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- M617
- Product name
- Lercanidipine
- Packaging
- 25mg
- Price
- $98
- Updated
- 2021/12/16
- Product number
- API0003147
- Product name
- LERCANIDIPINE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $252
- Updated
- 2021/12/16
- Product number
- M617
- Product name
- Lercanidipine
- Packaging
- 100mg
- Price
- $279
- Updated
- 2021/12/16
- Product number
- B3483
- Product name
- Lercanidipine
- Packaging
- 50mg
- Price
- $308
- Updated
- 2021/12/16
Lercanidipine Chemical Properties,Usage,Production
Description
Lerdip was launched in the Netherlands for hypertension. It is prepared in four steps, the last of which is a Hantsch reaction of 1-[(3,3-diphenyl)-N-methylpropylamino]- 2-methyl-2-propyl-2-(3-nitrobenzylidene)acetoacetate with methyl 3-aminocrotonate. This compound was designed to be very lipophilic which imparts the drug with a gradual onset and a long duration of action as a result of prolonged exposure to receptors by partitioning into membranes. It is an antagonist of L-type calcium channels with no activity in smooth muscle cells, is tissue selective, lacks any myocardial contractility impairment, has no neuroendocrine activation, and has negligible affinity for neurotransmitter receptors such as α1- and α2-adrenergic receptors. While sold as a racemate, the calcium channel activity is found in the (S)- isomer with the (R)-isomer being 2-orders of magnitude less active. It has an increased cardiac contractility index which is much more than Nitrendipine or nifedipine. The good selectivity causes a reduction in blood pressure with no negative inotropic effects.
Originator
Recordati (Italy)
Uses
Antihypertensive compound; calcium channel blocker.
Definition
ChEBI: Lercanidipine is a diarylmethane.
brand name
Cardiovasc (Recor dati, Italy); Carmen (Recordati, Italy); Corifeo (Recordati, Italy); Lercadip (Recordati, Italy); Lercan (Recordati, Italy); Lercapin (Recordati, Italy); Lercaton (Recordati, Italy); Lerkamen (Recordati, Italy); Lerzam (Recordati, Italy); Renovia (Recordati, Italy); Vasodip (Recordati, Italy); Zandip (Recordati, Italy); Zanicor (Recordati, Italy).
Lercanidipine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Lercanidipine manufacturers
- Product
- Lercanidipine 100427-26-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-06
- Product
- Lercanidipine 100427-26-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Lercanidipine 100427-26-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09