Lercanidipine

ChemicalBook > CAS DataBase List > Lercanidipine

Product Name: Lercanidipine
CAS No.: 100427-26-7
Chemical Name: Lercanidipine
Synonyms: Rec-15-2375;Masnidipine;LERCANIDIPINE;Lercanadipine;Lercanidipine 13C-d3;LercanidipineC36H41N306;Lercanidipine USP/EP/BP;LERCANIDIPINE(FORR&DONLY);Lercanidipine, 10 mM in DMSO;methyl [2-(3,3-diphenylpropyl-methyl-amino)-1,1-dimethyl-ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CBNumber: CB4133658
Molecular Formula: C36H41N3O6
Formula Weight: 611.73
MOL File: 100427-26-7.mol

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Lercanidipine Property

Melting point:: 118-120°C
Boiling point:: 712.5±60.0 °C(Predicted)
Density: 1.177±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 8.66±0.50(Predicted)
color: Light yellow to yellow
CAS DataBase Reference: 100427-26-7(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B3483
Product name: Lercanidipine
Packaging: 10mg
Price: $87
Updated: 2021/12/16

AK Scientific

Product number: M617
Product name: Lercanidipine
Packaging: 25mg
Price: $98
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003147
Product name: LERCANIDIPINE
Purity: 95.00%
Packaging: 25MG
Price: $252
Updated: 2021/12/16

AK Scientific

Product number: M617
Product name: Lercanidipine
Packaging: 100mg
Price: $279
Updated: 2021/12/16

ApexBio Technology

Product number: B3483
Product name: Lercanidipine
Packaging: 50mg
Price: $308
Updated: 2021/12/16

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Lercanidipine Chemical Properties,Usage,Production

Description

Lerdip was launched in the Netherlands for hypertension. It is prepared in four steps, the last of which is a Hantsch reaction of 1-[(3,3-diphenyl)-N-methylpropylamino]- 2-methyl-2-propyl-2-(3-nitrobenzylidene)acetoacetate with methyl 3-aminocrotonate. This compound was designed to be very lipophilic which imparts the drug with a gradual onset and a long duration of action as a result of prolonged exposure to receptors by partitioning into membranes. It is an antagonist of L-type calcium channels with no activity in smooth muscle cells, is tissue selective, lacks any myocardial contractility impairment, has no neuroendocrine activation, and has negligible affinity for neurotransmitter receptors such as α₁- and α₂-adrenergic receptors. While sold as a racemate, the calcium channel activity is found in the (S)- isomer with the (R)-isomer being 2-orders of magnitude less active. It has an increased cardiac contractility index which is much more than Nitrendipine or nifedipine. The good selectivity causes a reduction in blood pressure with no negative inotropic effects.

Originator

Recordati (Italy)

Uses

Antihypertensive compound; calcium channel blocker.

Definition

ChEBI: Lercanidipine is a diarylmethane.

brand name

Cardiovasc (Recor dati, Italy); Carmen (Recordati, Italy); Corifeo (Recordati, Italy); Lercadip (Recordati, Italy); Lercan (Recordati, Italy); Lercapin (Recordati, Italy); Lercaton (Recordati, Italy); Lerkamen (Recordati, Italy); Lerzam (Recordati, Italy); Renovia (Recordati, Italy); Vasodip (Recordati, Italy); Zandip (Recordati, Italy); Zanicor (Recordati, Italy).

Lercanidipine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Lercanidipine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Lercanidipine 100427-26-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Lercanidipine 100427-26-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Shaanxi Dideu Medichem Co. Ltd

Product: Lercanidipine 100427-26-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-11

100427-26-7, LercanidipineRelated Search:

Dimethyl sulfate Dimethyl carbonate Dimethyl ether Dacthal ETHANE 2,6-Lutidine Dimethyl sulfoxide Dimethyl disulfide Chlorodimethylphenylsilane Dimethyl fumarate Poly(dimethylsiloxane) 2,5-PYRIDINEDICARBOXYLIC ACID N,N-Dimethylformamide N-Ethylmethylamine Quinolinic acid Nitrendipine tert-Butyl methacrylate Lercanidipine mainring

LERCANIDIPINE

1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITTROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-[(3,3-DIPHENYLPROPYL)METHYLAMINO]-1,1-DIMETHYLETHYL METHYL ESTER

methyl [2-(3,3-diphenylpropyl-methyl-amino)-1,1-dimethyl-ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

LercanidipineC36H41N306

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl]5-methyl ester

2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-[1,1-dimethyl-2-[methyl(3,3-diphenylpropyl)amino]ethyl] ester

Masnidipine

Rec-15-2375

LERCANIDIPINE(FORR&DONLY)

Lercanidipine 13C-d3

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester

Lercanadipine

Lercanidipine USP/EP/BP

LercanidipineQ: What is Lercanidipine Q: What is the CAS Number of Lercanidipine Q: What is the storage condition of Lercanidipine

Lercanidipine, 10 mM in DMSO

100427-26-7

100472-26-7

132566-11-6

C36H41N3O6

Inhibitors

inhibitor