Indications and Usage Mechanisms of Action Pharmacokinetics Clinical Research
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Oxiracetam

Indications and Usage Mechanisms of Action Pharmacokinetics Clinical Research
Product Name
Oxiracetam
CAS No.
62613-82-5
Chemical Name
Oxiracetam
Synonyms
4-hydroxy-2-oxo-1-pyrrolidineacetamid;2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide;ct-848;isf2522;Neurome;Olaxitam;Olacetam;Neuractiv;CGP 21690;oxiraceta
CBNumber
CB3328242
Molecular Formula
C6H10N2O3
Formula Weight
158.16
MOL File
62613-82-5.mol
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Oxiracetam Property

Melting point:
165-168 °C
Boiling point:
494.6±40.0 °C(Predicted)
Density 
1.416
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form 
Solid
pka
13.76±0.20(Predicted)
color 
White to Off-White
Merck 
14,6942
InChI
InChI=1S/C6H10N2O3/c7-5(10)3-8-2-4(9)1-6(8)11/h4,9H,1-3H2,(H2,7,10)
InChIKey
IHLAQQPQKRMGSS-UHFFFAOYSA-N
SMILES
N1(CC(N)=O)CC(O)CC1=O
CAS DataBase Reference
62613-82-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
UX9656638
HS Code 
2933.79.8500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical
Product number
O0398
Product name
Oxiracetam
Purity
>96.0%(GC)(N)
Packaging
1g
Price
$89
Updated
2024/03/01
TCI Chemical
Product number
O0398
Product name
Oxiracetam
Purity
>96.0%(GC)(N)
Packaging
5g
Price
$300
Updated
2024/03/01
TRC
Product number
O846905
Product name
Oxiracetam
Packaging
1g
Price
$120
Updated
2021/12/16
ApexBio Technology
Product number
B4748
Product name
Oxiracetam
Packaging
100mg
Price
$280
Updated
2021/12/16
ChemScene
Product number
CS-8012
Product name
Oxiracetam
Purity
99.76%
Packaging
100mg
Price
$280
Updated
2021/12/16
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Oxiracetam Chemical Properties,Usage,Production

Indications and Usage

Oxiracetam is a more potent derivative of the nootropic drug piracetam. They were developed in 1974 by the Italian company ICF and went on sale in 1987. Oxiracetam is a Piracetam derivative and excites the central nervous system, promotes brain metabolism, significantly increases and promotes memory retention, and effectively treats senile memory and mental decline. It is used to treat brain dysfunction psychiatric syndrome and mental disorders. It can improve the memory and learning abilities of patients with senile dementia or memory disorders. It is suitable for treating neural dysfunction, memory disorder and intelligence disorders caused by brain damage. It can also be used as a recovery treatment for neurosis, brain trauma, encephalitis, and other brain diseases. Oxiracetam’s greatest advantage is that it is very soluble in water, making it suitable for injection. Research shows that Oxiracetam has higher pharmacological activity and significant curative effects compared to Piracetam.

Mechanisms of Action

Oxiracetam’s mechanisms of action are similar to those of Piracetam. It promotes the binding of phosphorylcholine and phosphoethanolamine, increases the ratio of ATP/ADP in the brain, and increases the binding of protein with nucleic acids in the brain, thus improving the memory and learning ability of patients with senile dementia and memory disorder.

Pharmacokinetics

After intake, most of the drug will not accumulate in the body and will be excreted through urine in its original form. It is well-absorbed and well-tolerated.

Clinical Research

Animal trials showed that in all types of behavioral experiments, Oxiracetam can improve memory retention and learning ability, reduce brain shocks’ damage on memory, and prevent the learning abilities of rats suffering from spontaneous hypertensive cerebrovascular injury from decreasing. It can also increase acetylcholine circulation in rats’ skin and hippocampus, thus increasing affinity for choline uptake.

Description

Oxiracetam is a structural analogue of piracetam. This compound has enhancing effects on vigilance and memory. In comparison with piracetam, oxiracetam exhibits greater improvement in memory (Itil et al., 1986) and has been used extensively for the treatment of dementia, including AD, VaD, MID (Baumel et al., 1989; Dysken et al., 1989), and mixed forms. Green et al. (1992) failed to demonstrate a difference from placebo in AD patients. In contrast, Maina et al. (1989) studied 289 patients with MID in a double-blind placebo-controlled trial and after 12 weeks of treatment found that oxiracetam reduced behavioural symptoms.

Chemical Properties

Whie Solid

Originator

ISF (Italy)

Uses

Oxiracetam is a 4-hydroxy analog of piracetam with psychostimulant activity, reportedly useful in relieving the symptoms of cerebral insufficiency in the elderly.

Definition

ChEBI: Oxiracetam is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid.

brand name

Neuromet

Biochem/physiol Actions

Nootropic agent, improves learning and memory, and prevents impairment of cognitive functions. Its mechanism of action in not yet known, but it is suggested to modulate glutamatergic and cholinergic neurotransmission. Protein kinase C may be involved.

Purification Methods

This nootropic (Alzheimer) drug is purified by recrystallisation from MeOH or aqueous Me2CO and dried in vacuo. [NMR, IR: Pifferi & Pinza Farmaco Ed Sci 32 602 1977, Banfi et al. Farmaco Ed Sci 39 16 1984, Gouilaev & Senning Brain Research Rev 19 180 1994.]

Oxiracetam Preparation Products And Raw materials

Raw materials

Preparation Products

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Oxiracetam Suppliers

Jinan Xuanzheng Pharmaceutical Co. LTD
Tel
18610218799
Email
xuanzhengyaoye@126.com
Country
China
ProdList
14
Advantage
58
Shaanxi Pioneer Biotech Co., Ltd.
Tel
13720616393;029-84385017-8003 13720616393
Fax
029-84385017
Email
sales@pioneerbiotech.com
Country
China
ProdList
1063
Advantage
56
Jinan Sanyuan Chemical Co. LTD
Tel
0531-58582194 13335164090
Fax
0531-58585914
Email
1660423085@qq.com
Country
China
ProdList
406
Advantage
58
Heng Sheng Jiu He meditech Co.,Ltd
Tel
18766988138
Email
411863413@qq.com
Country
China
ProdList
122
Advantage
58
Wuhan Yida Pharmaceutical Co., Ltd
Tel
+86-13401188533 +86-13476102740
Email
3451936732@qq.com
Country
China
ProdList
26
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
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View Lastest Price from Oxiracetam manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Oxiracetam 62613-82-5
Price
US $1000.00-400.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-12
Wuhan Nutra Biotechnology Co.,Ltd
Product
oxiracetam 62613-82-5
Price
US $0.00-0.00/g
Min. Order
100g
Purity
98%
Supply Ability
1000kgs
Release date
2021-05-23
Hebei Dangtong Import and export Co LTD
Product
Oxiracetam 62613-82-5
Price
US $1.80-1.40/Grams
Min. Order
150Grams
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-17

62613-82-5, OxiracetamRelated Search:


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