Oxiracetam

ChemicalBook > CAS DataBase List > Oxiracetam

Indications and Usage Mechanisms of Action Pharmacokinetics Clinical Research

Product Name: Oxiracetam
CAS No.: 62613-82-5
Chemical Name: Oxiracetam
Synonyms: 4-hydroxy-2-oxo-1-pyrrolidineacetamid;2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide;ct-848;isf2522;Neurome;Olaxitam;Neuractiv;CGP 21690;oxiraceta;xiracetam
CBNumber: CB3328242
Molecular Formula: C6H10N2O3
Formula Weight: 158.16
MOL File: 62613-82-5.mol

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Oxiracetam Property

Melting point:: 165-168 °C
Boiling point:: 494.6±40.0 °C(Predicted)
Density: 1.416
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form: Solid
pka: 13.76±0.20(Predicted)
color: White to Off-White
Merck: 14,6942
InChI: InChI=1S/C6H10N2O3/c7-5(10)3-8-2-4(9)1-6(8)11/h4,9H,1-3H2,(H2,7,10)
InChIKey: IHLAQQPQKRMGSS-UHFFFAOYSA-N
SMILES: N1(CC(N)=O)CC(O)CC1=O
CAS DataBase Reference: 62613-82-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: UX9656638
HS Code: 2933.79.8500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical

Product number: O0398
Product name: Oxiracetam
Purity: >96.0%(GC)(N)
Packaging: 1g
Price: $89
Updated: 2024/03/01

TCI Chemical

Product number: O0398
Product name: Oxiracetam
Purity: >96.0%(GC)(N)
Packaging: 5g
Price: $300
Updated: 2024/03/01

TRC

Product number: O846905
Product name: Oxiracetam
Packaging: 1g
Price: $120
Updated: 2021/12/16

ApexBio Technology

Product number: B4748
Product name: Oxiracetam
Packaging: 100mg
Price: $280
Updated: 2021/12/16

ChemScene

Product number: CS-8012
Product name: Oxiracetam
Purity: 99.76%
Packaging: 100mg
Price: $280
Updated: 2021/12/16

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Oxiracetam Chemical Properties,Usage,Production

Indications and Usage

Oxiracetam is a more potent derivative of the nootropic drug piracetam. They were developed in 1974 by the Italian company ICF and went on sale in 1987. Oxiracetam is a Piracetam derivative and excites the central nervous system, promotes brain metabolism, significantly increases and promotes memory retention, and effectively treats senile memory and mental decline. It is used to treat brain dysfunction psychiatric syndrome and mental disorders. It can improve the memory and learning abilities of patients with senile dementia or memory disorders. It is suitable for treating neural dysfunction, memory disorder and intelligence disorders caused by brain damage. It can also be used as a recovery treatment for neurosis, brain trauma, encephalitis, and other brain diseases. Oxiracetam’s greatest advantage is that it is very soluble in water, making it suitable for injection. Research shows that Oxiracetam has higher pharmacological activity and significant curative effects compared to Piracetam.

Mechanisms of Action

Oxiracetam’s mechanisms of action are similar to those of Piracetam. It promotes the binding of phosphorylcholine and phosphoethanolamine, increases the ratio of ATP/ADP in the brain, and increases the binding of protein with nucleic acids in the brain, thus improving the memory and learning ability of patients with senile dementia and memory disorder.

Pharmacokinetics

After intake, most of the drug will not accumulate in the body and will be excreted through urine in its original form. It is well-absorbed and well-tolerated.

Clinical Research

Animal trials showed that in all types of behavioral experiments, Oxiracetam can improve memory retention and learning ability, reduce brain shocks’ damage on memory, and prevent the learning abilities of rats suffering from spontaneous hypertensive cerebrovascular injury from decreasing. It can also increase acetylcholine circulation in rats’ skin and hippocampus, thus increasing affinity for choline uptake.

Description

Oxiracetam is a structural analogue of piracetam. This compound has enhancing effects on vigilance and memory. In comparison with piracetam, oxiracetam exhibits greater improvement in memory (Itil et al., 1986) and has been used extensively for the treatment of dementia, including AD, VaD, MID (Baumel et al., 1989; Dysken et al., 1989), and mixed forms. Green et al. (1992) failed to demonstrate a difference from placebo in AD patients. In contrast, Maina et al. (1989) studied 289 patients with MID in a double-blind placebo-controlled trial and after 12 weeks of treatment found that oxiracetam reduced behavioural symptoms.

Chemical Properties

Whie Solid

Originator

ISF (Italy)

Uses

Oxiracetam is a 4-hydroxy analog of piracetam with psychostimulant activity, reportedly useful in relieving the symptoms of cerebral insufficiency in the elderly.

Definition

ChEBI: Oxiracetam is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid.

brand name

Neuromet

Biochem/physiol Actions

Nootropic agent, improves learning and memory, and prevents impairment of cognitive functions. Its mechanism of action in not yet known, but it is suggested to modulate glutamatergic and cholinergic neurotransmission. Protein kinase C may be involved.

Purification Methods

This nootropic (Alzheimer) drug is purified by recrystallisation from MeOH or aqueous Me2CO and dried in vacuo. [NMR, IR: Pifferi & Pinza Farmaco Ed Sci 32 602 1977, Banfi et al. Farmaco Ed Sci 39 16 1984, Gouilaev & Senning Brain Research Rev 19 180 1994.]

Oxiracetam Preparation Products And Raw materials

Raw materials

Silica glass Ethyl 2-bromopropionate Ethanol Anhydrous benzene 1,1-Dimethoxyethane Dichloromethane ETHYL PYRROLIDINOACETATE

Preparation Products

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Oxiracetam Suppliers

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View Lastest Price from Oxiracetam manufacturers

Wuhan Cell Pharmaceutical Co., Ltd

Product: Oxiracetam 62613-82-5
Price: US $150.00-125.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2023-04-11

Hebei Dangtong Import and export Co LTD

Product: Oxiracetam 62613-82-5
Price: US $1.80-1.40/Grams
Min. Order: 150Grams
Purity: 99.99%
Supply Ability: 100Tons
Release date: 2023-03-17

Shanghai Affida new material science and technology center

Product: Oxiracetam 62613-82-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 10 tons
Release date: 2024-05-08

62613-82-5, OxiracetamRelated Search:

Piracetam Oxiracetam 4-hydroxypyrrolidin-2-one (S)-4-Hydroxy-2-pyrrolidinone oxiracetaM related substance ISF3886 Omeprazole Mecobalamin Pramiracetam Aniracetam Nefiracetam ILOPERIDONE Paliperidone 2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)acetaMide methyl 4-hydroxy-2-oxopyrrolidine-1-acetate 2-[(carbamoylmethyl)amino]acetamide 4-Hydroxy-2-oxo-1-pyrrolidineacetic acid (4S)-4-hydroxy-2-oxo-1-Pyrrolidineacetic acid Methyl ester ethyl 4-hydroxy-2-oxopyrrolidine-1-acetate

4-HYDROXY-2-OXOPYRROLIDINE-N-ACETAMIDE

4-hydroxy-2-oxo-1-pyrrolidineacetamid

4-hydroxy-2-oxo-1-pyrrolidineacetamide

4-hydroxypiracetam

ct-848

hydroxypiracetam

Oxiracetam, >=99%

2-(4-HYDROXY-PYRROLIDINO-2-ON-1-YL)ETHYL ACETATE

4-1-lydroxypiracetan

Oxiracetam 99.7%

isf2522

OXIRACETAM

Oxriacetam

2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide

Neuractiv

Neurome

OXIRACETAM; ISF2522;

CGP 21690

CGP 21690E

(S)-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetaMide

oxiraceta

-HYDROXY-2-OXOPYRROLIDINE-N-ACETAMIDE

Oxiracetam(Random Configuration)

(88929-35-5) oxiracetam

Oxiracetam Oxiracetam

Oxiracetam&gt

2-(4-Hydroxy-2-oxo-1-pyrrolidinyl)acetamide

Oxiracetam USP/EP/BP

xiracetam

4-hydroxy-2-oxo-1-

TIANFU-CHEM CAS:62613-82-5 4-Hydroxy-2-oxopyrrolidine-N-acetamide

-Amino-2-methyl-311H-tetrazole

Olaxitam

Oxiracetam, ≥ 95.0%

62613-82-5

62613-82-8

pharmaceutical intermediate

Amines

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Brain health drug

Nootropic

Pharmaceutical material and intermeidates

APIs

API

(intermediate of oxiracetam)

62613-82-5