(S)-4-Hydroxy-2-pyrrolidinone

Product Name: (S)-4-Hydroxy-2-pyrrolidinone
CAS No.: 68108-18-9
Chemical Name: (S)-4-Hydroxy-2-pyrrolidinone
Synonyms: SHPD;OxiracetaM iMpurity A;Oxiracetam Impurity 9;Oxiracetam impurity H;Oxiracetam Impurity N;Busulfan Impurity1706;Oxiracetam impurities1718;4-HYDROXY-PYRROLIDIN-2-ONE;(S)-4-HYDROXY-2-PYRROLIDONE;(s)-β-hydroxy-γ-butyrolactam
CBNumber: CB1474345
Molecular Formula: C4H7NO2
Formula Weight: 101.1
MOL File: 68108-18-9.mol

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(S)-4-Hydroxy-2-pyrrolidinone Property

Melting point:: 156-159 °C (lit.)
alpha: -41 º (c=% in ethanol)
Boiling point:: 363.6±35.0 °C(Predicted)
Density: 1.292±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
Water Solubility: Slightly soluble in water
pka: 13.62±0.20(Predicted)
form: Solid
color: White to off-white
optical activity: [α]23/D 43°, c = 1 in ethanol
BRN: 1524192
InChI: 1S/C4H7NO2/c6-3-1-4(7)5-2-3/h3,6H,1-2H2,(H,5,7)/t3-/m0/s1
InChIKey: IOGISYQVOGVIEU-VKHMYHEASA-N
SMILES: O[C@@H]1CNC(=O)C1
CAS DataBase Reference: 68108-18-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 22-24/25-36-26
WGK Germany: 3
HS Code: 29349990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Eye Dam. 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 479179
Product name: (S)-(?)-4-Hydroxy-2-pyrrolidinone
Purity: 97%
Packaging: 5g
Price: $221
Updated: 2025/07/31

Sigma-Aldrich

Product number: 479179
Product name: (S)-(?)-4-Hydroxy-2-pyrrolidinone
Purity: 97%
Packaging: 1g
Price: $52.5
Updated: 2023/06/20

TCI Chemical

Product number: H1368
Product name: (S)-(-)-4-Hydroxy-2-pyrrolidone
Purity: >98.0%(GC)
Packaging: 1g
Price: $203
Updated: 2025/07/31

TRC

Product number: H953075
Product name: (S)-(-)-4-Hydroxy-2-pyrrolidinone
Packaging: 10g
Price: $1055
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0001929
Product name: (S)-4-HYDROXY-2-PYRROLIDINONE
Purity: 95.00%
Packaging: 10G
Price: $2148.3
Updated: 2021/12/16

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(S)-4-Hydroxy-2-pyrrolidinone Chemical Properties,Usage,Production

Chemical Properties

White crystal

Uses

(S)-(?)-4-Hydroxy-2-pyrrolidinone can be used as a starting material in the preparation of:

Biologically significant pyrrolo[1,2:1′,2′]azepino[5,6-b]indole derivatives.
Substituted azepanes by reacting with various aldehydes via photochemical [5+2] cycloaddition.

Uses

The (S)-enantiomer intermediate in the preparation of Oxiracetam

General Description

4-Hydroxy-2-pyrrolidinone is an important building block found in many bioactive compounds like streptopyrrolidine. It can be used as an intermediate in the synthesis of various γ-amino acids (GABA) and substituted 2-pyrrolidinones like cynometrine and cynodine.

Synthesis

10.1 g (100 mmol) of 2-oxiranylacetamide, CuI 0.95 g (5 mmol), cesium carbonate 2 g (200 mmol) was added to 150 ml of ammonia in a saturated solution of methanol, 55 ?? for stirring reaction for 8 h, the reaction solution was concentrated under reduced pressure, 100 ml of water was added, dichloromethane extraction three times, saturated saline washed three times, the phase of ethyl acetate was concentrated under reduced pressure, and petroleum ether recrystallization to obtain (S)-(-)-4-hydroxy-2-pyrrolidinone 8.71g, yield 86.3%, HPLC purity 99.42% (area normalization method), ee value 99.67%.

(S)-4-Hydroxy-2-pyrrolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-4-Hydroxy-2-pyrrolidinone Suppliers

Americas 1 Canada 2 China 182 Europe 1 France 1 Germany 5 India 13 Japan 4 South Korea 3 Switzerland 2 United Kingdom 14 United States 44 Global 272

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View Lastest Price from (S)-4-Hydroxy-2-pyrrolidinone manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (S)-4-Hydroxy-2-pyrrolidinone 68108-18-9
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-24

R&D Scientific Inc.

Product: 4-Hydroxy-2-pyrrolidone 68108-18-9
Price: US $2800.00/Kg
Min. Order: 1Kg
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-05-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: (S)-4-Hydroxy-2-pyrrolidinone 68108-18-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

68108-18-9, (S)-4-Hydroxy-2-pyrrolidinoneRelated Search:

N-Vinyl-2-pyrrolidone CHLOROPHOSPHONAZO III 2-Pyrrolidinone N-Methyl-2-pyrrolidone Povidone iodine 4-hydroxypyrrolidin-2-one OxiracetaM Related CoMpound 2 Oxiracetam Related Compound 7 Oxiracetam 2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)acetaMide Oxiracetam Related Compound 8 methyl 4-hydroxy-2-oxopyrrolidine-1-acetate 2-[(carbamoylmethyl)amino]acetamide Oxiracetam Related Compound 5 4-Hydroxy-2-oxo-1-pyrrolidineacetic acid (4S)-4-hydroxy-2-oxo-1-Pyrrolidineacetic acid Methyl ester Polyvinylpyrrolidone ethyl 4-hydroxy-2-oxopyrrolidine-1-acetate

2-PYRROLIDINONE, 4-HYDROXY-, (S)

2-PYRROLIDINONE, 4-HYDROXY-, (4S)-

(4S)-4-HYDROXYPYRROLIDIN-2-ONE

4-HYDROXY-PYRROLIDIN-2-ONE

(s)-(-)-β-hydroxy-γ-butyrolactam

(s)-β-hydroxy-γ-butyrolactam

(S)-(-)-4-HYDROXY-2-PYRROLIDINONE

(S)-(+)-4-HYDROXY-2-PYRROLIDINONE

(S)-4-HYDROXY-2-PYRROLIDINONE

(S)-4-HYDROXY-2-PYRROLIDONE

(S)-4-HYDROXY-PYRROLIDINE-2-ONE

SHPD

(S)-BETA-HYDROXY-GAMMA-BUTYROLACTAM

(S)-(-)-4-Hydroxy-2-pyrrolinone

(4S)-4-hydroxy-2-pyrrolidone

(S)-4-Hydroxy-pyrrolidin-2-one

(4S)-(-)-4-Hydroxy-2-oxopyrrolidine, (4S)-(-)-beta-Hydroxy-gamma-butyrolactam

(4S)-4-Hydroxy-2-pyrrolidinone

OxiracetaM iMpurity A

Oxiracetam Impurity 9

(S)-4-Mercapto-2-pyrrolidone

Oxiracetam Impurity A ((S)-4-Hydroxy-2-pyrrolidinone)

(S)-(-)-4-Hydroxy-2-pyrrolidinone 97%

(S)-4-Hydroxy-2-pyrrolidone,99%e.e.

Oxiracetam impurity H

Oxiracetam Impurity N

(S)-(-)-4-Hydroxy-2-pyrrolidone&gt

Busulfan Impurity1706

Oxiracetam impurities1718

(S)-(-)-4-Hydroxy-2-pyrrolidinone (Oxiracetam Impurity)

(<i>S</i>)-(?)-4-Hydroxy-2-pyrrolidinone

(S)-4-hydroxypyrrolidin-2-one, 98%min

68108-18-9

C4H7NO2

Heterocyclic Building Blocks

Pyrrolidines

Chiral Building Blocks

Asymmetric Synthesis

Amines

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Chiral

Pyrrolidinone derivatives

Drug Intermediates