Nefiracetam

Product Name: Nefiracetam
CAS No.: 77191-36-7
Chemical Name: Nefiracetam
Synonyms: DMMPA;dmppa;dm9384;DZL-221;Translon;NEFIRACETAM;Nefiracetam>Nefiracetam powder;Nefiracetam (DM9384;Racetam Nefiracetam
CBNumber: CB2416333
Molecular Formula: C14H18N2O2
Formula Weight: 246.3
MOL File: 77191-36-7.mol

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Nefiracetam Property

Melting point:: 151-155°C
Boiling point:: 458.5±33.0 °C(Predicted)
Density: 1.187±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: >5mg/mL
pka: 13.77±0.70(Predicted)
form: solid
color: white to off-white
Merck: 14,6439
InChI: InChI=1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)
InChIKey: NGHTXZCKLWZPGK-UHFFFAOYSA-N
SMILES: N1(CC(NC2=C(C)C=CC=C2C)=O)CCCC1=O
CAS DataBase Reference: 77191-36-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: UX9655650
HS Code: 2933.79.1500
Toxicity: LD50 in mice (mg/kg): 421 i.v.; 1766 orally (Betzing, 1982)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N2288
Product name: Nefiracetam
Purity: solid
Packaging: 50mg
Price: $201
Updated: 2024/03/01

Sigma-Aldrich

Product number: N2288
Product name: Nefiracetam
Purity: solid
Packaging: 250mg
Price: $738
Updated: 2024/03/01

TCI Chemical

Product number: N0996
Product name: Nefiracetam
Purity: >98.0%(N)
Packaging: 200mg
Price: $125
Updated: 2024/03/01

TCI Chemical

Product number: N0996
Product name: Nefiracetam
Purity: >98.0%(N)
Packaging: 1g
Price: $497
Updated: 2024/03/01

Tocris

Product number: 2851
Product name: Nefiracetam
Purity: ≥99%(HPLC)
Packaging: 100
Price: $156
Updated: 2021/12/16

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Nefiracetam Chemical Properties,Usage,Production

Uses

analgesic, antiinflammatory

Uses

Nefiracetam improves post-ischemia evoke-nonconvulsive seizure by altering pro-inflammatory cytokines.

Definition

ChEBI: Nefiracetam is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid.

Biological Activity

Cognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo .

Mechanism of action

The mechanisms of nefiracetam seem to be linked back to two pathways. One of these pathways prolongs the opening of calcium channels (tied into PKA and a Gi/o protein), which enhances the signalling of a receptor independent of the synapse. The other pathway seems to be tied into PKC and CAMKII, which then augments signalling through cholinergic receptors (which then releases most excitatory neurotransmitters from the presynaptic level, like nicotine). The former pathway (calcium channels) appears critical for long-term potentiation, whereas the latter pathway (PKC/CAMKII) appears vital for neuronal signal enhancement. Some other minor pathways include being a partial agonist at the glycine binding site of the NDMA receptor (may enhance signalling when there are subpar levels of glycine but attenuates excessive signalling) and increasing affinity of the muscarinic acetylcholine receptors for its ligand, acetylcholine.

storage

Store at RT

Nefiracetam Preparation Products And Raw materials

Raw materials

Pyrrolidone 2,6-Dimethylaniline

Preparation Products

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Nefiracetam Suppliers

Americas 1 Belgium 1 China 250 Europe 3 Germany 1 India 2 Japan 1 Switzerland 1 United Kingdom 5 United States 32 Global 297

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8835
Advantage: 52

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 9387
Advantage: 52

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2859
Advantage: 58

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4940
Advantage: 60

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

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View Lastest Price from Nefiracetam manufacturers

Jinan Jianfeng Chemical Co., Ltd

Product: Nefiracetam 77191-36-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20ton
Release date: 2024-08-13

Shandong Huizhihan Supply Chain Co., Ltd

Product: Nefiracetam 77191-36-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 2000
Release date: 2024-12-11

Hebei Mujin Biotechnology Co.,Ltd

Product: Nefiracetam 77191-36-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2024-03-01

77191-36-7, NefiracetamRelated Search:

N,N-Dimethylacetamide Citalopram Gabapentin Pramiracetam Aniracetam Oxiracetam Nefiracetam N-Methyl-2-pyrrolidone Polyvinylpyrrolidone Pyrrolidine Piracetam Pyrrocaine Lidocaine Pyrrole MONOETHYLGLYCINEXYLIDIDE 1-(2-aminoethyl)pyrrolidin-2-one N-(2-METHYLPHENYL)-2-(PROPYLAMINO)ACETAMIDE 1-[2-OXO-2-(4,4,6-TRIMETHYL-1-THIOXO-1,4-DIHYDRO-5H-[1,2]DITHIOLO[3,4-C]QUINOLIN-5-YL)ETHYL]PYRROLIDINE-2,5-DIONE

n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamide

NEFIRACETAM

2-oxo-1-pyrrolidinylaceticacid,2,6-dimethylanilide

dm9384

dmppa

n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamid

DM-9384, (2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide)

DMMPA

DZL-221

Translon

2',6'-Dimethyl-2-(2-oxo-1-pyrrolidinyl)acetoanilide

N-(2,6-Dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide

(2-(2-oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide)

NefiracetaM(Translon)

1-PyrrolidineacetaMide,N-(2,6-diMethylphenyl)-2-oxo-

N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide

Nefiracetam powder

Nefiracetam/C14H18N2O2

Nefiracetam&gt

Nefiracetam USP/EP/BP

Nefiracetam (DM9384

Racetam Nefiracetam

TIANFU-CHEM_ Nefiracetam

Nai the west temple

Nefiracetam in methanol

Nefiracetam, 10 mM in DMSO

77191-36-7

77161-36-7

Pharmaceutical intermediate

TRANSLON

Nootropic

Smart drug

BDO

API