2,6-Dimethylaniline
- Product Name
- 2,6-Dimethylaniline
- CAS No.
- 87-62-7
- Chemical Name
- 2,6-Dimethylaniline
- Synonyms
- 2,6-XYLIDINE;2,6-Dimethylbenzenamine;xylylamine;2,6-Xylidin;2,6-dimethylphenylamine;2,6-Dimethyl-phenylamine;2,6-DMA;NSC 7098;ai3-52358;NCI-C56188
- CBNumber
- CB8327518
- Molecular Formula
- C8H11N
- Formula Weight
- 121.18
- MOL File
- 87-62-7.mol
2,6-Dimethylaniline Property
- Melting point:
- 10-12 °C(lit.)
- Boiling point:
- 216 °C
- Density
- 0.984 g/mL at 25 °C(lit.)
- vapor pressure
- <0.01 mm Hg ( 20 °C)
- refractive index
- n20/D 1.560(lit.)
- Flash point:
- 196 °F
- storage temp.
- Store below +30°C.
- solubility
- 13g/l
- form
- Liquid
- pka
- 3.89(at 25℃)
- color
- Clear yellow to red-brown
- PH
- 12.5 (100g/l, H2O, 20℃)
- PH Range
- 12.5
- explosive limit
- 1.3-6.9%(V)
- Water Solubility
- 7.5 g/L (20 ºC)
- Merck
- 14,10084
- BRN
- 636332
- Stability:
- Air Sensitive, Hygroscopic
- LogP
- 1.840
- CAS DataBase Reference
- 87-62-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzenamine, 2,6-dimethyl-(87-62-7)
- IARC
- 2B (Vol. 57) 1993
- EPA Substance Registry System
- 2,6-Xylidine (87-62-7)
Safety
- Hazard Codes
- Xn,N,T
- Risk Statements
- 20/21/22-37/38-40-51/53
- Safety Statements
- 23-25-36/37-61
- RIDADR
- UN 1711 6.1/PG 2
- WGK Germany
- 2
- RTECS
- ZE9275000
- F
- 8
- Autoignition Temperature
- 490 °C
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29214910
- Hazardous Substances Data
- 87-62-7(Hazardous Substances Data)
- Toxicity
- LD50 orally in Rabbit: 1290 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H335May cause respiratory irritation
H351Suspected of causing cancer
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- D146005
- Product name
- 2,6-Dimethylaniline
- Purity
- 99%
- Packaging
- 5g
- Price
- $47.7
- Updated
- 2024/03/01
- Product number
- 8.08671
- Product name
- 2,6-Dimethylaniline
- Purity
- for synthesis
- Packaging
- 5ml
- Price
- $26.7
- Updated
- 2024/03/01
- Product number
- 8.08671
- Product name
- 2,6-Dimethylaniline
- Purity
- for synthesis
- Packaging
- 250ML
- Price
- $45.3
- Updated
- 2024/03/01
- Product number
- 8.08671
- Product name
- 2,6-Dimethylaniline
- Purity
- for synthesis
- Packaging
- 1L
- Price
- $145
- Updated
- 2024/03/01
- Product number
- 442327
- Product name
- 2,6-Dimethylaniline
- Purity
- analytical standard
- Packaging
- 1000mg
- Price
- $20.7
- Updated
- 2024/03/01
2,6-Dimethylaniline Chemical Properties,Usage,Production
Chemical Properties
clear yellow to red-brown liquid
Uses
2,6-Dimethylaniline is used in pharmaceuticals, as dye intermediates and in organic synthesis. It is also used in the production of antioxidants, agricultural, pharmaceutical, rubber chemicals and other target organic molecules.
Uses
Bupivacaine (B689560) impurity.
Preparation
2,6-Dimethylaninile is prepared by nitration of xylene and reduction, followed by removal of the 2,4-isomer by formation of the acetate salt, removal of the 2,5-isomer by formation of the hydrochloride salt, and recovery of the 2,6-isomer by sublimation (US National Library of Medicine, 1992a).
2,6-Dimethylaniline is produced by one company each in Japan, Switzerland and the USA and by three companies in Germany (Chemical Information Servces, 1991).
Definition
ChEBI: 2,6-dimethylaniline is a primary arylamine that is aniline in which the hydrogens at the 2- and 6-positions are replaced by methyl groups. It is used in the production of some anasthetics and other chemicals. It is a drug metabolite of lidocaine (local anasthetic). It has a role as a carcinogenic agent and a drug metabolite. It is a primary arylamine and a dimethylaniline.
Synthesis Reference(s)
Journal of the American Chemical Society, 92, p. 7464, 1970 DOI: 10.1021/ja00728a038
The Journal of Organic Chemistry, 37, p. 3570, 1972
General Description
A liquid. Toxic by ingestion, inhalation and skin absorption. Slightly soluble in water. Used in pharmaceuticals, as dye intermediates and organic syntheses.
Air & Water Reactions
Slightly soluble in water.
Reactivity Profile
2,6-Dimethylaniline reacts with strong oxidizing agents [Handling Chemicals Safely 1980 p. 964]. Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard
May be fatal if inhaled, swallowed or absorbed through skin. Vapor or mist irritating to the eyes, mucous membranes and upper respiratory tract; causes skin irritation. Absorption into body leads to the formation of methemoglobin which, in sufficient concentration, may cause cyanosis. Onset may be delayed 2-4 hours or longer. Exposure can cause nausea, dizziness, headache, damage to the eyes, and blood effects.
Fire Hazard
Special Hazards of Combustion Products: Container explosion may occur under fire conditions. Emits toxic fumes under fire conditions.
Safety Profile
Suspected carcinogen. Moderately toxic by ingestion. Mutation data reported. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits toxic fumes of NOx. See also other xylidme entries.
Purification Methods
Convert vic-xylidine to a derivative (see below) which, after recrystallisation, is decomposed with alkali to give the free base. Dry it over KOH and fractionally distil. The acetyl derivative has m 177o, the benzoyl derivative has m 168o, and the picrate has m 180o. [Beilstein 12 H 1107, 12 IV 2521.]
2,6-Dimethylaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Dimethylaniline manufacturers
- Product
- 2,6-Dimethylaniline 87-62-7
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 2000mt/year
- Release date
- 2021-11-05
- Product
- 2,6-Dimethylaniline 87-62-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-12-04
- Product
- 2,6-Dimethylaniline 87-62-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100tons
- Release date
- 2023-09-22