ChemicalBook > CAS DataBase List > 2,6-Dimethylaniline

2,6-Dimethylaniline

Product Name
2,6-Dimethylaniline
CAS No.
87-62-7
Chemical Name
2,6-Dimethylaniline
Synonyms
2,6-XYLIDINE;2,6-Dimethylbenzenamine;xylylamine;2,6-Xylidin;2,6-dimethylphenylamine;2,6-Dimethyl-phenylamine;2,6-DMA;NSC 7098;ai3-52358;NCI-C56188
CBNumber
CB8327518
Molecular Formula
C8H11N
Formula Weight
121.18
MOL File
87-62-7.mol
More
Less

2,6-Dimethylaniline Property

Melting point:
10-12 °C(lit.)
Boiling point:
216 °C
Density 
0.984 g/mL at 25 °C(lit.)
vapor pressure 
<0.01 mm Hg ( 20 °C)
refractive index 
n20/D 1.560(lit.)
Flash point:
196 °F
storage temp. 
Store below +30°C.
solubility 
13g/l
form 
Liquid
pka
3.89(at 25℃)
color 
Clear yellow to red-brown
PH Range
12.5
PH
12.5 (100g/l, H2O, 20℃)
explosive limit
1.3-6.9%(V)
Water Solubility 
7.5 g/L (20 ºC)
Merck 
14,10084
BRN 
636332
Stability:
Air Sensitive, Hygroscopic
LogP
1.840
CAS DataBase Reference
87-62-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 2,6-dimethyl-(87-62-7)
IARC
2B (Vol. 57) 1993
EPA Substance Registry System
2,6-Xylidine (87-62-7)
More
Less

Safety

Hazard Codes 
Xn,N,T
Risk Statements 
20/21/22-37/38-40-51/53
Safety Statements 
23-25-36/37-61
RIDADR 
UN 1711 6.1/PG 2
WGK Germany 
2
RTECS 
ZE9275000
F 
8
Autoignition Temperature
490 °C
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29214910
Hazardous Substances Data
87-62-7(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 1290 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H335May cause respiratory irritation

H351Suspected of causing cancer

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D146005
Product name
2,6-Dimethylaniline
Purity
99%
Packaging
5g
Price
$47.7
Updated
2024/03/01
Sigma-Aldrich
Product number
8.08671
Product name
2,6-Dimethylaniline
Purity
for synthesis
Packaging
5ml
Price
$26.7
Updated
2024/03/01
Sigma-Aldrich
Product number
8.08671
Product name
2,6-Dimethylaniline
Purity
for synthesis
Packaging
250ML
Price
$45.3
Updated
2024/03/01
Sigma-Aldrich
Product number
8.08671
Product name
2,6-Dimethylaniline
Purity
for synthesis
Packaging
1L
Price
$145
Updated
2024/03/01
Sigma-Aldrich
Product number
442327
Product name
2,6-Dimethylaniline
Purity
analytical standard
Packaging
1000mg
Price
$20.7
Updated
2024/03/01
More
Less

2,6-Dimethylaniline Chemical Properties,Usage,Production

Chemical Properties

clear yellow to red-brown liquid

Uses

2,6-Dimethylaniline is used in pharmaceuticals, as dye intermediates and in organic synthesis. It is also used in the production of antioxidants, agricultural, pharmaceutical, rubber chemicals and other target organic molecules.

Uses

Bupivacaine (B689560) impurity.

Preparation

2,6-Dimethylaninile is prepared by nitration of xylene and reduction, followed by removal of the 2,4-isomer by formation of the acetate salt, removal of the 2,5-isomer by formation of the hydrochloride salt, and recovery of the 2,6-isomer by sublimation (US National Library of Medicine, 1992a).
2,6-Dimethylaniline is produced by one company each in Japan, Switzerland and the USA and by three companies in Germany (Chemical Information Servces, 1991).

Definition

ChEBI: 2,6-dimethylaniline is a primary arylamine that is aniline in which the hydrogens at the 2- and 6-positions are replaced by methyl groups. It is used in the production of some anasthetics and other chemicals. It is a drug metabolite of lidocaine (local anasthetic). It has a role as a carcinogenic agent and a drug metabolite. It is a primary arylamine and a dimethylaniline.

Synthesis Reference(s)

Journal of the American Chemical Society, 92, p. 7464, 1970 DOI: 10.1021/ja00728a038
The Journal of Organic Chemistry, 37, p. 3570, 1972

General Description

A liquid. Toxic by ingestion, inhalation and skin absorption. Slightly soluble in water. Used in pharmaceuticals, as dye intermediates and organic syntheses.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

2,6-Dimethylaniline reacts with strong oxidizing agents [Handling Chemicals Safely 1980 p. 964]. Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

May be fatal if inhaled, swallowed or absorbed through skin. Vapor or mist irritating to the eyes, mucous membranes and upper respiratory tract; causes skin irritation. Absorption into body leads to the formation of methemoglobin which, in sufficient concentration, may cause cyanosis. Onset may be delayed 2-4 hours or longer. Exposure can cause nausea, dizziness, headache, damage to the eyes, and blood effects.

Fire Hazard

Special Hazards of Combustion Products: Container explosion may occur under fire conditions. Emits toxic fumes under fire conditions.

Safety Profile

Suspected carcinogen. Moderately toxic by ingestion. Mutation data reported. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits toxic fumes of NOx. See also other xylidme entries.

Purification Methods

Convert vic-xylidine to a derivative (see below) which, after recrystallisation, is decomposed with alkali to give the free base. Dry it over KOH and fractionally distil. The acetyl derivative has m 177o, the benzoyl derivative has m 168o, and the picrate has m 180o. [Beilstein 12 H 1107, 12 IV 2521.]

2,6-Dimethylaniline Preparation Products And Raw materials

Raw materials

N-Methylaniline 2,6-Dimethylphenol 2,6-Dimethyl-1-nitrobenzene m-Xylene Nitrification o-Toluidine 2,4-Dimethyl aniline Dilute hydrochloric acid CYCLOXYDIM

Preparation Products

N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)IMINODIACETIC ACID 2',6'-DIMETHYLACETANILIDE Nefiracetam Alachlor PILSICAINIDE Metazachlor Ropivacaine Bupivacaine Metalaxyl (2,6-DIMETHYL-PHENYL)-HYDRAZINE 2,6-Dimethylbenzyl alcohol Tetramethylbenzidine Oxadixyl Benalaxyl 1-(2,6-DIMETHYLPHENYL)PIPERAZINE
More
Less

2,6-Dimethylaniline Suppliers

Americas 1 Belgium 4 Canada 2 China 336 Europe 4 France 2 Germany 16 India 65 Japan 8 Singapore 1 Slovakia 1 South Korea 1 Switzerland 2 Ukraine 2 United Kingdom 16 United States 67 Global 528
-Hebei DaPeng Pharm & Chem Co., Ltd.
Tel
0317-7238109 18653455825
Fax
0317-7238109
Email
sales@dpchem.com
Country
China
ProdList
2
Advantage
58
Shandong Hongyuan Chemical Technology Co., LTD
Tel
13561560789
Email
xinxiaoxiao2008@126.com
Country
China
ProdList
511
Advantage
58
Shanghai Aoguang Biotechnology Co., Ltd
Tel
1735-4997695 17715859063
Email
1204996172@qq.com
Country
China
ProdList
246
Advantage
58
Wuhan Xinyang Ruihe Chemical Technology Co., Ltd.
Tel
13720181483 13720181483
Email
366443693@QQ.COM
Country
China
ProdList
5047
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9413
Advantage
66
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shanghai G&K Biomedical Scientific Inc.
Tel
021-34502253 13391330186
Fax
+86-21-23027826
Email
info@gksci.com
Country
China
ProdList
133
Advantage
52
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Aemon Chemical
Tel
0086-755-86198205
Email
acinfo@aemonchem.com
Country
China
ProdList
1931
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Springchem New Material Technology Co.,Limited
Tel
+86-021-62885108 +8613917661608
Email
info@spring-chem.com
Country
China
ProdList
2068
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
TaiZhou ZhiCheng Chemicals & Technology Co., LTD.
Tel
0523-82837785 13914525028
Fax
0523-87913272
Email
info@jszchg.com
Country
China
ProdList
249
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
86(512)5235 8471 17715136450
Fax
86(512)5235 6881
Email
sales@shiyabiopharm.com
Country
China
ProdList
4169
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
Wuxi Zhangkun Biochemical Technology Co., Ltd.
Tel
+86 0510-85629785
Fax
+86 0510-85625359
Country
China
ProdList
2327
Advantage
58
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3930
Advantage
58
Beijing Universal Century Technology Co., Ltd.
Tel
400-8706899
Fax
400-8706899
Email
hysj_bj.com
Country
China
ProdList
3583
Advantage
55
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3120
Advantage
55
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4924
Advantage
55
TianJin Alta Scientific Co., Ltd.
Tel
022-65378550-8551
Fax
+86-022-2532-9655
Email
contact@altascientific.com
Country
China
ProdList
2773
Advantage
58
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Country
China
ProdList
2930
Advantage
58
RiZhao LiDeShi Chemical Co., Ltd.
Tel
010-51268198
Fax
010-63833209
Email
leadershipchem@126.com
Country
China
ProdList
2546
Advantage
58
Mei Lan Industrial (Shanghai) Co., Ltd.
Tel
021-58958189
Fax
021-58957967
Email
wouchina@126.com
Country
China
ProdList
2666
Advantage
55
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9346
Advantage
58
More
Less

View Lastest Price from 2,6-Dimethylaniline manufacturers

Jinan Finer Chemical Co., Ltd
Product
2,6-Dimethylaniline 87-62-7
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
2000mt/year
Release date
2021-11-05
Hebei Yanxi Chemical Co., Ltd.
Product
2,6-Dimethylaniline 87-62-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
100tons
Release date
2023-09-22
Hebei Chuanghai Biotechnology Co,.LTD
Product
2,6-Dimethylaniline 87-62-7
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-15

87-62-7, 2,6-DimethylanilineRelated Search:

Diphenylamine Poly(dimethylsiloxane) 2,6-Lutidine Dimethyl sulfoxide Metformin N,N-Dimethylaniline Dimethyl carbonate N,N-Dimethylacetamide N,N-Dimethylformamide ALTRENOGEST DIMETHYLANILINE Dibutyl phthalate Dimethyl fumarate Dimethyl sulfate Glycine Betaine Dimethylamine p-Amino-N,N-dimethylaniline

  • 2,6-Xylidine, 2-Amino-m-xylene
  • 2,6-Dimethylaniline Solution, 100ppm
  • 2,6-two Methyl aniline
  • 2.6-DiMethylan
  • ai3-52358
  • Aniline, 2,6-dimethyl-
  • NCI-C56188
  • 2,6-Dimethylaniline (Lidocaine RCA)
  • AKOS BBS-00003564
  • 1-Amino-2,6-dimethylbenzene
  • 2,6-dimethyl-anilin
  • DIMETHYLANILINE,2,6-
  • TIMTEC-BB SBB008136
  • VIC-M-XYLIDINE
  • xylylamine
  • 6-Amino-m-xylene
  • 2,6-XYLIDINE
  • 2,6-DIMETHYLANILINE
  • 2-AMINO-1,3-DIMETHYLBENZENE
  • 2-AMINO-M-XYLENE
  • LABOTEST-BB LTBB000551
  • 2,6-DIMETHYLANILINE, 1ML, NEAT
  • 2,6-DIMETHYLANILINE, 1000MG, NEAT
  • 2,6-DIMETHYLANILINE PESTANAL
  • Lidocaine Related Compound A
  • 2,6-Xylidine (NH2=1)
  • Benzenamine, 2,6-dimethyl-
  • amino-p-xylol
  • 2,6-DIMETHYLBENZAMINE
  • 2,6-Xylidine, 2-Amino-1,3-dimethylbenzene
  • 2,6-xylidine 2,6-dimethylaniline
  • 2,6-DIMETHYLANILINE pure
  • 2,6-Xylidine, 2-Amino-1,3-dimethylbenzene, 2-Amino-m-xylene
  • 2,6-dimethyl-benzenamin
  • 2,6-Dimethylbenzenamine
  • 2,6-dimethyl-Benzenamine
  • 2,6-Dimethylbenzeneamine
  • 2,6-dimethylphenylamine
  • 2,6-Dimethyl-phenylamine
  • 2,6-DMA
  • 2,6-Xyildine
  • 2,6-Xylylamine
  • 2-amino-1,3-dimethyl-benzen
  • 2-Amino-1,3-xylene
  • 2,6XylidinePure
  • 2,6-Xylidine99%
  • 2,6-Dimethylaniline,99%
  • 2.6-Dimethylaniline 5g [87-62-7]
  • 2,6-Dimethylaniline,2,6-Xylidine, 2-Amino-1,3-dimethylbenzene, 2-Amino-m-xylene
  • Aniline Salts
  • 2,6-DiMethylaniline, 99% 100GR
  • 2,6-DiMethylaniline, 99% 500GR
  • 2,6-DiMethylaniline, 99% 5GR
  • NSC 7098
  • 2,6-DIMETHYLANILINE FOR SYNTHESIS
  • 2,6-Dimethylaniline &gt
  • 2,6-DimethylanilineSolution,100mg/L,5x1ml
  • 2,6-DimethylanilineSolution,100mg/L,1ml