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Ropivacaine

Product Name
Ropivacaine
CAS No.
84057-95-4
Chemical Name
Ropivacaine
Synonyms
Naropin;Naropine;ROPIVACAINE;MesylateBase;S-ROPIVACAINE;ROPACARAINEHCL;Ropivacainebase;Ropivacaine API;ROM. Pp because;Ropivacaine (200 mg)
CBNumber
CB4412687
Molecular Formula
C17H26N2O
Formula Weight
274.4
MOL File
84057-95-4.mol
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Ropivacaine Property

Melting point:
144-146°
alpha 
D25 -82.0° (c = 2 in methanol)
Boiling point:
410.2±45.0 °C(Predicted)
Density 
1.044±0.06 g/cm3(Predicted)
pka
8.16(at 25℃)
InChIKey
ZKMNUMMKYBVTFN-HNNXBMFYSA-N
CAS DataBase Reference
84057-95-4(CAS DataBase Reference)
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Safety

HS Code 
2933399090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2571
Product name
Ropivacaine
Packaging
500MG
Price
$179
Updated
2021/03/22
Sigma-Aldrich
Product number
1605497
Product name
Ropivacaine
Packaging
200mg
Price
$366
Updated
2021/03/22
Alfa Aesar
Product number
H37974
Product name
Ropivacaine
Purity
97%
Packaging
250mg
Price
$51.9
Updated
2021/03/22
Alfa Aesar
Product number
H37974
Product name
Ropivacaine
Purity
97%
Packaging
1g
Price
$134
Updated
2021/03/22
Alfa Aesar
Product number
H37974
Product name
Ropivacaine
Purity
97%
Packaging
5g
Price
$466
Updated
2021/03/22
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Ropivacaine Chemical Properties,Usage,Production

Description

Naropin was launched in 1996 in Australia, Denmark, Finland, the Netherlands and Sweden as a local anesthetic. It can be prepared in a number of ways the most efficient involves a three step sequence beginning with L-pipecolic acid. This compound is the first one in this family to be produced as the pure (S)- enantiomer. The (R)-enantiomer has been shown to have cardiotoxic effects. Thus ropivicaine has less cardiovascular and CNS toxicity than bupivacaine. It is a Na channel blocker that is specific for affecting nerve fibers responsible for transmission of pain (Aδ and C) with no effect on fibers responsible for motor function (Aβ). Clinically, it has distinct advantages over bupivacaine. Its effects are slower in onset, less intense and have a shorter duration. This is a result of extensive metabolism in the liver to the 3-hydroxy isomer by CYPIA2 isoenzyme.

Originator

Astra (Sweden)

Uses

Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly. - See more at: http://www.selleckchem.com/products/ropivacaine-hcl.html#sthash.hTK3J8yF.dpuf

Definition

ChEBI: A piperidinecarboxamide-based amide-type local anaesthetic (amide caine) in which (S)-N-propylpipecolic acid and 2,6-dimethylaniline are combined to form the amide bond.

brand name

Narapin [as hydrochloride] (Astra).

Biological Functions

Ropivacaine (Naropin) is a recently developed longacting amide-linked local anesthetic. Its duration of action is similar to that of bupivacaine, but it is slightly less potent and requires higher concentrations to achieve the same degree of block. Its primary advantage over bupivacaine is its lesser degree of cardiotoxicity.

General Description

The recognized increase in cardiotoxicity of one bupivacaineisomer led to the stereospecific production of ropivacaine asthe single “S” (-) enantiomer. Ropivacaine is the propylanalog of mepivacaine (methyl) and bupivacaine (butyl). ThepKa of the tertiary nitrogen is 8.1, and it displays the same degreeof protein binding as bupivacaine ( 94%). Althoughropivacaine has similar properties as bupivacaine, it displaysless cardiotoxicity. The shortened alkyl chain gives it approximatelyone third of the lipid solubility of bupivacaine.

Clinical Use

Ropivacaine is a long-acting amide-type local anestheticwith inherent vasoconstrictor activities, so it does not requirethe use of additional vasoconstrictors. It is approved forepidural, nerve block, infiltration, and intrathecal anesthesia.

Metabolism

The metabolism of ropivacaine in human is mediated by hepatic CYP1A2 isozymes and, to a minor extent, by CYP3A4. The major metabolite is 3-hydroxyropivacaine, and the minor metabolite is (S)-2′,6′-pipecoloxylidide (a N-dealkylated product).

Ropivacaine Preparation Products And Raw materials

Raw materials

Preparation Products

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Ropivacaine Suppliers

Shandong Mingfeng Pharmaceutical and Technology Co. Ltd
Fax
QQ:1345456643
Email
1345456643@qq.com
Country
China
ProdList
163
Advantage
58
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
42923
Advantage
61
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078,021-50426030
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
10006
Advantage
60
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
1938
Advantage
70
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
Country
China
ProdList
8945
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736-
Email
sales@isomersyn.com
Country
China
ProdList
3443
Advantage
57
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Email
market@ennopharm.com
Country
China
ProdList
4271
Advantage
65
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14457
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9844
Advantage
79
Dalian Meilun Biotech Co., Ltd.
Tel
0411-66864596- ;0411-66864952-
Email
sales@meilune.com;sales@meilune.com
Country
China
ProdList
3573
Advantage
58
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View Lastest Price from Ropivacaine manufacturers

Sinoway Industrial co., ltd.
Product
Ropivacaine 84057-95-4
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
99% up, High Density
Supply Ability
20 tons
Release date
2021-07-15
Dideu Industries Group Limited
Product
Ropivacaine USP/EP/BP 84057-95-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ropivacaine HCl 84057-95-4 84057-95-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

84057-95-4, RopivacaineRelated Search:


  • ROPIVACAINE MESYLATER
  • RopivacaineHcl/MesylateBase
  • ROPACARAINEHCL
  • (S)-N-(2,6-Dimethylphenyl)-1-pKIpyl-2-piperidinecarboxamide
  • Naropin
  • 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, (2S)-
  • Naropine
  • (2S)-1-Propyl-2-(2,6-dimethylphenyl)carbamoylpiperidine
  • (2S)-1-Propyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
  • Ropivacainebase
  • Ropivacaine (200 mg)
  • Ropivacaine API
  • Ropivacaine HCl (base)
  • (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide
  • (S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide
  • (2S)-N-(2,6-dimethylphenyl)-1-propyl-piperidine-2-carboxamide
  • Ropivacaine Free base
  • (2r,2'r,3r,3'r,4r)-2,2'-bis(3,4-dihydroxyphenyl)-5,5',7,7'-tetrahydroxy-3,3',4,4'-tetrahydro-2h,2'h-4,8'-bichromene-3,3'-diyl bis(3,4,5-trihydroxybenzoate)
  • S-ROPIVACAINE
  • ROPIVACAINE
  • n-(2,6-dimethylphenyl)-1-propyl-piperidine-2-carboxamide
  • Ropivacaine HCl 84057-95-4
  • ROPIVACAINE CAS NO:84057-95-4
  • MesylateBase
  • LEA-103 HCl fandachem
  • ROM. Pp because
  • Ropivacaine USP/EP/BP
  • 84057-95-4
  • 98717-15-9
  • C17H26N2O
  • API