Amlexanox
- Product Name
- Amlexanox
- CAS No.
- 68302-57-8
- Chemical Name
- Amlexanox
- Synonyms
- Aphthasol;Solf;Amlexanox RS;2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic Acid;Elics;aa-673;NSC7223;amoxanox;CHX-3673;NSC 7223
- CBNumber
- CB6294838
- Molecular Formula
- C16H14N2O4
- Formula Weight
- 298.29
- MOL File
- 68302-57-8.mol
Amlexanox Property
- Melting point:
- >3000C
- Boiling point:
- 570.0±50.0 °C(Predicted)
- Density
- 1.408±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble10mg/mL at warmed, clear
- pka
- 3.95±0.20(Predicted)
- form
- powder
- color
- white to beige
- Merck
- 14,490
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- CAS DataBase Reference
- 68302-57-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-43
- Safety Statements
- 36/37-37-36
- WGK Germany
- 3
- RTECS
- DJ3102000
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0517
- Product name
- Amlexanox
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $105
- Updated
- 2024/03/01
- Product number
- SML0517
- Product name
- Amlexanox
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $421
- Updated
- 2024/03/01
- Product number
- A2401
- Product name
- Amlexanox
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $58
- Updated
- 2024/03/01
- Product number
- A2401
- Product name
- Amlexanox
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $165
- Updated
- 2024/03/01
- Product number
- 14181
- Product name
- Amlexanox
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $92
- Updated
- 2024/03/01
Amlexanox Chemical Properties,Usage,Production
Description
Amlexanox is an orally-active antiasthmatic agent useful in the treatment of bronchial asthma and allergy-related sinus disorders. The therapeutic effect of amlexanox appears to be attributed to its inhibitory actions on leukohiene D4, PAF and histamine.
Chemical Properties
White Crystalline Solid
Originator
Takeda (Japan)
Uses
Inhibits release of allergic mediators from mast cells. Antiallergic; antiasthmatic
Definition
ChEBI: A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.
Manufacturing Process
A mixture of 2 ml of morpholine, 3 ml of dimethylformamide and 10 ml of water was heated to 60°C and under stirring the equal molecular quantity of 6-isopropyl-4-oxo-4H-1-benzopyran-3-carbonitrile was added for 5 minutes. The mixture was heated at that temperature for one hour and the resultant precipitate was filtered, rained with water recrystallized from acetic acid and washed with chloroform. By the above procedure was obtained 2-amino-6- isopropyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde melting at 206°-208°C. A mixture of 4 ml ethyl cyanoacetate, 50 ml of ethanol, 5 ml of piperidine and the equal molecular quantity of 2-amino-6-isopropyl-4-oxo-4H-1-benzopyran- 3-carboxaldehyde was refluxed for 30 minutes and, after cooling, the crystalline precipitate was filtered and washed with chloroform. By above procedure was obtained ethyl-2-amino-7-isopropyl-1-azaxanthone-3- carboxylate, melting after recrystallization from ethanol at 243°-244°C. A mixture of 10 ml of acetic acid and 10 ml of 55% sulfuric acid the equal molecular quantity and 2-ethyl-amino-7-isopropyl-1-azaxanthone-3- carboxylate was stirred at 130°C for 4 hours and, after water was added, the precipitate was collected by filtration and recrystalllized from dimethylformamide to give the 2-amino-7-(1-methylethyl)-5-oxo-5H- [1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, melting point 300°C.
brand name
Aphthasol (Uluru);Solfa.
Therapeutic Function
Antiulcer (topical)
General Description
Amlexanox is an anti-allergic drug with anti-inflammatory properties.
Biochem/physiol Actions
Amlexanox elevates the amount of nonsense-containing mRNAs in treated cells and helps to generate full-length proteins effectively.
storage
Store at -20°C
References
1) Koch et al. (2013), Obesity: Teaching an old drug new tricks – amlexanox targets inflammation to improve metabolic dysfunction; Nat. Rev. Endocrinol., 9 185 2) Reilly et al. (2013), An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice; Nat. Med., 19 313 3) Nasry et al. (2016), Different modalities for treatment of recurrent aphthous stromatitis. A Randomized clinical trial; J. Clin. Exp. Dent. 8 e517 4) Cheng et al. (2018), Aphthous ulcer drug inhibits prostate tumor metastasis by targeting IKKε/TBK1/NFκB signaling; Theranostics 8 4633
Amlexanox Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Amlexanox manufacturers
- Product
- Amlexanox 68302-57-8
- Price
- US $0.00/KG
- Min. Order
- 100g
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2020-10-29
- Product
- Amlexanox 68302-57-8
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08
- Product
- Amlexanox 68302-57-8
- Price
- US $0.00-0.00/Kg/Bag
- Min. Order
- 100g
- Purity
- 99.0%~101.0%
- Supply Ability
- 700kg/month
- Release date
- 2021-06-11