Ethyl hydrogen malonate

Product Name: Ethyl hydrogen malonate
CAS No.: 1071-46-1
Chemical Name: Ethyl hydrogen malonate
Synonyms: MONOETHYL MALONATE;Monoethyl malonic acid;3-ethoxy-3-oxopropanoate;3-ethoxy-3-oxapropanoic acid;3-ethoxy-3-oxo-propanoic acid;en maL;BROP-001;hydrogen maL;Malonic acid 1-ethyl;Ethyl hydrogen malon
CBNumber: CB6477583
Molecular Formula: C5H8O4
Formula Weight: 132.11
MOL File: 1071-46-1.mol

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Ethyl hydrogen malonate Property

Melting point:: -13°C(lit.)
Boiling point:: 106.5 °C/3 mmHg (lit.)
Density: 1.119 g/mL at 25 °C (lit.)
refractive index: n20/D 1.435(lit.)
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Sparingly)
pka: pK1:3.55 (25°C)
form: Liquid
color: Pale yellow
Water Solubility: Miscible with water, chloroform and other solvents.
BRN: 1758845
InChIKey: HGINADPHJQTSKN-UHFFFAOYSA-N
CAS DataBase Reference: 1071-46-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29171900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 445088
Product name: mono-Ethyl malonate
Packaging: 5g
Price: $58.1
Updated: 2024/03/01

TCI Chemical

Product number: M2700
Product name: Monoethyl Malonate
Purity: >98.0%(T)
Packaging: 5g
Price: $35
Updated: 2024/03/01

TCI Chemical

Product number: M2700
Product name: Monoethyl Malonate
Purity: >98.0%(T)
Packaging: 25g
Price: $105
Updated: 2024/03/01

Alfa Aesar

Product number: 044692
Product name: Ethyl hydrogen malonate, 90+%
Packaging: 5g
Price: $31.65
Updated: 2024/03/01

Alfa Aesar

Product number: 044692
Product name: Ethyl hydrogen malonate, 90+%
Packaging: 25g
Price: $102.65
Updated: 2024/03/01

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Ethyl hydrogen malonate Chemical Properties,Usage,Production

Chemical Properties

Yellow liquid

Uses

Ethyl hydrogen malonate is used as a reactant for the preparation of tetramic acids through Dieckmann ring closure and organocatalytic decarboxylative Doebner-Knoevenagel reactions. It is involved in the acylation reactions and Knoevenagel condensation with aldehydes. It is also used in the preparation of gamma-lactones from olefins by intermolecular carbolactonization in presence of Mn(III) acetate as a catalyst.

Uses

Ethyl Hydrogen Malonate has been shown to impair brain mitochondrial succinate and malate transport. It is also found in the extract of Hericum erinaceus mushroom which shows antitumor effects in tumo r-bearing mice.

Definition

ChEBI: Monoethyl malonic acid is a dicarboxylic acid.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 4, p. 417, 1963
Tetrahedron Letters, 26, p. 1411, 1985 DOI: 10.1016/S0040-4039(00)99058-0

Ethyl hydrogen malonate Preparation Products And Raw materials

Raw materials

Preparation Products

RARECHEM AL BI 0736 6-BENZYL-2-THIOURACIL Amlexanox 4-Hydroxy-3,5-dimethoxycinnamic acid

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Ethyl hydrogen malonate Suppliers

Americas 1 Belgium 2 Canada 1 China 261 Europe 1 Germany 5 India 21 Japan 3 Mexico 1 Slovakia 1 South Korea 1 Switzerland 1 United Kingdom 11 United States 38 Global 348

Cool Pharm, Ltd

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Country: China
ProdList: 12346
Advantage: 58

Tianjin Ji Ping Jia Chemical Co., Ltd.

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Email: jpjchem@163.com
Country: China
ProdList: 479
Advantage: 62

J & K SCIENTIFIC LTD.

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Country: China
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PharmaBlock Sciences (Nanjing),Inc.

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Country: China
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Advantage: 55

Meryer (Shanghai) Chemical Technology Co., Ltd.

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Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
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Advantage: 84

TCI (Shanghai) Development Co., Ltd.

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ShangHai DEMO Chemical Co.,Ltd

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Energy Chemical

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Beijing Ouhe Technology Co., Ltd

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ProdList: 12390
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View Lastest Price from Ethyl hydrogen malonate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Ethyl hydrogen malonate 1071-46-1
Price: US $0.10/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10
Release date: 2024-07-07

Hebei Mingeng Biotechnology Co., Ltd

Product: Monoethyl malonic acid 1071-46-1
Price: US $300.00/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 500kg/month
Release date: 2022-05-05

Henan Aochuang Chemical Co.,Ltd.

Product: Ethyl hydrogen malonate 1071-46-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

1071-46-1, Ethyl hydrogen malonateRelated Search:

Diethyl ethylmalonate 2-Ethoxyethanol Ethanol Ethylparaben Hydrogen Ethyl potassium malonate Ethyl Succinyl Chloride Diethyl malonate Dimethyl malonate Diethyl chloromalonate Potassium 3-methoxy-3-oxopropanoate ISOXADIFEN-ETHYL Trinexapac-ethyl MONO-ETHYL SUCCINATE Ethyl acetate 2-AMINODIETHYLMALONATE Ethyl malonyl chloride Diethyl methylmalonate

ETHYL HYDROGEN MALONATE

MONOETHYL MALONATE

3-ethoxy-3-oxapropanoic acid

Monoethyl malonic acid

3-ethoxy-3-oxo-propanoic acid

Ethyl hydrogen malonate, 90+%

Ethoxycarbonylacetic acid

Malonic acid 1-ethyl

Malonic acid 1-ethyl ester

Malonic acid hydrogen 1-ethyl ester

malonic acid half ethyl ester

3-ethoxy-3-keto-propionic acid

Ethyl hydrogen malon

Monoethyl hydrogen malonate

Propanedioic acid, 1-ethyl ester

BROP-001

Ethyl hydrogen malonate, technical, 90%

3-ethoxy-3-oxopropanoate

en maL

Cabozantinib impurity 59

Monoethyl Malonate &gt

hydrogen maL

Valproic Acid Impurity 34

Ethyl Hydrogen Malanoate(MEM)

ETHYL HYDROGENMALONATE 3-ethoxy-3-oxo-propanoic acid mono-Ethyl malonate

1071-46-1

HO2CCH2CO2CH2CH3

HO2CCH2CO2C2H5

C5H8O4

Organic Building Blocks

Esters

CARBOXYLIC ACID

Building Blocks

C2 to C5

Carbonyl Compounds

Thiophenes ,Thiazolines/Thiazolidines

Small molecule

API intermediates

C2 to C5

Carbonyl Compounds

Esters

bc0001