Ethyl malonyl chloride

Product Name: Ethyl malonyl chloride
CAS No.: 36239-09-5
Chemical Name: Ethyl malonyl chloride
Synonyms: ethyl chlorocarbonylacetate;AURORA KA-3051;ETHYL MALONYL CHLORIDE;Ethyl Maloriyl Chloride;EthylMalonylChloride>Tofacitinib Impurity 153;Ethylmalonylchloride,95%;Ethylmalonoyl dichloride;Ethyl malonyl chloride,EMC;Ethyl malonyl monochloride
CBNumber: CB9260539
Molecular Formula: C5H7ClO3
Formula Weight: 150.56
MOL File: 36239-09-5.mol

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Ethyl malonyl chloride Property

Boiling point:: 79-80 °C25 mm Hg(lit.)
Density: 1.196 g/mL at 20 °C
refractive index: n20/D 1.429(lit.)
Flash point:: 154 °F
storage temp.: 2-8°C
solubility: Chloroform (Soluble), DMSO (Sparingly), Ethyl Acetate (Slightly)
form: Liquid
pka: 9.35±0.46(Predicted)
Specific Gravity: 1.176
color: Clear yellow to brown
Water Solubility: REACTS
Sensitive: Moisture Sensitive
BRN: 636215
Stability:: Hygroscopic, Moisture Sensitive
InChI: 1S/C5H7ClO3/c1-2-9-5(8)3-4(6)7/h2-3H2,1H3
InChIKey: KWFADUNOPOSMIJ-UHFFFAOYSA-N
SMILES: CCOC(=O)CC(Cl)=O
CAS DataBase Reference: 36239-09-5(CAS DataBase Reference)
NIST Chemistry Reference: Ethyl malonyl chloride(36239-09-5)

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Safety

Hazard Codes: C
Risk Statements: 14-34
Safety Statements: 7-26-36/37/39-45-36/39
RIDADR: UN 3265 8/PG 3
WGK Germany: 3
F: 10-21
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: II
HS Code: 29171900
Storage Class: 8A - Combustible corrosive hazardous materials
Hazard Classifications: Skin Corr. 1B

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 163872
Product name: Ethyl malonyl chloride
Purity: technical grade
Packaging: 5g
Price: $100
Updated: 2026/04/30

Sigma-Aldrich

Product number: 163872
Product name: Ethyl malonyl chloride
Purity: technical grade
Packaging: 25g
Price: $441
Updated: 2026/04/30

TCI Chemical

Product number: E0484
Product name: Ethyl Malonyl Chloride
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $39
Updated: 2026/04/30

TCI Chemical

Product number: E0484
Product name: Ethyl Malonyl Chloride
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $138
Updated: 2026/04/30

Usbiological

Product number: 449675
Product name: Ethyl Malonyl Chloride
Packaging: 250mg
Price: $312
Updated: 2021/12/16

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Ethyl malonyl chloride Chemical Properties,Usage,Production

Chemical Properties

clear yellow to brown liquid

Uses

Employed in the synthesis of 3-pyrrolin-2-ones via amidation with propargylamines and subsequent base catalyzed 5-exo-dig cyclization.1

Uses

Ethyl malonyl chloride is used in the syntheses of methanofullerodendimers and 3-pyrrolin-2-ones. It plays a vital role in the preparation of 3,5-disubstituted 1,2,4-oxadiazole derivatives, which are potential peptidomimetic building blocks. It is a versatile acylating agent for propargyl alcohols, hydrazines and amines.

General Description

Ethyl malonyl chloride is a versatile acylating agent for propargyl alcohols, hydrazines and amines.

Synthesis

Method I. Ethyl chloroformylacetate, also known as ethyl 3-chloro-3-oxopropionate, ethyl malonate monochloride, can be obtained by chlorination of 3-ethoxy-3-oxopropionic acid, and the chlorination reagent can be selected from sulfoxide chloride and oxalyl chloride.
To a solution of toluene (226 mL) containing 3-ethoxy-3-oxopropionic acid (14.9 g, 112.8 mmol) was added dichlorosulfoxide (26.6 g, 225.6 mmol). The reaction solution was heated and stirred at 110C for 4 hours and then concentrated under reduced pressure to give ethyl chloroformylacetate as a brown oil.
Method II, ethyl malonate (13.2g,100.0mmol) and N,N-dimethylformamide (0.05mL) were stirred and dissolved in dichloromethane (200mL), cooled to 0C in an ice-water bath, oxalic acid chloride (25.4g,200mmol) was added dropwise, and the mixture was stirred at room temperature for 2h, and concentrated to obtain ethyl chloroformyl acetate (14.5g,97%) as a white oily material.

Ethyl malonyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-Piperadinedione 7-FLUORO-3,4-DIHYDRO-6-NITRO-3-OXOQUINOXALINE-2-CARBOXYLIC ACID 2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one 5,6-DIHYDRO-4-(2-METHYL-2-PHENYLHYDRAZINO)-2-1H-PYRIDINONE

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Ethyl malonyl chloride Suppliers

Americas 1 Austria 1 Belgium 1 China 268 Europe 4 Germany 3 India 13 Japan 3 Slovakia 1 South Korea 1 Switzerland 2 United Kingdom 12 United States 29 Global 339

Shanghai Jin Yi Fine Chemical Co.,LTD

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Shanghai Aoyeah Chemical Technology Co., Ltd.

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Email: sales@aoyeahchem.com
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xiamen hongyi

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J & K SCIENTIFIC LTD.

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Alfa Aesar

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TAIYUAN RHF CO.,LTD.

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TCI (Shanghai) Development Co., Ltd.

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ChangShu Haitian Fine Chemicals Co.,Ltd

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View Lastest Price from Ethyl malonyl chloride manufacturers

Hebei Mingeng Biotechnology Co., Ltd

Product: Ethylmalonoyl dichloride 36239-09-5
Price: US $300.00/KG
Min. Order: 10KG
Purity: 99%
Supply Ability: 500kg/month
Release date: 2022-05-05

Career Henan Chemical Co

Product: Ethyl malonyl chloride 36239-09-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-08-06

Career Henan Chemical Co

Product: Ethyl malonyl chloride 36239-09-5
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-21

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(Chloroformyl)acetic Acid Ethyl Ester Ethyl (Chloroformyl)acetate Ethyl 3-Chloro-3-oxopropionate 3-Chloro-3-oxopropionic Acid Ethyl Ester

E845 Ethyl chloroforMylacetate

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Ethyl malonyl monochloride

Tofacitinib Impurity 153

ethyl chlorocarbonylacetate

3-chloro-3-oxo-propanoicaciethylester

Propanoic acid, 3-chloro-3-oxo-, ethyl ester

MALONIC ACID MONOETHYL ESTER CHLORIDE

AURORA KA-3051

(CHLOROFORMYL)ACETIC ACID ETHYL ESTER

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ETHYL MALONYL CHLORIDE

ETHYL (CHLOROFORMYL)ACETATE

Ethyl 3-chloro-3-oxopropionate, Ethyl (chloroformyl)acetate

ETHYL 3-CHLORO-3-OXOPROPIONATE,TECH

Ethyl Maloriyl Chloride

Ethyl malonyl chloride, pract., 90+%

Ethylmalonylchloride,95%

Ethyl malonyl chloride, tech., 90%

ETHYLMALONYLCHLORIDE,TECHNICAL

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2-(Ethoxycarbonyl)acetyl chloride

EthylMalonylChloride&gt

Ethyl 3-Chloro-3-Oxopropanoate,>95%

3-Chloro-3-oxopropionic Acid Ethyl Ester

Ethylmalonoyl dichloride

36239-09-5

CH3CH2OCOCH2COCl

C5H7O3CI

Organic Building Blocks

Carbonyl Compounds

Building Blocks

Acid Halides

Building Blocks

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks

Pharmaceutical raw material

Pharmaceutical intermdiate

Aliphatics