2,4-Piperadinedione

Product Name: 2,4-Piperadinedione
CAS No.: 50607-30-2
Chemical Name: 2,4-Piperadinedione
Synonyms: Piperidine-2,4-dione;PIPERIDIN-2,4-DIONE;2,4-Piperidinedione;2,4-PIPERADINEDIONE;2,4-Dioxopiperidine;2,4-Diketopiperidine;2,4-PiperadinedioneE;2,4-Piperidinedione>Piperidine-2,4-dione 97%;2,4-Piperidinedione, 95+%
CBNumber: CB3511804
Molecular Formula: C5H7NO2
Formula Weight: 113.11
MOL File: 50607-30-2.mol

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2,4-Piperadinedione Property

Melting point:: 98.0 to 102.0 °C
Boiling point:: 362.1±35.0 °C(Predicted)
Density: 1.184±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
pka: 12.00±0.70(Predicted)
color: White to Orange to Green
InChI: InChI=1S/C5H7NO2/c7-4-1-2-6-5(8)3-4/h1-3H2,(H,6,8)
InChIKey: RDNZDMDLRIQQAX-UHFFFAOYSA-N
SMILES: N1CCC(=O)CC1=O

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38-43
Safety Statements: 26-36/37
RIDADR: UN 3335
WGK Germany: 3
HS Code: 2933790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 759368
Product name: 2,4-Piperidinedione
Purity: 97%
Packaging: 250mg
Price: $26.36
Updated: 2024/03/01

TCI Chemical

Product number: P2296
Product name: 2,4-Piperidinedione
Purity: >98.0%(GC)(T)
Packaging: 200mg
Price: $18
Updated: 2024/03/01

TCI Chemical

Product number: P2296
Product name: 2,4-Piperidinedione
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $59
Updated: 2024/03/01

TRC

Product number: P480020
Product name: 2,4-Piperidinedione
Packaging: 5g
Price: $165
Updated: 2021/12/16

TRC

Product number: P480020
Product name: 2,4-Piperidinedione
Packaging: 2.5g
Price: $120
Updated: 2021/12/16

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2,4-Piperadinedione Chemical Properties,Usage,Production

Description

2,4-Piperidinedione is an important piperidine ring-containing intermediate, and its 2,4-piperidinedione, as a characteristic fragment, is widely used as an intermediate in the synthesis of ibrutinib and paliperidone drugs.

Chemical Properties

White to light yellow solid

Uses

2,4-Piperidinedione is a reactant in the synthesis of 1,4-dihydropyridines as TGFβ/Smad inhibitors.

Preparation

The synthesis of 2,4-Piperidinedione involved dissolving 400 mg (2.34 mmol, 1.00 eq.) of Methyl 2,4-dioxo-piperidine-3-carboxylate in a mixture of acetonitrile (20 mL) and water (0.2 mL). The solution was then heated to approximately 86° C. and maintained at this temperature for around 4 hours. After completion of the reaction, the solvent was removed under vacuum, leaving behind a residue of 2,4-Piperidinedione. This residue was further purified using silica gel column chromatography with a mobile phase consisting of dichloromethane and methanol in a ratio of 100:1. The target product, 2,4-Piperidinedione, was obtained as a white solid, with a yield of 27%, corresponding to 70 mg.

2,4-Piperadinedione Preparation Products And Raw materials

Raw materials

PICRIC ACID Benzyltrimethylammonium hydroxide Sodium Ethanethiol N-phenylsulfanylbenzenesulfenamide Ethyl acrylate Ethyl malonyl chloride

Preparation Products

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2,4-Piperadinedione Suppliers

China 204 Europe 2 Germany 1 India 9 Japan 1 United Kingdom 5 United States 17 Global 239

Ningbo yirui biology science and technology co., ltd

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Tianjin Scaxchem Limited Compnay

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Shanghai Hobor Chemical Co., Ltd

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Accela ChemBio Co.,Ltd.

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J & K SCIENTIFIC LTD.

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Pure Chemistry Scientific Inc.

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Tetranov Biopharm

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ShengXiong Biological Technology Development Co., Ltd.

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Email: alpha9196@gmail.com
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View Lastest Price from 2,4-Piperadinedione manufacturers

Henan Fengda Chemical Co., Ltd

Product: Piperidine-2,4-dione 50607-30-2
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Career Henan Chemical Co

Product: 2,4-Piperadinedione 50607-30-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-08-09

Career Henan Chemical Co

Product: 2,4-PiperadinedioneE 50607-30-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%
Supply Ability: 200KG
Release date: 2018-08-15

50607-30-2, 2,4-PiperadinedioneRelated Search:

DROPERIDOL Haloperidol 2',4'-Dichloroacetophenone 2,2,6,6-Tetramethyl-4-piperidinol Triacetonediamine METHYPRYLON Diphenoxylate 3,3-DIMETHYLGLUTARIMIDE DL-Glutethimide 2,6-Dioxopiperidine-3-ammonium chloride Aminoglutethimide Ethyl 4-(4,4-dimethyl-2,6-dioxopiperidin-1-yl)benzoate 1-benzylpiperidine-3,5-dione 5-ETHYL-2,4-PIPERIDINEDIONE Antineoplaston A10 N-Benzyl-2,6-piperidinedion 6-Phenylazaperhydroine-2,4-dione 3-ETHYL-3-METHYLGLUTARIMIDE

piperidine-2,4-dione, dihydropyridine-4,6-dione, 2,4-dioxopiperidine, 2,4-piperidinedione, piperidin-2,4-dione, 2,4-diketopiperidine, Piperidine-2,4-dione

2,4-PiperadinedioneE

Piperidine-2,4-dione 97%

2,4-PIPERADINEDIONE

2,4-Piperidinedione

Piperidine-2,4-dione

PIPERIDIN-2,4-DIONE

dihydropyridine-4,6-dione

2,4-Dioxopiperidine

2,4-Piperidinedione, 95+%

2,4-Diketopiperidine

2,4-Piperidinedione&gt

2,4-Piperidinedione,Piperidine-2,4-dione

2,4-Piperidinedione (9CI, ACI)

50607-30-2

Pharmaceutical intermediate

Heterocycles series