2,4-Piperadinedione

Product Name: 2,4-Piperadinedione
CAS No.: 50607-30-2
Chemical Name: 2,4-Piperadinedione
Synonyms: Piperidine-2,4-dione;PIPERIDIN-2,4-DIONE;2,4-Piperidinedione;2,4-PIPERADINEDIONE;2,4-Dioxopiperidine;2,4-Diketopiperidine;2,4-PiperadinedioneE;2,4-Piperidinedione>Piperidine-2,4-dione 97%;2,4-Piperidinedione, 95+%
CBNumber: CB3511804
Molecular Formula: C5H7NO2
Formula Weight: 113.11
MOL File: 50607-30-2.mol

More

Less

2,4-Piperadinedione Property

Melting point:: 98.0 to 102.0 °C
Boiling point:: 362.1±35.0 °C(Predicted)
Density: 1.184±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
pka: 12.00±0.70(Predicted)
color: White to Orange to Green
InChI: InChI=1S/C5H7NO2/c7-4-1-2-6-5(8)3-4/h1-3H2,(H,6,8)
InChIKey: RDNZDMDLRIQQAX-UHFFFAOYSA-N
SMILES: N1CCC(=O)CC1=O

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38-43
Safety Statements: 26-36/37
RIDADR: UN 3335
WGK Germany: 3
HS Code: 2933790090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 759368
Product name: 2,4-Piperidinedione
Purity: 97%
Packaging: 250mg
Price: $26.36
Updated: 2024/03/01

TCI Chemical

Product number: P2296
Product name: 2,4-Piperidinedione
Purity: >98.0%(GC)(T)
Packaging: 200mg
Price: $18
Updated: 2024/03/01

TCI Chemical

Product number: P2296
Product name: 2,4-Piperidinedione
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $59
Updated: 2024/03/01

TRC

Product number: P480020
Product name: 2,4-Piperidinedione
Packaging: 5g
Price: $165
Updated: 2021/12/16

TRC

Product number: P480020
Product name: 2,4-Piperidinedione
Packaging: 2.5g
Price: $120
Updated: 2021/12/16

More

Less

2,4-Piperadinedione Chemical Properties,Usage,Production

Description

2,4-Piperidinedione is an important piperidine ring-containing intermediate, and its 2,4-piperidinedione, as a characteristic fragment, is widely used as an intermediate in the synthesis of ibrutinib and paliperidone drugs.

Chemical Properties

White to light yellow solid

Uses

2,4-Piperidinedione is a reactant in the synthesis of 1,4-dihydropyridines as TGFβ/Smad inhibitors.

Preparation

The synthesis of 2,4-Piperidinedione involved dissolving 400 mg (2.34 mmol, 1.00 eq.) of Methyl 2,4-dioxo-piperidine-3-carboxylate in a mixture of acetonitrile (20 mL) and water (0.2 mL). The solution was then heated to approximately 86° C. and maintained at this temperature for around 4 hours. After completion of the reaction, the solvent was removed under vacuum, leaving behind a residue of 2,4-Piperidinedione. This residue was further purified using silica gel column chromatography with a mobile phase consisting of dichloromethane and methanol in a ratio of 100:1. The target product, 2,4-Piperidinedione, was obtained as a white solid, with a yield of 27%, corresponding to 70 mg.

2,4-Piperadinedione Preparation Products And Raw materials

Raw materials

PICRIC ACID Benzyltrimethylammonium hydroxide Sodium Ethanethiol N-phenylsulfanylbenzenesulfenamide Ethyl acrylate Ethyl malonyl chloride

Preparation Products

More

Less

2,4-Piperadinedione Suppliers

China 208 Europe 2 Germany 1 India 9 Japan 1 United Kingdom 5 United States 17 Global 243

Ningbo yirui biology science and technology co., ltd

Tel: 15221000252
Email: 278450236@qq.com
Country: China
ProdList: 337
Advantage: 58

Tianjin Scaxchem Limited Compnay

Tel: 022-022-25327698 18920479040
Email: sales@cosychem.com
Country: China
ProdList: 589
Advantage: 55

Shanghai Hobor Chemical Co., Ltd

Tel: 21-21-61026752 13918007836
Fax: 021-51685238
Email: sales@hoborchem.com
Country: China
ProdList: 346
Advantage: 60

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Email: syeu@accelachem.com
Country: China
ProdList: 11710
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12390
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7905
Advantage: 64

ShengXiong Biological Technology Development Co., Ltd.

Tel: 86-021-64960112 13774219177
Fax: 86-021-64960112
Email: alpha9196@gmail.com
Country: China
ProdList: 52
Advantage: 65

More

Less

View Lastest Price from 2,4-Piperadinedione manufacturers

Henan Fengda Chemical Co., Ltd

Product: Piperidine-2,4-dione 50607-30-2
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Career Henan Chemical Co

Product: 2,4-Piperadinedione 50607-30-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-08-09

Career Henan Chemical Co

Product: 2,4-PiperadinedioneE 50607-30-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%
Supply Ability: 200KG
Release date: 2018-08-15

50607-30-2, 2,4-PiperadinedioneRelated Search:

DROPERIDOL Haloperidol 2',4'-Dichloroacetophenone 2,2,6,6-Tetramethyl-4-piperidinol Triacetonediamine METHYPRYLON Diphenoxylate 3,3-DIMETHYLGLUTARIMIDE DL-Glutethimide 2,6-Dioxopiperidine-3-ammonium chloride Aminoglutethimide Ethyl 4-(4,4-dimethyl-2,6-dioxopiperidin-1-yl)benzoate 1-benzylpiperidine-3,5-dione 5-ETHYL-2,4-PIPERIDINEDIONE Antineoplaston A10 N-Benzyl-2,6-piperidinedion 6-Phenylazaperhydroine-2,4-dione 3-ETHYL-3-METHYLGLUTARIMIDE

piperidine-2,4-dione, dihydropyridine-4,6-dione, 2,4-dioxopiperidine, 2,4-piperidinedione, piperidin-2,4-dione, 2,4-diketopiperidine, Piperidine-2,4-dione

2,4-PiperadinedioneE

Piperidine-2,4-dione 97%

2,4-PIPERADINEDIONE

2,4-Piperidinedione

Piperidine-2,4-dione

PIPERIDIN-2,4-DIONE

dihydropyridine-4,6-dione

2,4-Dioxopiperidine

2,4-Piperidinedione, 95+%

2,4-Diketopiperidine

2,4-Piperidinedione&gt

2,4-Piperidinedione,Piperidine-2,4-dione

2,4-Piperidinedione (9CI, ACI)

50607-30-2

Pharmaceutical intermediate

Heterocycles series