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2,4-Piperadinedione

Product Name
2,4-Piperadinedione
CAS No.
50607-30-2
Chemical Name
2,4-Piperadinedione
Synonyms
Piperidine-2,4-dione;PIPERIDIN-2,4-DIONE;2,4-Piperidinedione;2,4-PIPERADINEDIONE;2,4-Dioxopiperidine;2,4-Diketopiperidine;2,4-PiperadinedioneE;2,4-Piperidinedione>Piperidine-2,4-dione 97%;2,4-Piperidinedione, 95+%
CBNumber
CB3511804
Molecular Formula
C5H7NO2
Formula Weight
113.11
MOL File
50607-30-2.mol
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2,4-Piperadinedione Property

Melting point:
98.0 to 102.0 °C
Boiling point:
362.1±35.0 °C(Predicted)
Density 
1.184±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
pka
12.00±0.70(Predicted)
color 
White to Orange to Green
InChI
InChI=1S/C5H7NO2/c7-4-1-2-6-5(8)3-4/h1-3H2,(H,6,8)
InChIKey
RDNZDMDLRIQQAX-UHFFFAOYSA-N
SMILES
N1CCC(=O)CC1=O
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38-43
Safety Statements 
26-36/37
RIDADR 
UN 3335
WGK Germany 
3
HS Code 
2933790090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
759368
Product name
2,4-Piperidinedione
Purity
97%
Packaging
250mg
Price
$26.36
Updated
2024/03/01
TCI Chemical
Product number
P2296
Product name
2,4-Piperidinedione
Purity
>98.0%(GC)(T)
Packaging
200mg
Price
$18
Updated
2024/03/01
TCI Chemical
Product number
P2296
Product name
2,4-Piperidinedione
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$59
Updated
2024/03/01
TRC
Product number
P480020
Product name
2,4-Piperidinedione
Packaging
5g
Price
$165
Updated
2021/12/16
TRC
Product number
P480020
Product name
2,4-Piperidinedione
Packaging
2.5g
Price
$120
Updated
2021/12/16
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2,4-Piperadinedione Chemical Properties,Usage,Production

Description

2,4-Piperidinedione is an important piperidine ring-containing intermediate, and its 2,4-piperidinedione, as a characteristic fragment, is widely used as an intermediate in the synthesis of ibrutinib and paliperidone drugs.

Chemical Properties

White to light yellow solid

Uses

2,4-Piperidinedione is a reactant in the synthesis of 1,4-dihydropyridines as TGFβ/Smad inhibitors.

Preparation

The synthesis of 2,4-Piperidinedione involved dissolving 400 mg (2.34 mmol, 1.00 eq.) of Methyl 2,4-dioxo-piperidine-3-carboxylate in a mixture of acetonitrile (20 mL) and water (0.2 mL). The solution was then heated to approximately 86° C. and maintained at this temperature for around 4 hours. After completion of the reaction, the solvent was removed under vacuum, leaving behind a residue of 2,4-Piperidinedione. This residue was further purified using silica gel column chromatography with a mobile phase consisting of dichloromethane and methanol in a ratio of 100:1. The target product, 2,4-Piperidinedione, was obtained as a white solid, with a yield of 27%, corresponding to 70 mg.

2,4-Piperadinedione Preparation Products And Raw materials

Raw materials

PICRIC ACID Benzyltrimethylammonium hydroxide Sodium Ethanethiol N-phenylsulfanylbenzenesulfenamide Ethyl acrylate Ethyl malonyl chloride

Preparation Products

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2,4-Piperadinedione Suppliers

China 208 Europe 2 Germany 1 India 9 Japan 1 United Kingdom 5 United States 17 Global 243
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
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View Lastest Price from 2,4-Piperadinedione manufacturers

Henan Fengda Chemical Co., Ltd
Product
Piperidine-2,4-dione 50607-30-2
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30
Career Henan Chemical Co
Product
2,4-Piperadinedione 50607-30-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2018-08-09
Career Henan Chemical Co
Product
2,4-PiperadinedioneE 50607-30-2
Price
US $1.00/KG
Min. Order
1KG
Purity
97%
Supply Ability
200KG
Release date
2018-08-15

50607-30-2, 2,4-PiperadinedioneRelated Search:

DROPERIDOL Haloperidol 2',4'-Dichloroacetophenone 2,2,6,6-Tetramethyl-4-piperidinol Triacetonediamine METHYPRYLON Diphenoxylate 3,3-DIMETHYLGLUTARIMIDE DL-Glutethimide 2,6-Dioxopiperidine-3-ammonium chloride Aminoglutethimide Ethyl 4-(4,4-dimethyl-2,6-dioxopiperidin-1-yl)benzoate 1-benzylpiperidine-3,5-dione 5-ETHYL-2,4-PIPERIDINEDIONE Antineoplaston A10 N-Benzyl-2,6-piperidinedion 6-Phenylazaperhydroine-2,4-dione 3-ETHYL-3-METHYLGLUTARIMIDE

  • piperidine-2,4-dione, dihydropyridine-4,6-dione, 2,4-dioxopiperidine, 2,4-piperidinedione, piperidin-2,4-dione, 2,4-diketopiperidine, Piperidine-2,4-dione
  • 2,4-PiperadinedioneE
  • Piperidine-2,4-dione 97%
  • 2,4-PIPERADINEDIONE
  • 2,4-Piperidinedione
  • Piperidine-2,4-dione
  • PIPERIDIN-2,4-DIONE
  • dihydropyridine-4,6-dione
  • 2,4-Dioxopiperidine
  • 2,4-Piperidinedione, 95+%
  • 2,4-Diketopiperidine
  • 2,4-Piperidinedione&gt
  • 2,4-Piperidinedione,Piperidine-2,4-dione
  • 2,4-Piperidinedione (9CI, ACI)
  • 50607-30-2
  • Pharmaceutical intermediate
  • Heterocycles series