4-Hydroxy-3,5-dimethoxycinnamic acid
- Product Name
- 4-Hydroxy-3,5-dimethoxycinnamic acid
- CAS No.
- 530-59-6
- Chemical Name
- 4-Hydroxy-3,5-dimethoxycinnamic acid
- Synonyms
- SINAPIC ACID;SINAPINIC ACID;3,5-DIMETHOXY-4-HYDROXYCINNAMIC ACID;(E)-3-(4-hydroxy-3,5-diMethoxyphenyl)acrylic acid;NSC 59261;Dimethoxy MS;Synapoic acid;Synapitic Acid;SIMPLEXOLIN(RG);rans-sinapicaci
- CBNumber
- CB8328696
- Molecular Formula
- C11H12O5
- Formula Weight
- 224.21
- MOL File
- 530-59-6.mol
4-Hydroxy-3,5-dimethoxycinnamic acid Property
- Melting point:
- ~202 °C
- Boiling point:
- 285.61°C (rough estimate)
- Density
- 1.1478 (rough estimate)
- refractive index
- 1.4720 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- H2O: slightly soluble
- form
- powder
- pka
- 4.53±0.10(Predicted)
- color
- white
- Odor
- at 100.00?%. odorless
- Water Solubility
- insoluble
- BRN
- 2130006
- Stability:
- Stable. Incompatible with strong oxidizing agents, strong bases. Combustible.
- LogP
- 0.997 (est)
- CAS DataBase Reference
- 530-59-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Cinnamic acid, 4-hydroxy-3,5-dimethoxy-(530-59-6)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29189900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 85429
- Product name
- Sinapic acid
- Purity
- matrix substance for MALDI-MS, ≥99.0% (T)
- Packaging
- 1g
- Price
- $91
- Updated
- 2024/03/01
- Product number
- 49508
- Product name
- Sinapic acid
- Purity
- matrix substance for MALDI-MS, ≥99.5%, Ultra pure
- Packaging
- 10x10mg
- Price
- $332
- Updated
- 2024/03/01
- Product number
- D1765
- Product name
- 3,5-Dimethoxy-4-hydroxycinnamic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $57
- Updated
- 2024/03/01
- Product number
- D1765
- Product name
- 3,5-Dimethoxy-4-hydroxycinnamic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $166
- Updated
- 2024/03/01
- Product number
- A15676
- Product name
- 4-Hydroxy-3,5-dimethoxycinnamic acid, 98%
- Packaging
- 1g
- Price
- $30.65
- Updated
- 2024/03/01
4-Hydroxy-3,5-dimethoxycinnamic acid Chemical Properties,Usage,Production
Chemical Properties
yellow-brown crystalline powder
Uses
4-Hydroxy-3,5-dimethoxycinnamic acid is a commonly used matrix in MALDI mass spectrometry. It is a useful matrix for a wide variety of peptides and proteins. It serves well as a matrix for MALDI due to its ability to absorb laser radiation and to also donate protons (H+) to the analyte of interest.
Uses
Sinapic acid was suitable as phenolic standard for HPLC analysis in determination of Sinapic acid derivatives in Canola extracts. 10 g/L of sinapinic acid with solvent was suitable as matrix for ultraviolet laser desorption mass spectrometric determination of proteins. It was also suitable to use as matrix for MALDI-TOFMS and MALDI-ion mobility-TOFMS to determine phospholipids in tissue.
Definition
ChEBI: A monohydroxycinnamic acid that is cinnamic acid in which the phenyl hydrogens at positions 3, 4, and 5 are replaced by methoxy, hydroxy, and methoxy groups, respectively.
General Description
Sinapic acid is an hydroxycinnamic acid derivative that occurs naturally in Brassicaceae species.
Biochem/physiol Actions
On removal of amino group from phenylalanine, catalysing with enzyme phenylalanine ammonia-lyase forms cinnamic acid. The precursor of hydroxycinnamates is produced after hydroxylation of benzene ring. One of the precursors produced is sinapic acid. Sinapic acid exhibits antimicrobial, antioxidant, anticancer, anti-inflammatory, and anti-anxiety activity. Sinapine (sinapoyl choline) has been acknowledged as an acetylcholinesterase inhibitor, making it therapeutically applicable in treatment of various diseases. 4-Vinylsyringol (a decarboxylation product of sinapic acid) is a potent antimutagenic and antioxidative agent, involved in suppressing the induction of inflammatory cytokines and carcinogenesis. Owing to their anti-oxidative activity, these compounds have been considered to be potentially employed in the pharmaceutical industry, cosmetics and food processing.
Purification Methods
Crystallise it from water. [Beilstein 10 H 508, 10 IV 2104.]
4-Hydroxy-3,5-dimethoxycinnamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Hydroxy-3,5-dimethoxycinnamic acid manufacturers
- Product
- Sinapic acid 530-59-6
- Price
- US $0.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-05-25
- Product
- 4-Hydroxy-3,5-dimethoxycinnamic acid 530-59-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-07-04