[2H7]-Ropivacaine

Product Name: [2H7]-Ropivacaine
CAS No.: 684647-62-9
Chemical Name: [2H7]-Ropivacaine
Synonyms: [2H7]-Ropivacaine;D7-(-)-Ropivacaine;Ziresovir Impurity 4
CBNumber: CB58012077
Molecular Formula: C17H26N2O
Formula Weight: 274.41
MOL File: 684647-62-9.mol

More

Less

[2H7]-Ropivacaine Property

form: Solid
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

[2H7]-Ropivacaine Chemical Properties,Usage,Production

Uses

Ropivacaine-d7 is deuterium labeled Ropivacaine. Ropivacain is a potent?sodium channel?blocker. Ropivacain blocks impulse conduction via reversible inhibition of?sodium ion influx?in nerve fibrese[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane[3]. Ropivacaine is used for the research of neuropathic pain?management[1].

Definition

ChEBI: Ropivacaine is the piperidinecarboxamide obtained by the formal condensation of N-propylpipecolic acid and 2,6-dimethylaniline.

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Dene Simpson, et al. Ropivacaine: a review of its use in regional anaesthesia and acute pain management. Drugs. 2005;65(18):2675-717. DOI:10.2165/00003495-200565180-00013
[3] Li TF, et al. Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain. PLoS One. 2015 Jan 24;10(1):e0117321. DOI:10.1371/journal.pone.0117321
[4] Hye Won Shin, et al. The inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on K2P (two-pore domain potassium) channel TREK-1. J Anesth DOI:10.1007/s00540-013-1661-1
[5] Milan Patel, et al. Ropivacaine Inhibits Pressure-Induced Lung Endothelial Hyperpermeability in Models of Acute Hypertension. Life Sci. 2019 Apr 1;222:22-28. DOI:10.1016/j.lfs.2019.02.053

[2H7]-Ropivacaine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

[2H7]-Ropivacaine Suppliers

China 12 United States 1 Global 13

Manhag Testing Technology Co., Ltd

Tel: 020-3846 2365 19110442770
Email: 458677837@qq.com
Country: China
ProdList: 7775
Advantage: 58

QUALITY CONTROL SOLUTIONS LTD.

Tel: +86-0755-66853366 +86-13670046396
Email: export03@qcsrm.com
Country: China
ProdList: 24342
Advantage: 58

Shanghai Beiwanta Biotechnology Co., Ltd.

Tel: 021-67187366 19901745723
Email: info@bwtlab.com
Country: China
ProdList: 9650
Advantage: 58

guoyungurui

Tel: 18162595016; 18162595016
Email: 3287908757@qq.com
Country: China
ProdList: 10335
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 17301488900
Fax: 025-85560043
Email: judy.xia@synzest.com
Country: China
ProdList: 12582
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29496
Advantage: 58

SHANGHAI ZZBIO CO., LTD.

Tel: 15102117276 19921389125
Email: tech@zzbioco.com
Country: China
ProdList: 12064
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175-877 18933936954
Email: 2853283383@qq.com
Country: China
ProdList: 11421
Advantage: 58

TLC Pharmaceutical Standards Ltd.

Tel: 18012923235; 18012923235
Email: chinasales04@tlcstandards.com.cn
Country: China
ProdList: 7974
Advantage: 58

ShangHai ZskBio CO., LTD

Tel: 021-58056897 15399714481
Email: info@zsklab.com
Country: China
ProdList: 7190
Advantage: 58

684647-62-9, [2H7]-RopivacaineRelated Search:

Amlexanox 2-AMINO-7-ISOPROPYL-5-OXO-5 H-[1]BENZOPYRANO[2,3-B]PYRIDINE-3-CARBONITRILE Ethyl 2-amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylate Ropivacaine 5H-[1]Benzopyrano[2,3-b]pyridine-3-carboxylic acid, 2-amino-7-(1-hydroxy-1-methylethyl)-5-oxo- (±)-Ropivacaine-d7 (propyl-d7) ethyl 2-amino-7-methyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylate 5H-[1]Benzopyrano[2,3-b]pyridine-3-carboxylic acid, 7-acetyl-2-amino-5-oxo-

[2H7]-Ropivacaine

Ziresovir Impurity 4

D7-(-)-Ropivacaine

684647-62-9