Citalopram
- Product Name
- Citalopram
- CAS No.
- 59729-33-8
- Chemical Name
- Citalopram
- Synonyms
- CELEXA;cipram;ZD-211;LU-10-171;Ciprarnil;NITALAPRAM;CITALOPRAM;Nitalapram HBr;Citalopram API;Citalopram base
- CBNumber
- CB5244937
- Molecular Formula
- C20H21FN2O
- Formula Weight
- 324.39
- MOL File
- 59729-33-8.mol
Citalopram Property
- Melting point:
- 156-157 °C
- Boiling point:
- bp0.03 175-181°
- Density
- 1.18±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Methanol (Slightly), Water (Slightly)
- pka
- pKa 9.38(H2O) (Uncertain)
- form
- Solid
- color
- White to Off-White
- CAS DataBase Reference
- 59729-33-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Citalopram(59729-33-8)
Safety
- RIDADR
- 3249
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 59729-33-8(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
H361Suspected of damaging fertility or the unborn child
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P391Collect spillage. Hazardous to the aquatic environment
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C5670
- Product name
- Citalopram, Hydrobromide Salt
- Packaging
- 100mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- INB0000265
- Product name
- CITALOPRAM
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $907.14
- Updated
- 2021/12/16
- Product number
- AS147558
- Product name
- Citalopram
- Purity
- 98%
- Packaging
- 250mg
- Price
- $156
- Updated
- 2021/12/16
- Product number
- 2798B
- Product name
- Citalopram
- Packaging
- 1g
- Price
- $169
- Updated
- 2021/12/16
- Product number
- 2798B
- Product name
- Citalopram
- Packaging
- 100mg
- Price
- $69
- Updated
- 2021/12/16
Citalopram Chemical Properties,Usage,Production
Description
Citalopram is a specific serotonin-uptake inhibitor useful in the treatment of depression. In endogenous depression citalopram was reported to be as effective as amitriptyline and mianserin, while being inferior to clomipramine in both endogenous and non-endogenous depression.
Originator
Lundbeck (Denmark)
Uses
scabicide
Uses
antidepressant monoamine oxidase inhibitor (MAOIs)
Definition
ChEBI: A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.
brand name
Cipramil
Biological Functions
Citalopram (Celexa) has an elimination half-life of 35 hours and is 80% bound to plasma proteins. Of all of the SSRIs it has the least effect on the cytochrome P450 system and has the most favorable profile regarding drug–drug interactions.
General Description
Citalopram (Celexa) is a racemic mixture and is very SERTselective. The N-monodemethylated compound is slightlyless potent but is as selective. The aryl substituents are importantfor activity. The ether function is important andprobably interacts with the protonated amino group to givea suitable shape for SERT binding.
Biological Activity
Highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake (IC 50 values are 1.8, 8800 and 41000 nM respectively). Has negligible activity at a wide range of receptors and is clinically used as an antidepressant. Also available as part of the Serotonin Uptake Inhibitor Tocriset™ .
Clinical Use
SSRI antidepressant:
Depressive illness
Panic disorder
Drug interactions
Potentially hazardous interactions with other drugs
Analgesics: increased risk of bleeding with aspirin
and NSAIDs; risk of CNS toxicity increased with
tramadol.
Anti-arrhythmics: increased risk of ventricular
arrhythmias with amiodarone, disopyramide and
dronedarone - avoid.
Antibacterials: possibly increased risk of ventricular
arrhythmias with IV erythromycin, moxifloxacin,
pentamidine and telithromycin.
Anticoagulants: effect of coumarins possibly
enhanced; possibly increased risk of bleeding with
dabigatran.
Antidepressants: avoid with MAOIs and
moclobemide, increased risk of toxicity; avoid with
St John’s wort; possibly enhanced serotonergic
effects with dapoxetine and duloxetine; can increase
tricyclics antidepressant concentration; increased
agitation and nausea with tryptophan; possible
increased risk of convulsions with vortioxetine.
Antiepileptics: convulsive threshold lowered.
Antihistamines: increased risk of ventricular
arrhythmias with mizolastine - avoid.
Antimalarials: avoid with artemether/lumefantrine
and piperaquine with artenimol; possible increased
risk of ventricular arrhythmias with chloroquine and
quinine.
Antipsychotics: possibly increased clozapine
concentration; increased risk of ventricular
arrhythmias with haloperidol and pimozide - avoid.
Antivirals: concentration possibly increased by
ritonavir.
Beta-blockers: increased risk of ventricular
arrhythmias with sotalol - avoid.
Dopaminergics: avoid with selegiline; increased risk
of CNS toxicity with rasagiline.
5 HT1
agonist: increased risk of CNS toxicity -
avoid; possibly increased risk of serotonergic effects
with naratriptan.
Linezolid: use with care, possibly increased risk of
side effects.
Lithium: increased risk of CNS effects.
Methylthioninium: risk of CNS toxicity - avoid if
possible.
Metabolism
Citalopram is metabolised by demethylation, deamination, and oxidation to active and inactive metabolites. The demethylation of citalopram to one of its active metabolites, demethylcitalopram, involves the cytochrome P450 isoenzymes CYP3A4 and CYP2C19; the metabolism of citalopram is also partly dependent on CYP2D6. Didemethylcitalopram has also been identified as a metabolite of citalopram. It is excreted mainly via the liver (85%) with the remainder via the kidneys. About 12% is excreted in the urine as unchanged drug.
Citalopram Preparation Products And Raw materials
Raw materials
Preparation Products
Citalopram Suppliers
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View Lastest Price from Citalopram manufacturers
- Product
- Citalopram 59729-33-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5,000KG
- Release date
- 2024-05-30
- Product
- Citalopram 59729-33-8
- Price
- US $88.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2023-07-21
- Product
- Citalopram 59729-33-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11