Citalopram

ChemicalBook > CAS DataBase List > Citalopram

Product Name: Citalopram
CAS No.: 59729-33-8
Chemical Name: Citalopram
Synonyms: CELEXA;cipram;ZD-211;LU-10-171;Ciprarnil;NITALAPRAM;CITALOPRAM;Nitalapram HBr;Citalopram API;Citalopram base
CBNumber: CB5244937
Molecular Formula: C20H21FN2O
Formula Weight: 324.39
MOL File: 59729-33-8.mol

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Citalopram Property

Melting point:: 156-157 °C
Boiling point:: bp0.03 175-181°
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Methanol (Slightly), Water (Slightly)
pka: pKa 9.38(H2O) (Uncertain)
form: Solid
color: White to Off-White
CAS DataBase Reference: 59729-33-8(CAS DataBase Reference)
NIST Chemistry Reference: Citalopram(59729-33-8)

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Safety

RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 59729-33-8(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

H361Suspected of damaging fertility or the unborn child

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological

Product number: C5670
Product name: Citalopram, Hydrobromide Salt
Packaging: 100mg
Price: $403
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000265
Product name: CITALOPRAM
Purity: 95.00%
Packaging: 50MG
Price: $907.14
Updated: 2021/12/16

Activate Scientific

Product number: AS147558
Product name: Citalopram
Purity: 98%
Packaging: 250mg
Price: $156
Updated: 2021/12/16

AvaChem

Product number: 2798B
Product name: Citalopram
Packaging: 1g
Price: $169
Updated: 2021/12/16

AvaChem

Product number: 2798B
Product name: Citalopram
Packaging: 100mg
Price: $69
Updated: 2021/12/16

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Citalopram Chemical Properties,Usage,Production

Description

Citalopram is a specific serotonin-uptake inhibitor useful in the treatment of depression. In endogenous depression citalopram was reported to be as effective as amitriptyline and mianserin, while being inferior to clomipramine in both endogenous and non-endogenous depression.

Originator

Lundbeck (Denmark)

Uses

scabicide

Uses

antidepressant monoamine oxidase inhibitor (MAOIs)

Definition

ChEBI: A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.

brand name

Cipramil

Biological Functions

Citalopram (Celexa) has an elimination half-life of 35 hours and is 80% bound to plasma proteins. Of all of the SSRIs it has the least effect on the cytochrome P450 system and has the most favorable profile regarding drug–drug interactions.

General Description

Citalopram (Celexa) is a racemic mixture and is very SERTselective. The N-monodemethylated compound is slightlyless potent but is as selective. The aryl substituents are importantfor activity. The ether function is important andprobably interacts with the protonated amino group to givea suitable shape for SERT binding.

Biological Activity

Highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake (IC 50 values are 1.8, 8800 and 41000 nM respectively). Has negligible activity at a wide range of receptors and is clinically used as an antidepressant. Also available as part of the Serotonin Uptake Inhibitor Tocriset™ .

Clinical Use

SSRI antidepressant:
Depressive illness

Panic disorder

Drug interactions

Potentially hazardous interactions with other drugs
Analgesics: increased risk of bleeding with aspirin and NSAIDs; risk of CNS toxicity increased with tramadol.
Anti-arrhythmics: increased risk of ventricular arrhythmias with amiodarone, disopyramide and dronedarone - avoid.
Antibacterials: possibly increased risk of ventricular arrhythmias with IV erythromycin, moxifloxacin, pentamidine and telithromycin.
Anticoagulants: effect of coumarins possibly enhanced; possibly increased risk of bleeding with dabigatran.
Antidepressants: avoid with MAOIs and moclobemide, increased risk of toxicity; avoid with St John’s wort; possibly enhanced serotonergic effects with dapoxetine and duloxetine; can increase tricyclics antidepressant concentration; increased agitation and nausea with tryptophan; possible increased risk of convulsions with vortioxetine.
Antiepileptics: convulsive threshold lowered.
Antihistamines: increased risk of ventricular arrhythmias with mizolastine - avoid.
Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol; possible increased risk of ventricular arrhythmias with chloroquine and quinine.
Antipsychotics: possibly increased clozapine concentration; increased risk of ventricular arrhythmias with haloperidol and pimozide - avoid.
Antivirals: concentration possibly increased by ritonavir.
Beta-blockers: increased risk of ventricular arrhythmias with sotalol - avoid.
Dopaminergics: avoid with selegiline; increased risk of CNS toxicity with rasagiline.
5 HT1 agonist: increased risk of CNS toxicity - avoid; possibly increased risk of serotonergic effects with naratriptan.
Linezolid: use with care, possibly increased risk of side effects.
Lithium: increased risk of CNS effects.
Methylthioninium: risk of CNS toxicity - avoid if possible.

Metabolism

Citalopram is metabolised by demethylation, deamination, and oxidation to active and inactive metabolites. The demethylation of citalopram to one of its active metabolites, demethylcitalopram, involves the cytochrome P450 isoenzymes CYP3A4 and CYP2C19; the metabolism of citalopram is also partly dependent on CYP2D6. Didemethylcitalopram has also been identified as a metabolite of citalopram. It is excreted mainly via the liver (85%) with the remainder via the kidneys. About 12% is excreted in the urine as unchanged drug.

Citalopram Preparation Products And Raw materials

Raw materials

3-Chloro-1-(N,N-dimethyl)propylamine Mineral oil Potassium carbonate Benzofuran

Preparation Products

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View Lastest Price from Citalopram manufacturers

Xiamen Wonderful Bio Technology Co., Ltd.

Product: Citalopram 59729-33-8
Price: US $88.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2023-07-21

Dideu Industries Group Limited

Product: Citalopram 59729-33-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: Citalopram 59729-33-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

59729-33-8, CitalopramRelated Search:

Dihydromyrcenol 4-Dimethylaminobenzoic acid 4-Dimethylaminopyridine Diphenyldimethoxysilane 4-Dimethylaminobenzaldehyde 3-Dimethylaminopropylamine CITALOPRAM HBR,(+/-)-CITALOPRAM HYDROBROMIDE,CITALOPRAM HYDROBROMIDE,Citalopram-D4Br,CITALOPRAM BROMOHYDRATE,Citalopram Hydrobromide Tablets 2-Dimethylaminoethanol citalopram hydrochloride (S)-(+)-CITALOPRAM OXALATE Citalopram Related Compound D Citalopram Related Compound F Citalopram Related Compound B (S)-CITALOPRAM Citalopram Related Compound E Hydrogen (R)-Citalopram Oxalate (S)-(+)-CITALOPRAM-D4 OXALATE

5-ISOBENZOFURANCARBONITRILE, 1,3-DIHYDRO-1-(3-(DIMETHYLAMINO)PROPYL)-1-(4-FLUOROPHENYL)-

1-[3-(DIMETHYLAMINO)PROPYL]-1-(4-FLUOROPHENYL)-1,3-DIHYDRO-5-ISOBENZOFURANCARBONITRILE

LU-10-171

CELEXA

(+/-)-CITALOPRAM

CITALOPRAM

CITALOPRAM, HYDROBROMIDE SALT

NITALAPRAM

1,3-dihydro-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-5-isobenzofuranca

5-isobenzofurancarbonitrile,1,3-dihydro-1-(3-(dimethylamino)propyl)-1-(4-fluor

cipram

CITALOPRAM INTERMEDIATES

N,N-dimethylamino-3-chloropropane HCL

1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3

5-Isobenzofurancarbonitrile, 1-3-(dimethylamino)propyl-1-(4-fluorophenyl)-1,3-dihydro-

CITALOPRAM(SUBJECTTOPATENTFREE)

1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-3H-isobenzofuran-5-carbonitrile

3-Oxo CitalopraM oxalate

1,3-Dihydro-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-5-isobenzofurancarbonitrile

1-(4-Fluorophenyl)-1-[3-(dimethylamino)propyl]-1,3-dihydroisobenzofuran-5-carbonitrile

ZD-211

1-(3-(dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile

(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-

5-Isobenzofurancarbonitrile,1-[3-

Ciprarnil

3-[(1S)-5-cyano-1-(4-fluorophenyl)-3H-isobenzofuran-1-yl]propyl-dimethylammonium

citalopraM 1-[3-(diMethylaMino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran-carbonitrile

EscitalopraM IMpurity A

Citalopram base

Nitalapram HBr

1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile

Citalopram USP/EP/BP

Citalopram hydrobrom

Citalopram D4 OxalateQ: What is Citalopram D4 Oxalate Q: What is the CAS Number of Citalopram D4 Oxalate Q: What is the storage condition of Citalopram D4 Oxalate Q: What are the applications of Citalopram D4 Oxalate

CitalopramQ: What is Citalopram Q: What is the CAS Number of Citalopram Q: What is the storage condition of Citalopram Q: What are the applications of Citalopram

Citalopram API

59729-33-8

59729-38-8

597229-33-8

C20H21FN2O

Isotope

ALUDEX

Serotonin receptor

Cnbio