3-Chloro-1-(N,N-dimethyl)propylamine

Product Name: 3-Chloro-1-(N,N-dimethyl)propylamine
CAS No.: 109-54-6
Chemical Name: 3-Chloro-1-(N,N-dimethyl)propylamine
Synonyms: 3-Chloro-N,N-diMethylpropan-1-aMine;3-Dimethylaminopropyl chloride;CAS:109-54-6;3-Chloro-1-(N;AURORA KA-7644;oro-1-(N,N-dimethyL;3-Chloro-1-(N,N-dime;N-dimethyl)propylamine;Benzydamine Impurity G;Zomitriptan Impurity 07
CBNumber: CB2278089
Molecular Formula: C5H12ClN
Formula Weight: 121.61
MOL File: 109-54-6.mol

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3-Chloro-1-(N,N-dimethyl)propylamine Property

Melting point:: 168℃
Boiling point:: 140 °C
Density: 0.929
refractive index: 1.4320
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Liquid
pka: 9.24±0.28(Predicted)
color: Colorless
Water Solubility: Slightly soluble in water.
Sensitive: Air Sensitive
Stability:: Not stable in Solution
InChI: InChI=1S/C5H12ClN/c1-7(2)5-3-4-6/h3-5H2,1-2H3
InChIKey: NYYRRBOMNHUCLB-UHFFFAOYSA-N
SMILES: C(N(C)C)CCCl
LogP: 1.244 (est)
CAS DataBase Reference: 109-54-6(CAS DataBase Reference)

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Safety

RIDADR: 2735
HazardClass: 8
PackingGroup: Ⅲ

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: C364070
Product name: 3-Chloro-1-(N,N-dimethyl)propylamine
Packaging: 1g
Price: $85
Updated: 2021/12/16

Matrix Scientific

Product number: 072697
Product name: 3-Chloro-1-(N,N-dimethyl)propylamine
Purity: 95+%
Packaging: 1g
Price: $10
Updated: 2021/12/16

Matrix Scientific

Product number: 072697
Product name: 3-Chloro-1-(N,N-dimethyl)propylamine
Purity: 95+%
Packaging: 5g
Price: $14
Updated: 2021/12/16

Matrix Scientific

Product number: 072697
Product name: 3-Chloro-1-(N,N-dimethyl)propylamine
Purity: 95+%
Packaging: 25g
Price: $44
Updated: 2021/12/16

AK Scientific

Product number: X8922
Product name: 3-Chloro-1-(N,N-dimethyl)propylamine,stabilizedwith0.5%oxalicacid
Packaging: 25mL
Price: $61
Updated: 2021/12/16

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3-Chloro-1-(N,N-dimethyl)propylamine Chemical Properties,Usage,Production

Chemical Properties

colorless liquid

Uses

3-Chloro-1-(N,N-dimethyl)propylamine is a genotoxic impurity in drug samples of rizatriptan benzoate. Also, it is the side chain of Chlorpromazine and Amitriptyline.

Synthesis

5407-04-5

109-54-6

General procedure for the synthesis of 3-chloro-1-(N,N-dimethyl)propylamine from N,N-dimethylaminopropyl chloride hydrochloride: flake solid NaOH (42.1 g, 1052.5 mmol, 1.0 eq.) was dissolved in 142.1 g of water, a process which is exothermic, and an aqueous NaOH solution was obtained and then cooled down to 30 °C. In a 500 mL two-neck flask, HCl (104 g, 658 mmol, 1.0 eq.) and the above aqueous NaOH solution were added, the temperature was raised to 45 °C and the reaction was started with continuous stirring for 2 hours. After completion of the reaction, the reaction solution was cooled to room temperature (30 °C). The organic layer was separated and collected to give 74.93 g of wet 3-chloro-1-(N,N-dimethyl)propylamine (CPA). The water content of the product was determined to be 2.755% and the yield was 91.07% (as anhydrous CPA).

References

[1] Patent: CN105294496, 2016, A. Location in patent: Paragraph 0128; 0129; 0130; 0131; 0132
[2] Patent: CN106810523, 2017, A. Location in patent: Paragraph 0021
[3] Patent: WO2007/54105, 2007, A2. Location in patent: Page/Page column 20
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985, p. 2033 - 2038
[5] Patent: WO2009/133052, 2009, A1. Location in patent: Page/Page column 42

3-Chloro-1-(N,N-dimethyl)propylamine Preparation Products And Raw materials

Raw materials

1-Bromopropane Allyl alcohol Dimethylamine Thionyl chloride

Preparation Products

Citalopram

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3-Chloro-1-(N,N-dimethyl)propylamine Suppliers

Austria 1 China 153 Germany 1 India 8 United Kingdom 2 United States 6 USA 1 Global 172

Enlian Biomedical (Chongqing) Co., Ltd.

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Energy Chemical

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Shanghai Hanhong Scientific Co.,Ltd.

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Syntechem Co.,Ltd

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View Lastest Price from 3-Chloro-1-(N,N-dimethyl)propylamine manufacturers

Honest Joy Holdings Limited

Product: (3-chloropropyl)dimethylamine 109-54-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.6%
Supply Ability: 100 tons
Release date: 2022-02-20

Dideu Industries Group Limited

Product: 3-Chloro-1-(N,N-dimethyl)propylamine 109-54-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-18

Career Henan Chemical Co

Product: 3-Chloro-1-(N,N-dimethyl)propylamine 109-54-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: as request
Release date: 2018-12-24

109-54-6, 3-Chloro-1-(N,N-dimethyl)propylamineRelated Search:

N,N-Dimethylformamide Dacthal DIMETHYLTHEXYLSILYL CHLORIDE Sodium chloride CHLORODIMETHYLVINYLSILANE Dimethyl sulfate ETHANE Dimethyl fumarate Choline chloride Polyvinyl chloride tert-Butyldimethylsilyl chloride Isopropylamine Dimethyl ether Thionyl chloride Dimethyl phthalate Ammonium chloride Dimethyl-N-propylamine Potassium chloride

CAS:109-54-6

3-Chloro-1-(N,N-dimethyl)propanamine

dimethylaminopropylchloride

AURORA KA-7644

3-CHLORO-1-(N,N-DIMETHYL)PROPYLAMINE

3-chloropropyl(dimethyl)amine

N-(3-Chloropropyl)-dimethylamine

1-(Dimethylamino)-3-chloropropane

1-Chloro-3-(N,N-dimethylamino)propane

3-Chloro-N,N-dimethyl-1-propanamine

N,N-Dimethyl-3-chloropropane-1-amine

3-Dimethylaminopropyl chloride

3-Chloro-1-(N,N-diMethyl)propylaMine, 95+%

N,N-Dimethyl-3-chloropropylamine

3-Chloro-1-(N,N-dime

3-Chloro-N,N-diMethylpropan-1-aMine

oro-1-(N,N-dimethyL

1-Propanamine, 3-chloro-N,N-dimethyl-

3-Chloro-1-(N,N-dimethyl)propylamine ISO 9001：2015 REACH

N-dimethyl)propylamine

3-Chloro-1-(N

3-Chloro-N,N-dimethylpropan

Rutoside Trihydrate Impurity 15

Benzydamine Impurity G

Zomitriptan Impurity 07

109-54-6

C5H12ClN

Polyamines